Review
Immunology
Jia Song, Bi Zhou, Juntao Kan, Guangya Liu, Sheng Zhang, Liang Si, Xianping Zhang, Xue Yang, Junhua Ma, Junrui Cheng, Yongde Yang, Xiaobo Liu
Summary: Perinatal depression, a common mood disorder in pregnant and postpartum women, is associated with changes in hormones and gut microbiota. Nutrition and dietary interventions have been shown to alleviate maternal depression, and probiotics have the potential to modulate the development of perinatal mood disorders through regulating microbiota. However, more human evidence is needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xue-Ying Zhang, Saeid Khakisahneh, Wei Liu, Xinyi Zhang, Weiwei Zhai, Jilong Cheng, John R. Speakman, De-Hua Wang
Summary: Host phylogeny and environment both shape the gut microbiota and host metabolic traits. The assembly of gut microbiota shows strong concordance with host phylogeny and may be influenced by environmental variables, while host metabolic traits seem to be unrelated to phylogeny.
NATIONAL SCIENCE REVIEW
(2023)
Review
Food Science & Technology
Dragan Milenkovic, Frederic Capel, Lydie Combaret, Blandine Comte, Dominique Dardevet, Bertrand Evrard, Christelle Guillet, Laurent-Emmanuel Monfoulet, Alexandre Pinel, Sergio Polakof, Estelle Pujos-Guillot, Didier Remond, Yohann Wittrant, Isabelle Savary-Auzeloux
Summary: Impairment of gut function is a mechanism for the decline in health status in the elderly, involving declines in digestive physiology, metabolism, and immune status. This is associated with changes in the composition and function of the gut microbiota. These alterations can be targeted through nutritional strategies to prevent or delay the occurrence of age-related pathologies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Jingjing Liu, Wei Dong, Jian Zhao, Jing Wu, Jinqiang Xia, Shaofei Xie, Xiaofeng Song
Summary: Through statistical analysis and correlation analysis, the study found that the intestinal flora of mice with colorectal inflammation or colorectal cancer significantly changed compared with healthy mice, with Muribaculaceae and Bacteroidaceae showing strong excluding interactions. The functional changes of the gut microbiota include the up-regulation of the cancers pathway and the down-regulation of the replication and repair pathways.
Article
Microbiology
Yan Li, Qingshan Ma, Guiqin Liu, Zhenwei Zhang, Yandong Zhan, Mingxia Zhu, Changfa Wang
Summary: This study found that the gut microbiota composition in donkeys is altered during pregnancy, especially in the early pregnancy period. Pregnant donkeys had higher microbial richness and lower microbial diversity compared to non-pregnant donkeys. The relative abundances of certain microbial families were significantly different between pregnant and non-pregnant donkeys. Predicted microbial gene functions related to inflammation and apoptosis were enriched in pregnant donkeys. Additionally, pregnant donkeys had higher glucose levels and certain inflammatory markers compared to non-pregnant donkeys.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Chiara Morreale, Cristina Giaroni, Andreina Baj, Laura Folgori, Lucia Barcellini, Amraj Dhami, Massimo Agosti, Ilia Bresesti
Summary: Antibiotic therapy is crucial for treating bacterial infections, but its excessive use, especially during the perinatal period, can have long-lasting negative effects on human health. This includes the spread of antibiotic resistance and disruptions to the gut microbiota, which are detrimental to the health of infants. This review summarizes recent evidence on how antibiotic treatment influences the neonatal gut microbiota and discusses potential microbiome-based approaches for restoring a healthy microbiota in newborns.
Article
Microbiology
Federico Fontana, Giulia Longhi, Chiara Tarracchini, Leonardo Mancabelli, Gabriele Andrea Lugli, Giulia Alessandri, Francesca Turroni, Christian Milani, Marco Ventura
Summary: The correlation between the physical performance of athletes and their gut microbiota has been studied, and it has been found that the gut microbiota plays a crucial role in the health status of athletes. The metabolic activity of the microbial population in the large intestine of athletes may influence their physical performance.
