Structural insights into the mechanisms of CNBD channel function

The intrinsically liganded cyclic nucleotide–binding homology domain promotes KCNH channel activation

(2017) Yaxian Zhao et al.   JOURNAL OF GENERAL PHYSIOLOGY

A new mechanism of voltage-dependent gating exposed by K V 10.1 channels interrupted between voltage sensor and pore

(2017) Adam P. Tomczak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a eukaryotic cyclic-nucleotide-gated channel

(2017) Minghui Li et al.   NATURE

CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel

(2017) Zachary M. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels

(2017) Gucan Dai et al.   eLife

HCN-channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects

(2016) Y Han et al.   MOLECULAR PSYCHIATRY

Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana

(2016) Alexander F. Kintzer et al.   NATURE

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism

(2016) J. R. Whicher et al.   SCIENCE

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels

(2016) Marcel P Goldschen-Ohm et al.   eLife

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

(2015) Hannah A. DeBerg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bimodal regulation of an Elk subfamily K+channel by phosphatidylinositol 4,5-bisphosphate

(2015) Xiaofan Li et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Enigmatic Cytoplasmic Regions of KCNH Channels

(2015) João H. Morais-Cabral et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

(2015) Jiangtao Guo et al.   NATURE

A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels

(2015) Luisa Maria Rosaria Napolitano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Mechanism for the Regulation of HCN Ion Channels by the Accessory Protein TRIP8b

(2015) Hannah A. DeBerg et al.   STRUCTURE

Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains

(2015) Éva Lörinczi et al.   Nature Communications

Proline Scan of the hERG Channel S6 Helix Reveals the Location of the Intracellular Pore Gate

(2014) Samrat Thouta et al.   BIOPHYSICAL JOURNAL

A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP

(2014) Madoka Akimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double electron–electron resonance reveals cAMP-induced conformational change in HCN channels

(2014) Michael C. Puljung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function

(2014) Andrea Saponaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Family of prokaryote cyclic nucleotide-modulated ion channels

(2014) M. Brams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

(2014) Julia Kowal et al.   Nature Communications

Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels

(2013) Elena C. Gianulis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

(2013) Lei Hu et al.   JOURNAL OF GENERAL PHYSIOLOGY

The structural mechanism of KCNH-channel regulation by the eag domain

(2013) Yoni Haitin et al.   NATURE

HCN channels: Function and clinical implications

(2013) E. E. Benarroch   NEUROLOGY

Structure of the C-terminal region of an ERG channel and functional implications

(2013) T. I. Brelidze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adrenergic Regulation of HCN4 Channel Requires Protein Association with β2-Adrenergic Receptor

(2012) Derek Greene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural changes during HCN channel gating defined by high affinity metal bridges

(2012) Daniel C.H. Kwan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

(2012) Peter S. Tan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel

(2012) Maria J. Marques-Carvalho et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the carboxy-terminal region of a KCNH channel

(2012) Tinatin I. Brelidze et al.   NATURE

Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels

(2012) J. R. Bankston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetramerization Dynamics of C-terminal Domain Underlies Isoform-specific cAMP Gating in Hyperpolarization-activated Cyclic Nucleotide-gated Channels

(2011) Marco Lolicato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hERG potassium channel gating is mediated by N- and C-terminal region interactions

(2011) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRIP8b Regulates HCN1 Channel Trafficking and Gating through Two Distinct C-Terminal Interaction Sites

(2011) B. Santoro et al.   JOURNAL OF NEUROSCIENCE

Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels

(2011) Noah G. Shuart et al.   Nature Communications

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

(2010) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore

(2010) M. G. Derebe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

(2010) M. G. Derebe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Absence of Direct Cyclic Nucleotide Modulation of mEAG1 and hERG1 Channels Revealed with Fluorescence and Electrophysiological Methods

(2009) Tinatin I. Brelidze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function

(2009) A. S. Lewis et al.   JOURNAL OF NEUROSCIENCE

Association with the Auxiliary Subunit PEX5R/Trip8b Controls Responsiveness of HCN Channels to cAMP and Adrenergic Stimulation

(2009) Gerd Zolles et al.   NEURON

TRIP8b Splice Variants Form a Family of Auxiliary Subunits that Regulate Gating and Trafficking of HCN Channels in the Brain

(2009) Bina Santoro et al.   NEURON

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

(2009) A. S. Gustina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCN channels: Structure, cellular regulation and physiological function

(2008) C. Wahl-Schott et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

C-terminal Movement during Gating in Cyclic Nucleotide-modulated Channels

(2008) Kimberley B. Craven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel

(2008) G. M. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating at the selectivity filter in cyclic nucleotide-gated channels

(2008) J. E. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA