The Neonatal Window of Opportunity: Setting the Stage for Life-Long Host-Microbial Interaction and Immune Homeostasis

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life

(2016) Meghan A. Koch et al.   CELL

Composition and stability of intestinal microbiota of healthy children within a Dutch population

(2016) Tim G. J. de Meij et al.   FASEB JOURNAL

Fecal Microbiota Transplantation is Safe and Efficacious for Recurrent or Refractory Clostridium difficile Infection in Patients with Inflammatory Bowel Disease

(2016) Monika Fischer et al.   INFLAMMATORY BOWEL DISEASES

Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer

(2016) Maria G Dominguez-Bello et al.   NATURE MEDICINE

The microbiome in early life: implications for health outcomes

(2016) Sabrina Tamburini et al.   NATURE MEDICINE

Thumb-Sucking, Nail-Biting, and Atopic Sensitization, Asthma, and Hay Fever

(2016) Stephanie J. Lynch et al.   PEDIATRICS

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

(2016) Moran Yassour et al.   Science Translational Medicine

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

(2016) Nadja B. Kristensen et al.   Genome Medicine

Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice

(2016) Aline Dupont et al.   PLoS Pathogens

Protective Effect of Dual-Strain Probiotics in Preterm Infants: A Multi-Center Time Series Analysis

(2016) Luisa A. Denkel et al.   PLoS One

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

(2015) Tiffany C. Scharschmidt et al.   IMMUNITY

Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity

(2015) Paul R. Giacomin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of early neonatal vitamin A supplementation on mortality during infancy in Ghana (Neovita): a randomised, double-blind, placebo-controlled trial

(2015) Karen M Edmond et al.   LANCET

Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency

(2015) M Turfkruyer et al.   Mucosal Immunology

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

(2015) S. Yang et al.   SCIENCE

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis

(2015) Peter Zanvit et al.   Nature Communications

Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period

(2015) Natalia Torow et al.   Nature Communications

Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

(2015) Yael R. Nobel et al.   Nature Communications

Phylogenetic and Metabolic Tracking of Gut Microbiota during Perinatal Development

(2015) Federica Del Chierico et al.   PLoS One

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor

(2014) Celia L Menckeberg et al.   GUT

Global burden of asthma among children

(2014) I. Asher et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

(2014) S. C. Gribar et al.   JOURNAL OF IMMUNOLOGY

Lung microbiota promotes tolerance to allergens in neonates via PD-L1

(2014) Eva S Gollwitzer et al.   NATURE MEDICINE

Cesarean Section and Chronic Immune Disorders

(2014) A. Sevelsted et al.   PEDIATRICS

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

(2014) E. W. Rogier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal bacteria protect against food allergen sensitization

(2014) A. T. Stefka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-invasive analysis of intestinal development in preterm and term infants using RNA-Sequencing

(2014) Jason M. Knight et al.   Scientific Reports

Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella

(2014) Kaiyi Zhang et al.   PLoS Pathogens

Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

(2013) Julia Cahenzli et al.   Cell Host & Microbe

Activation of Islet Autoreactive Naive T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity

(2013) A.-K. Heninger et al.   DIABETES

Biphasic assembly of the murine intestinal microbiota during early development

(2013) Ida Gisela Pantoja-Feliciano et al.   ISME Journal

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

(2013) Anna Cebula et al.   NATURE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human gut microbiota community structures in urban and rural populations in Russia

(2013) Alexander V. Tyakht et al.   Nature Communications

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells

(2012) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The worm returns

(2012) Joel V. Weinstock   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Age-Dependent TLR3 Expression of the Intestinal Epithelium Contributes to Rotavirus Susceptibility

(2012) Johanna Pott et al.   PLoS Pathogens

Prenatal or Early-Life Exposure to Antibiotics and Risk of Childhood Asthma: A Systematic Review

(2011) W. Murk et al.   PEDIATRICS

Distribution of Bacteria in the Epidermal Layers and Hair Follicles of the Human Skin

(2011) B. Lange-Asschenfeldt et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

Growing up on a farm leads to lifelong protection against allergic rhinitis

(2010) J. Eriksson et al.   ALLERGY

Antibiotic Exposure by 6 Months and Asthma and Allergy at 6 Years: Findings in a Cohort of 1,401 US Children

(2010) K. R. Risnes et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine

(2010) Cécilia Chassin et al.   Cell Host & Microbe

Cesarean Delivery Is Associated With Celiac Disease but Not Inflammatory Bowel Disease in Children

(2010) E. Decker et al.   PEDIATRICS

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

(2010) J. E. Mold et al.   SCIENCE

Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens

(2009) K. Aoyama et al.   BLOOD

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbeAcinetobacter lwoffiiF78

(2009) Melanie L. Conrad et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ontogeny of FOXP3+ Regulatory T Cells in the Postnatal Human Small Intestinal and Large Intestinal Lamina Propria

(2009) Jörn-Hendrik Weitkamp et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy

(2008) Michael Pistiner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Developmental switch of intestinal antimicrobial peptide expression

(2008) Sandrine Ménard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Breast milk–mediated transfer of an antigen induces tolerance and protection from allergic asthma

(2008) Valérie Verhasselt et al.   NATURE MEDICINE

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero

(2008) J. E. Mold et al.   SCIENCE

A meta-analysis of the association between Caesarean section and childhood asthma

(2007) S. Thavagnanam et al.   CLINICAL AND EXPERIMENTAL ALLERGY