Article
Biochemistry & Molecular Biology
Anastasia A. Zabolotneva, Andrei M. Gaponov, Sergey A. Roumiantsev, Ilya Yu. Vasiliev, Tatiana V. Grigoryeva, Oleg I. Kit, Elena Yu. Zlatnik, Aleksey Yu. Maksimov, Anna S. Goncharova, Inna A. Novikova, Svetlana A. Appolonova, Pavel A. Markin, Aleksandr V. Shestopalov
Summary: Alkylresorcinols (ARs), polyphenolic compounds with diverse biological activities potentially involved in host metabolism regulation, were found to be produced by the human gut microbiota. Alterations in AR content and metabolic activity of the gut microbiota were observed in mice according to diet specifications and olivetol supplementation. The findings suggest that ARs may function as quorum-sensing molecules, influencing gut microbiota composition and host metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Kazuma Yagi, Nobuhiro Asai, Gary B. Huffnagle, Nicholas W. Lukacs, Wendy Fonseca
Summary: Several environmental factors can impact the development of early-life microbiota, which in turn affects the occurrence of respiratory tract infections and diseases. The role of gut and lung microbiota in airway diseases, particularly in the context of respiratory syncytial virus (RSV) infection, is of increasing interest.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Applied
Baojie Zhang, Yadong Zhong, Dejun Dong, Zhitian Zheng, Jielun Hu
Summary: This review focuses on gut microbiota and their utilization of xylan, the second most abundant indigestible carbohydrate found in nature. It summarizes the physico-chemical features of xylan, the xylanases needed for its decomposition, and the microbial degradation of xylan. The implications of xylan on intestinal homeostasis and metabolic response are discussed, with emphasis on specific gut microbes and the complexity of xylan structure, providing insights into the inconsistent results in human studies.
CARBOHYDRATE POLYMERS
(2022)
Review
Endocrinology & Metabolism
Jui Tu, Yangmeng Wang, Lihua Jin, Wendong Huang
Summary: Metabolic surgery, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB), is the most effective approach for treating obesity. The precise mechanisms of how these surgeries work are still unclear, but gut hormones, bile acids and gut microbiota have been identified as potential factors. The long-term goal of metabolic/bariatric surgery research is to develop new pharmacotherapeutic options for obesity and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Veterinary Sciences
Jiali Chen, Fuchang Li, Weiren Yang, Shuzhen Jiang, Yang Li
Summary: The study revealed significant differences in microbial abundances and community structures between sows with different litter sizes and gestation stages, which were associated with changes in plasma biochemical parameters, inflammatory factors, and immunoglobulin. Additionally, there was a significant correlation between litter size and gut microbiota of sows, providing a microbial perspective to improve sow reproductive performance in pig production.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Applied
Jing Zhang, Ping Zhou, Yudi Xu, Feng Ji, Xin Zheng, Huaiyou Wang, Yongqing Xiao, Ying Liu
Summary: This study conducted in vitro metabolism research and found that gut microbiota can influence the metabolism of rhubarb, which may be the reason for the differences in laxative effects between raw pieces of rhubarb and steamed pieces of rhubarb.
Article
Multidisciplinary Sciences
Dongxia Chen, Junnan Guo, Ao Li, Chengjie Sun, Huibin Lin, Hongyu Lin, Chaoyong Yang, Wei Wang, Jinhao Gao
Summary: In this study, a metabolic fluorine labeling (MEFLA)-based strategy using 19F MRI is proposed for monitoring the dynamic gut microbiota. Different microbiota subgroups are labeled in situ using a panel of peptidoglycan-targeting MEFLA probes with 19F atoms of different chemical shifts. Real-time in vivo imaging is then achieved using multiplexed hotspot 19F MRI. The strategy allows for extended visualization and semiquantitative analysis of the metabolic dynamics of gut microbiota located at different intestinal sections.
Article
Biochemistry & Molecular Biology
Xudong Yi, Rui Cai, Weike Shaoyong, Guoyan Wang, Wenyong Yan, Ri Li, Mingkun Chao, Tiantian Zhao, Lu Deng, Gongshe Yang, Weijun Pang
Summary: Gut health is crucial for perinatal and early weaned mammals, and melatonin may play a role in maintaining gut health through its impact on the gut microbiome. However, more research is needed to fully understand the effects of melatonin on the gut microbiota and its role in mediating gut health.
Article
Medicine, General & Internal
Anna Lisa Montemari, Valeria Marzano, Nour Essa, Stefano Levi Mortera, Martina Rossitto, Simone Gardini, Laura Selan, Gianluca Vrenna, Andrea Onetti Muda, Lorenza Putignani, Ersilia Vita Fiscarelli
Summary: Cystic fibrosis (CF) is a common rare disease caused by a mutation in the CFTR gene, leading to mucus accumulation and recurrent respiratory infections. Pseudomonas aeruginosa (PA) is the most detected bacterium in CF patients and is able to adapt and cause chronic infections in the hostile environment of the CF lung. This study compared surface protein expression of antibiotic-resistant strains of PA to antibiotic-sensitive strains and characterized their biofilm production.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Marilena Agosta, Daniela Bencardino, Marta Argentieri, Laura Pansani, Annamaria Sisto, Marta Luisa Ciofi Degli Atti, Carmen D'Amore, Lorenza Putignani, Pietro Bagolan, Barbara Daniela Iacobelli, Andrea Dotta, Ludovica Martini, Luca Di Chiara, Mauro Magnani, Carlo Federico Perno, Francesca Andreoni, Paola Bernaschi
Summary: The spread of carbapenemase-producing Enterobacterales (CPE) is a serious public health threat in pediatric hospitals, especially among newborns who have underdeveloped immune systems and limited treatment options. This study aimed to estimate the prevalence and circulation of CPE in neonatal intensive units of a major pediatric hospital in Italy, and investigate their molecular features. The findings showed that the majority of CPE strains were multidrug-resistant and carried the bla(NDM) gene. There was also a high heterogeneity of CPE strains circulating in neonatal units, with some sharing the same circulating clone.
