Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes

(2016) Ellen B. Duffy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophage activation syndrome in children with systemic juvenile idiopathic arthritis and systemic lupus erythematosus

(2016) Selin Aytaç et al.   RHEUMATOLOGY INTERNATIONAL

Reduced Atherosclerosis in apoE-inhibitory Fc RIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages

(2015) H. P. Ng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammasomes and human autoimmunity: A comprehensive review

(2015) Chin-An Yang et al.   JOURNAL OF AUTOIMMUNITY

Delinking CARD9 and IL-17: CARD9 Protects againstCandida tropicalisInfection through a TNF-α–Dependent, IL-17–Independent Mechanism

(2015) Natasha Whibley et al.   JOURNAL OF IMMUNOLOGY

Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis

(2015) Christianna Choulaki et al.   ARTHRITIS RESEARCH & THERAPY

Selective Antibody Intervention of Toll-like Receptor 4 Activation through Fc γ Receptor Tethering

(2014) Limin Shang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Complex/Ig Negatively Regulate TLR4-Triggered Inflammatory Response in Macrophages through Fc RIIb-Dependent PGE2 Production

(2014) Y. Zhang et al.   JOURNAL OF IMMUNOLOGY

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Immune Complexes Inhibit IL-1 Secretion and Inflammasome Activation

(2014) John R. Janczy et al.   JOURNAL OF IMMUNOLOGY

OxLDL-induced IL-1beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation

(2013) Weiwei Liu et al.   INFLAMMATION RESEARCH

Pathogenic Role of Modified LDL Antibodies and Immune Complexes in Atherosclerosis

(2013) Maria F. Lopes-Virella et al.   Journal of Atherosclerosis and Thrombosis

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

(2012) Yugang Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

(2012) Meera R. Krishnan et al.   KIDNEY INTERNATIONAL

B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

(2011) Tin Kyaw et al.   CIRCULATION RESEARCH

Dectin-1 and Dectin-2 in innate immunity against fungi

(2011) S. Saijo et al.   INTERNATIONAL IMMUNOLOGY

Autoimmune regulator (AIRE) contributes to Dectin-1–induced TNF-α production and complexes with caspase recruitment domain–containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1

(2011) Luis A. Pedroza et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

(2010) Jeremy Sokolove et al.   ARTHRITIS AND RHEUMATISM

The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE−/− mice

(2010) Yanice V. Mendez-Fernandez et al.   ATHEROSCLEROSIS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Levels of Oxidized LDL and Advanced Glycation End Products-Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes

(2010) M. F. Lopes-Virella et al.   DIABETES

FcγRIIB Inhibits the Development of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

(2010) Ming Zhao et al.   JOURNAL OF IMMUNOLOGY

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

(2010) T. Kyaw et al.   JOURNAL OF IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

(2009) Matthew J. Robinson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

(2008) Xiaoyan Zhao et al.   ARTHRITIS RESEARCH & THERAPY