Bolstering the Number and Function of HSV-1–Specific CD8+Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease

Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses

(2016) Lichen Jing et al.   JOURNAL OF IMMUNOLOGY

Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44 high CD62L low CD8 + T EM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection

(2016) Ruchi Srivastava et al.   JOURNAL OF VIROLOGY

Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice

(2015) Lbachir BenMohamed et al.   CURRENT EYE RESEARCH

HLA-A02:01–Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8+T Cells from Seropositive Asymptomatic Individuals and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpes

(2015) Ruchi Srivastava et al.   JOURNAL OF IMMUNOLOGY

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

(2015) Lbachir BenMohamed et al.   JOURNAL OF NEUROVIROLOGY

Therapeutic Immunization with a Mixture of Herpes Simplex Virus 1 Glycoprotein D-Derived “Asymptomatic” Human CD8+T-Cell Epitopes Decreases Spontaneous Ocular Shedding in Latently Infected HLA Transgenic Rabbits: Association with Low Frequency of Local PD-1+TIM-3+CD8+Exhausted T Cells

(2015) Arif A. Khan et al.   JOURNAL OF VIROLOGY

Phenotypic and Functional Characterization of Herpes Simplex Virus Glycoprotein B Epitope-Specific Effector and Memory CD8+T Cells from Symptomatic and Asymptomatic Individuals with Ocular Herpes

(2015) Arif A. Khan et al.   JOURNAL OF VIROLOGY

Heterologous immunity between viruses

(2015) Raymond M. Welsh et al.   IMMUNOLOGICAL REVIEWS

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

(2014) Sarah Samandary et al.   HUMAN IMMUNOLOGY

The challenges and opportunities for the development of a T-cell epitope-based herpes simplex vaccine

(2014) Tiffany Kuo et al.   VACCINE

Asymptomatic memory CD8+T cells

(2014) Arif Azam Khan et al.   Human Vaccines & Immunotherapeutics

Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV

(2014) Christopher Chiu et al.   PLoS Pathogens

Innovative Strategies to Identify M. tuberculosis Antigens and Epitopes Using Genome-Wide Analyses

(2014) Annemieke Geluk et al.   Frontiers in Immunology

Broadening the Repertoire of Functional Herpes Simplex Virus Type 1-Specific CD8+ T Cells Reduces Viral Reactivation from Latency in Sensory Ganglia

(2013) A. J. St. Leger et al.   JOURNAL OF IMMUNOLOGY

Asymptomatic HLA-A*02:01-Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes

(2013) X. Dervillez et al.   JOURNAL OF IMMUNOLOGY

Local CD4 and CD8 T-Cell Reactivity to HSV-1 Antigens Documents Broad Viral Protein Expression and Immune Competence in Latently Infected Human Trigeminal Ganglia

(2013) Monique van Velzen et al.   PLoS Pathogens

Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK

(2012) Patrick M. Stuart et al.   Clinical & Developmental Immunology

Future of an ‘asymptomatic’ T-cell epitope-based therapeutic herpes simplex vaccine

(2012) Xavier Dervillez et al.   Future Virology

Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

(2012) Jody M. Webre et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine

(2012) Lichen Jing et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the Genital Tract Mucosa with a Lipopeptide/Recombinant Adenovirus Prime/Boost Vaccine Induces Potent and Long-Lasting CD8 + T Cell Immunity against Herpes: Importance of MyD88

(2012) Xiuli Zhang et al.   JOURNAL OF IMMUNOLOGY

Immunodominant “Asymptomatic” Herpes Simplex Virus 1 and 2 Protein Antigens Identified by Probing Whole-ORFome Microarrays with Serum Antibodies from Seropositive Asymptomatic versus Symptomatic Individuals

(2012) Gargi Dasgupta et al.   JOURNAL OF VIROLOGY

Efficacy Results of a Trial of a Herpes Simplex Vaccine

(2012) Robert B. Belshe et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Herpes Simplex Virus Type 1 Latency-Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells

(2012) Aziz Alami Chentoufi et al.   VIRAL IMMUNOLOGY

Defining the Herpes Simplex Virus-Specific CD8 + T Cell Repertoire in C57BL/6 Mice

(2011) Anthony J. St. Leger et al.   JOURNAL OF IMMUNOLOGY

CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation

(2011) Anthony J. St. Leger et al.   JOURNAL OF NEUROVIROLOGY

Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates

(2011) K. Held et al.   JOURNAL OF VIROLOGY

Of mice and not humans: How reliable are animal models for evaluation of herpes CD8+-T cell-epitopes-based immunotherapeutic vaccine candidates?

(2011) Gargi Dasgupta et al.   VACCINE

Nasolacrimal Duct Closure Modulates Ocular Mucosal and Systemic CD4+ T-Cell Responses Induced following Topical Ocular or Intranasal Immunization

(2010) A. A. Chentoufi et al.   Clinical and Vaccine Immunology

Future viral vectors for the delivery of asymptomatic herpes epitope-based immunotherapeutic vaccines

(2010) Aziz Alami Chentoufi et al.   Future Virology

Diversity in CD8+ T Cell Function and Epitope Breadth Among Persons with Genital Herpes

(2010) Kerry J. Laing et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A Novel HLA (HLA-A*0201) Transgenic Rabbit Model for Preclinical Evaluation of Human CD8 + T Cell Epitope-Based Vaccines against Ocular Herpes

(2010) Aziz A. Chentoufi et al.   JOURNAL OF IMMUNOLOGY

CD8 T Cell Cross-Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections

(2010) M. Cornberg et al.   JOURNAL OF IMMUNOLOGY

New concepts in herpes simplex virus vaccine development: notes from the battlefield

(2009) Gargi Dasgupta et al.   Expert Review of Vaccines

Developing an asymptomatic mucosal herpes vaccine: the present and the future

(2009) Gargi Dasgupta et al.   Future Microbiology

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge

(2009) X Zhang et al.   Mucosal Immunology

An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection

(2008) Katharine Looker   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Asymptomatic Human CD4+ Cytotoxic T-Cell Epitopes Identified from Herpes Simplex Virus Glycoprotein B

(2008) A. A. Chentoufi et al.   JOURNAL OF VIROLOGY

Reduction in Severity of a Herpes Simplex Virus Type 1 Murine Infection by Treatment with a Ribozyme Targeting the UL20 Gene RNA

(2008) J. Liu et al.   JOURNAL OF VIROLOGY

Neonatal Intraperitoneal or Intravenous Injections of Recombinant Adeno-Associated Virus Type 8 Transduce Dorsal Root Ganglia and Lower Motor Neurons

(2007) Kevin D. Foust et al.   HUMAN GENE THERAPY