Letter
Biophysics
Pietro Merli, Michele Massa, Alessandra Russo, Francesca Rea, Federica Del Chierico, Federica Galaverna, Francesca Del Bufalo, Stefania Pane, Mattia Algeri, Erminia Francesca Romeo, Luca Masucci, Paola De Angelis, Lorenza Putignani, Franco Locatelli
BONE MARROW TRANSPLANTATION
(2022)
Article
Health Care Sciences & Services
Cristina Graziani, Lucrezia Laterza, Claudia Talocco, Marco Pizzoferrato, Nicoletta Di Simone, Silvia D'Ippolito, Caterina Ricci, Jacopo Gervasoni, Silvia Persichilli, Federica Del Chierico, Valeria Marzano, Stefano Levi Mortera, Aniello Primiano, Andrea Poscia, Francesca Romana Ponziani, Lorenza Putignani, Andrea Urbani, Valentina Petito, Federica Di Vincenzo, Letizia Masi, Loris Riccardo Lopetuso, Giovanni Cammarota, Daniela Romualdi, Antonio Lanzone, Antonio Gasbarrini, Franco Scaldaferri
Summary: Recurrent cystitis (RC) is a common disease mainly caused by intestinal microbiota, with the alteration in intestinal permeability and reduced diversity of gut microbiota playing a major role in its pathogenesis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Francesca Romana Ponziani, Antonio Nesci, Camilla Caputo, Lucia Salvatore, Anna Picca, Federica Del Chierico, Francesco Paroni Sterbini, Emanuele Marzetti, Angela Di Giorgio, Luca Santoro, Lorenza Putignani, Antonio Gasbarrini, Angelo Santoliquido, Maurizio Pompili
Summary: This study finds a high prevalence of lower extremity arterial disease (LEAD) in patients with primary biliary cholangitis (PBC), and it is associated with inflammatory markers and alterations in the gut-liver axis.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Gianluca Ianiro, Michal Puncochar, Nicolai Karcher, Serena Porcari, Federica Armanini, Francesco Asnicar, Francesco Beghini, Aitor Blanco-Miguez, Fabio Cumbo, Paolo Manghi, Federica Pinto, Luca Masucci, Gianluca Quaranta, Silvia De Giorgi, Giusi Desire Sciume, Stefano Bibbo, Federica Del Chierico, Lorenza Putignani, Maurizio Sanguinetti, Antonio Gasbarrini, Mireia Valles-Colomer, Giovanni Cammarota, Nicola Segata
Summary: Our study on the dynamics of microbiome engraftment after FMT and its association with clinical variables uncovered species-specific patterns and presented machine learning models able to predict donors and optimize microbial engraftment.
Review
Immunology
Antonia Piazzesi, Lorenza Putignani
Summary: This article reviews the impact of helminths and gut microbiota on childhood development and pediatric diseases, and discusses how helminths enact changes in their host through gut microbes. The modifications of gut microbiota induced by helminths are of great importance in overcoming parasitic infections and treating inflammatory diseases. Deepening the understanding of helminth-microbiota interactions may lead to novel and more effective therapeutic strategies for childhood disorders.
