Article
Urology & Nephrology
Brandon Renner, Jennifer Laskowski, Felix Poppelaars, Viviana P. Ferreira, Judith Blaine, Alexandra H. Antonioli, Jonathan P. Hannan, James M. Kovacs, Cees Van Kooten, Zhiying You, Matthew C. Pickering, V. Michael Holers, Joshua M. Thurman
Summary: This study demonstrates that the Factor H-related proteins have unique effects on different cell types within the kidney, with FHR E causing glomerular complement dysregulation in vivo. This has important implications for understanding the pathogenesis of glomerular diseases.
KIDNEY INTERNATIONAL
(2022)
Review
Immunology
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira
Summary: The complement system plays a crucial role in both innate and adaptive immunity, with three pathways that can be triggered spontaneously or in response to danger. Pathogens often evade this system by hijacking host complement regulators, such as Factor H, to protect themselves from immune attack. Understanding how pathogens interact with complement regulators like Factor H can provide insights into developing treatment strategies to target pathogen evasion mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag
Summary: Complement dysregulation is a key characteristic of renal diseases like aHUS and C3G, where mutations in proteins like FH and FHRs can lead to complement activation. This study found that 2-O-desulfated heparin derivatives could potentially serve as therapeutics for dysregulated complement diseases by competitively inhibiting FHR1 and FHR5 binding to HSGlx, reducing C3b deposition.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Hector Martin Merinero, Marta Subias, Amaia Pereda, Elena Gomez-Rubio, Lucia Juana Lopez, Constantino Fernandez, Elena Goicoechea de Jorge, Sonsoles Martin-Santamaria, Francisco Javier Canada, Santiago Rodriguez de Cordoba
Summary: Factor H (FH)-related protein 1 (FHR-1) plays a significant role in diseases like atypical hemolytic uremic syndrome (aHUS) by competing with FH in binding to surface-bound C3b to promote complement activation. Abnormally elevated FHR-1/FH activity ratios perpetuate pathological complement dysregulation at complement-activating surfaces.
Review
Immunology
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihaly Jozsi, Erik J. M. Toonen, Diana Pauly
Summary: The human Factor H (FH) family is linked to various diseases, with controversies and discrepancies in its functional roles and quantification, requiring interdisciplinary collaboration to address these challenges.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Hematology
Vahid Afshar-Kharghan
Summary: This study identified the mechanism of excessive complement activation caused by recurrent mutations in FHR-1 in patients with aHUS, providing a better understanding of complement regulation in rare mutations in a rare disease.
Review
Pharmacology & Pharmacy
Christine Skerka, Gabriele Pradel, Luke D. Halder, Peter F. Zipfel, Svante L. H. Zipfel, Olaf Strauss
Summary: FHR-1, a member of the factor H protein family, plays a crucial role in regulating innate immune complement reactions. Recent studies have shown its involvement in various diseases and potential role in inflammation induced by necrosis. This review provides insights into the role of FHR-1 in pathology and identifies it as a potential therapeutic target for inflammatory diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Gautier Breville, Ido Zamberg, Salima Sadallah, Caroline Stephan, Belen Ponte, Jorg D. Seebach
Summary: This study describes the potential pathogenic role of Ig4 autoantibodies in complement-mediated thrombotic microangiopathy in a patient with IgG4-related disease. The patient was successfully treated with plasmapheresis, corticosteroids, and cyclophosphamide, achieving remission. The results suggest a link between genetic predispositions such as CFHR1 and CFHR4 gene deletions and the formation of inhibitory anti-Factor H IgG4 antibodies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Emma Diletta Stea, Christine Skerka, Matteo Accetturo, Francesco Pesce, Thorsten Wiech, Andrea Hartman, Paola Pontrelli, Francesca Conserva, Giuseppe Castellano, Peter F. F. Zipfel, Loreto Gesualdo
Summary: Atypical hemolytic-uremic syndrome (aHUS) is a severe kidney disease caused by genetic or acquired abnormalities. We report a case of aHUS in a patient with rare mutations in the FHR2 gene and found that low FHR2 plasma levels increase the risk of aHUS. Treatments with recombinant FHR2 and eculizumab effectively inhibit cell damage. The patient underwent a kidney transplant and remains disease-free after 5 years.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Quan Li, Yuhan Hu, Xia Fei, Yuanzhao Du, Weiwei Guo, Dianfeng Chu, Xiaobo Wang, Shifeng Wang, Huoying Shi
Summary: Salmonella enterica serovar Typhimurium utilizes strategies to evade host immune defenses, including binding FH to circumvent complement-mediated killing. OmpC was identified as an important FHBP in enhancing survival in serum, but not a critical virulence factor. These findings provide insights into Salmonella pathogenesis and potential therapeutic targets.
