Innovative Strategies to Identify M. tuberculosis Antigens and Epitopes Using Genome-Wide Analyses

Use of Resuscitation-Promoting Factor Proteins Improves the Sensitivity of Culture-based Tuberculosis Testing in Special Samples

(2014) Wei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

(2013) Michele D Tameris et al.   LANCET

Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library

(2013) David M. Lewinsohn et al.   PLoS One

Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset

(2013) Cecilia S. Lindestam Arlehamn et al.   PLoS Pathogens

New pathways of protective and pathological host defense to mycobacteria

(2012) Tom H.M. Ottenhoff   TRENDS IN MICROBIOLOGY

A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice

(2012) Annemieke Geluk et al.   VACCINE

Vaccines against Tuberculosis: Where Are We and Where Do We Need to Go?

(2012) Tom H. M. Ottenhoff et al.   PLoS Pathogens

Double- and monofunctional CD4+ and CD8+ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

(2011) Susanna Commandeur et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

First in humans: A new molecularly defined vaccine shows excellent safety and strong induction of long-livedMycobacterium tuberculosis-specific Th1-cell like responses

(2011) Tom H. M. Ottenhoff et al.   Human vaccines & immunotherapeutics

The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection

(2011) Philana Ling Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Promiscuous Peptide of 16 kDa Antigen Linked to Pam2Cys Protects Against Mycobacterium tuberculosis by Evoking Enduring Memory T-Cell Response

(2011) Uthaman Gowthaman et al.   JOURNAL OF INFECTIOUS DISEASES

A multistage tuberculosis vaccine that confers efficient protection before and after exposure

(2011) Claus Aagaard et al.   NATURE MEDICINE

Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens

(2011) Stephen T. Reece et al.   VACCINE

Genome-Based In Silico Identification of New Mycobacterium tuberculosis Antigens Activating Polyfunctional CD8+ T Cells in Human Tuberculosis

(2010) S. T. Tang et al.   JOURNAL OF IMMUNOLOGY

Comparative expression analysis of rpf-like genes of Mycobacterium tuberculosis H37Rv under different physiological stress and growth conditions

(2010) R. K. Gupta et al.   MICROBIOLOGY-SGM

Resuscitation-promoting Factors Reveal an Occult Population of Tubercle Bacilli in Sputum

(2009) Galina V. Mukamolova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of Mycobacterium tuberculosis in Three High-Burden Populations in Africa

(2009) G. F. Black et al.   Clinical and Vaccine Immunology

Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection

(2009) D. Goletti et al.   EUROPEAN RESPIRATORY JOURNAL

Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

(2009) Nadia Caccamo et al.   PLoS One

Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection

(2009) Sebastian D. Schuck et al.   PLoS One

Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection

(2008) May Young Lin et al.   BIOLOGICAL CHEMISTRY

Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue

(2008) A.P. Davies et al.   TUBERCULOSIS

Host-Pathogen Interactions in Latent Mycobacterium tuberculosis Infection: Identification of New Targets for Tuberculosis Intervention

(2008) May Lin et al.   Endocrine Metabolic & Immune Disorders-Drug Targets