PARASITE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stefano Levi Mortera, Valeria Marzano, Pamela Vernocchi, Maria Cristina Matteoli, Valerio Guarrasi, Simone Gardini, Federica Del Chierico, Novella Rapini, Annalisa Deodati, Alessandra Fierabracci, Stefano Cianfarani, Lorenza Putignani
Summary: Recent research has shown a correlation between the composition of the human gut microbiota and the onset of type 1 diabetes. In this study, a comprehensive metaproteomic investigation was conducted on children with type 1 diabetes, revealing potential gut microbiota features related to the severity of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Alessandra Lo Presti, Federica Del Chierico, Annamaria Altomare, Francesca Zorzi, Giovanni Monteleone, Lorenza Putignani, Silvia Angeletti, Michele Cicala, Michele Pier Luca Guarino, Massimo Ciccozzi
Summary: This study investigated the phylogenetic dynamics of P. copri in patients with IBS, IBD, and healthy volunteers. Results showed longer genetic distances between IBD and healthy volunteers, as well as between IBD and IBS, indicating higher genetic variability in P. copri sequences within IBD. Different strains of P. copri were found in IBS patients, and a correlation between isolates and disease grading was observed. Understanding the phylogenetic characteristics of P. copri is important for better understanding the interactions between microbiota and the pathophysiology of IBD and IBS.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Franco Scaldaferri, Antonio Maria D'Onofrio, Rosaria Calia, Federica Di Vincenzo, Gaspare Filippo Ferrajoli, Valentina Petito, Eleonora Maggio, Pia Clara Pafundi, Daniele Napolitano, Letizia Masi, Elisa Schiavoni, Caterina Fanali, Pierluigi Puca, Laura Turchini, Loris Riccardo Lopetuso, Federica Del Chierico, Lorenza Putignani, Antonio Gasbarrini, Giovanni Camardese
Summary: Psychiatric disorders are more common in patients with UC than in the general population. This study found a correlation between active UC, specific taxonomic gut microbiota signatures, and peculiar psychiatric distress, especially anxiety and depression.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Lucrezia Laterza, Lorenza Putignani, Carlo Romano Settanni, Valentina Petito, Simone Varca, Flavio De Maio, Gabriele Macari, Valerio Guarrasi, Elisa Gremese, Barbara Tolusso, Giulia Wlderk, Maria Antonia Pirro, Caterina Fanali, Franco Scaldaferri, Laura Turchini, Valeria Amatucci, Maurizio Sanguinetti, Antonio Gasbarrini
Summary: This study investigated the effectiveness of gut microbiota modulation for enhancing recovery after COVID-19. A pilot interventional study was conducted with twenty recently recovered COVID-19 patients to explore the impact of a mixed probiotic containing Lactobacilli, Bifidobacteria, and Streptococcus thermophilus on gastrointestinal symptoms, inflammation, intestinal barrier integrity, and gut microbiota profile. Various markers and computational algorithms were utilized to evaluate the outcomes before and after 8 weeks of probiotic supplementation. The results showed a significant reduction in inflammatory markers and an increase in Bifidobacteria at T-1, indicating potential anti-inflammatory effects and the influence of probiotics on gut microbiota composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Allergy
Claudia Bracaglia, Giulia Marucci, Federica Del Chierico, Alessandra Russo, Manuela Pardeo, Denise Pires Marafon, Andrea Quagliariello, Ivan Caiello, Francesca Rea, Sarka Fingerhutova, Antonella Insalaco, Giusi Prencipe, Pavla Dolezalova, Fabrizio De Benedetti, Lorenza Putignani
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Federica Del Chierico, Valeria Marzano, Matteo Scanu, Sofia Reddel, Maria Lisa Dentici, Rossella Capolino, Maddalena Di Donato, Iolanda Spasari, Ersilia Vita Fiscarelli, Maria Cristina Digilio, Maria Teresa Abreu, Bruno Dallapiccola, Lorenza Putignani
Summary: Williams-Beuren syndrome (WBS) is a genetic disease characterized by the deletion of a region on chromosome 7q11.23 and is associated with various comorbidities. Gut dysbiosis, characterized by an imbalance in proinflammatory and anti-inflammatory bacteria, is found in WBS patients, and is linked to weight gain, gastrointestinal symptoms, and hypertension. The profiling of gut microbiota could serve as a new tool to aid in the clinical management of WBS patients, potentially improving their quality of life.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Federica Del Chierico, Sabrina Cardile, Valerio Baldelli, Tommaso Alterio, Sofia Reddel, Matteo Bramuzzo, Daniela Knafelz, Sara Lega, Fiammetta Bracci, Giuliano Torre, Giuseppe Maggiore, Lorenza Putignani
Summary: This study reveals the dysbiosis of gut microbiota and mycobiota in pediatric patients with PSC-UC, showing an increase in pro-inflammatory pathobionts and a reduction in anti-inflammatory commensals.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Microbiology
Loris Riccardo Lopetuso, Lucrezia Laterza, Valentina Petito, Silvia Pecere, Gianluca Quaranta, Federica Del Chierico, Pierluigi Puca, Elisa Schiavoni, Daniele Napolitano, Andrea Poscia, Gianluca Ianiro, Daniela Pugliese, Lorenza Putignani, Maurizio Sanguinetti, Alessandro Armuzzi, Luca Masucci, Antonio Gasbarrini, Giovanni Cammarota, Franco Scaldaferri
Summary: This study aimed to evaluate the effectiveness of exercise therapy for patients with cervical spondylosis. The results showed that patients who received exercise therapy had significantly better pain levels, functional recovery, and quality of life compared to those who received traditional treatment.