VETERINARY MICROBIOLOGY
(2021)
Article
Immunology
Anna L. Tierney, Wajd Mohammed Alali, Thomas Scott, Karen S. Rees-Unwin, Simon J. Clark, Richard D. Unwin
Summary: The SARS-CoV-2 virus continues to cause significant morbidity and mortality worldwide. Dysregulation of the complement cascade, specifically elevations in FHR proteins, may predict disease severity in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Natalia Ruiz -Molina, Juliana Parsons, Eva L. Decker, Ralf Reski
Summary: Human complement is crucial for defense against pathogens and tissue homeostasis. Factor H (FH) and Factor H-related protein 1 (FHR1) are important complement regulators. The structure of synthetic regulators based on FH and FHR1 were modeled using AlphaFold2, and the interactions between C3 fragments, MAC components (C5, C7, and C9), and various regulators were studied using AlphaFold-Multimer (AFM). The findings provide insights into the molecular mechanisms of complement regulation and can guide the development of complement-based therapies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Immunology
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Hochsmann, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt
Summary: The SV-to-LA substitution in the C-terminal regions of FH and FHR-1 diminishes their sialic acid-binding ability, resulting in mild FH deregulation by FHR-1 only on host or host-like surfaces. Conversion of FHR-1 into a sialic acid binder enhances its deregulatory capacity, explaining the pathophysiology of the aHUS-associated FHR-1 SV variant.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiromasa Hirai, Mariko Yamashita, Masanori Matsumoto, Masaki Hayakawa, Kazuya Sakai, Tetsuo Ueda, Nahoko Ogata
Summary: This study compared PNV and AMD by analyzing clinical features and genetic characteristics, finding significant differences in age, presence of unusually large VWF multimers, and subretinal hemorrhages between the PNV and AMD groups.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Wei-Ting Liao, Wei-Ling Chen, You-Lin Tain, Chien-Ning Hsu
Summary: Cardiovascular disease is the leading cause of death among patients with chronic kidney disease, including both adults and children. Hypertension is one of the risk factors for cardiovascular disease. Monitoring blood pressure, cardiac sonography, and assessing arterial stiffness can help detect subclinical cardiovascular disease in pediatric chronic kidney disease patients. Congenital anomalies of the kidney and urinary tract are the main causes of pediatric chronic kidney disease. Complement factor H and related proteins are associated with cardiovascular disease risk in children with chronic kidney disease.
Review
Immunology
Alessandra Zarantonello, Margot Revel, Anne Grunenwald, Lubka T. Roumenina
Summary: This article introduces the central effector molecule of the complement system, C3, and its various forms and fragments. It discusses the role of C3 in diseases and the process of C3 activation. The article also provides a detailed description of the interactions between C3a and opsonins with receptors, as well as the molecular architecture and functions of the receptors.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Cyril Planchais, Alejandra Reyes-Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Summary: This study investigates the molecular interaction between S proteins of SARS-CoV-2 variants and ACE2 receptor, and how this interaction has evolved during the pandemic. It reveals a profound remodeling of the physicochemical characteristics of the interaction during evolution, with Omicron RBD exhibiting unique conformational dynamics and non-covalent forces compared to other variants. The study also explores the impact of these changes on the binding specificity of S proteins and their recognition of unrelated human proteins.
News Item
Oncology
Lubka T. Roumenina, Isabelle Cremer
Summary: A new study shows that intratumoral activation of the complement cascade may be a potential therapy for lung cancer patients with strong EGFR signaling. The expression of CD55 and CD59 triggered by EGFR prevents opsonization of tumor cells, inhibits antitumor immunity, and confers resistance to immune-checkpoint inhibitors.
Article
Oncology
Irati Garmendia, Aditi Varthaman, Solenne Marmier, Mahmud Angrini, Ingrid Matchoua, Aurelie Darbois-Delahousse, Nathalie Josseaume, Pierre-Emmanuel Foy, Lubka T. Roumenina, Naira Naouar, Maxime Meylan, Sophie Siberil, Jules Russick, Pierre-Emmanuel Joubert, Karen Leroy, Diane Damotte, Audrey Mansuet-Lupo, Marie Wislez, Marco Alifano, Laurie Menger, Ignacio Garcia-Verdugo, Jean-Michel Sallenave, Olivier Lantz, Florent Petitprez, Isabelle Cremer
Summary: We found that acute influenza A virus infection has a significant impact on the tumor microenvironment and clinical outcomes of patients with non-small cell lung cancer. Influenza virus can infect both tumor and immune cells, resulting in long-term protumoral effects. Infection with influenza virus alters the transcriptional profile of the tumor microenvironment and is associated with poor survival in patients with lung adenocarcinoma.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Biology
Cyril Planchais, Remi Noe, Marie Gilbert, Maxime Lecerf, Srini V. Kaveri, Sebastien Lacroix-Desmazes, Lubka T. Roumenina, Jordan D. Dimitrov
Summary: Intravascular hemolysis occurs in various pathological conditions, and extracellular hemoglobin and heme play a role in the pathogenesis of hemolytic diseases. This study demonstrates that oxidized hemoglobin can modify the binding characteristics of human immunoglobulins, leading to the binding of unrelated self-proteins. The transfer of heme from methemoglobin to IgG is essential for this acquisition of antibody polyreactivity.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Immunology
Marina de Castro Deus, Idris Boudhabhay, Lubka Roumenina
Meeting Abstract
Immunology
Mikel Rezola Artero, Margot Revel, Lubka Roumenina, Marie-Agnes Dragon-Durey
Meeting Abstract
Immunology
Stephanie Valeaux, Andreas Boettcher, Lubka Roumenina, Veronique Fremaux-Bacchi, Anna Schubart
Article
Immunology
Marie-T. Hopp, Janine Holze, Felicitas Lauber, Laura Holtkamp, Dhruv C. Rathod, Maria A. Miteva, Elisa B. Prestes, Matthias Geyer, Benedicte Manoury, Nicolas S. Merle, Lubka T. Roumenina, Marcelo T. Bozza, Guenther Weindl, Diana Imhof
Summary: Haemolytic disorders lead to excessive release of labile heme, causing proinflammatory and prothrombotic complications. The binding of heme to TLR4 at multiple sites plays a crucial role in the progression of these pathological processes, and TLR4 is essential for heme-mediated cytokine responses in human immune cells.
Meeting Abstract
Transplantation
Anne Grunenwald, Poillerat Victoria, Revel Margot, Voilin Elodie, Robe-Rybkine Tania, Idris Boudhabhay, Steven H. Sacks, Florent Petitprez, Laurent Gilardin, Lubka Roumenina
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Oncology
Margot Revel, Catherine Sautes-Fridman, Wolf-Herman Fridman, Lubka T. Roumenina
Summary: The role of C1q in tumor-associated macrophages is complex and may drive cancer progression, calling for further investigation.
Review
Oncology
Antoine Galmiche, Janusz Rak, Lubka T. Roumenina, Zuzana Saidak
Summary: Tumors often cause a hypercoagulable state that promotes blood clotting complications, including venous thromboembolism. Recent research has shown the connection between coagulome and tumor microenvironment, which is important for studying biomarkers and the interaction between blood vessels and tumor parenchyma. Understanding the mutual influence of the coagulome and tumor microenvironment offers exciting prospects for predicting blood clotting complications and improving cancer treatment effectiveness.
Meeting Abstract
Biochemistry & Molecular Biology
Alexandra Gerogianni, Victoria Poillerat, Jordan Dimitrov, Satheesh Chonat, Kerstin Sandholm, Karin Ekholt, Kristina Nilsson Ekdahl, Tom Eirik Tom Eirik Mollnes, Camilla Mohlin, Lubka Roumenina, Per H. Nilsson
MOLECULAR IMMUNOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Anne Grunerwald, Victoria Poillerat, Idris Boudhabhay, Steven Sacks, Laurent Gilardin, Lubka Roumenina
MOLECULAR IMMUNOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Margot Revel, Marie Daugan, Christine Gaboriaud, Catherine Sautes-Fridman, Wolf Herman Fridman, Lubka Roumenina
MOLECULAR IMMUNOLOGY
(2022)
