Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels

The eag domain regulates hERG channel inactivation gating via a direct interaction

(2013) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel

(2012) Maria J. Marques-Carvalho et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the carboxy-terminal region of a KCNH channel

(2012) Tinatin I. Brelidze et al.   NATURE

The S4–S5 Linker Acts as a Signal Integrator for hERG K+ Channel Activation and Deactivation Gating

(2012) Chai Ann Ng et al.   PLoS One

Demonstration of Physical Proximity between the N Terminus and the S4-S5 Linker of the Humanether-à-go-go-related Gene (hERG) Potassium Channel

(2011) Pilar de la Peña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant HumanEther-á-go-go-related Gene Potassium Channels

(2011) Elena C. Gianulis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

hERG potassium channel gating is mediated by N- and C-terminal region interactions

(2011) Ahleah S. Gustina et al.   JOURNAL OF GENERAL PHYSIOLOGY

The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

(2011) Chai Ann Ng et al.   PLoS One

Molecular Determinants of Interactions between the N-Terminal Domain and the Transmembrane Core That Modulate hERG K+ Channel Gating

(2011) Jorge Fernández-Trillo et al.   PLoS One

NMR solution structure of the N-terminal domain of hERG and its interaction with the S4–S5 linker

(2010) Qingxin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain

(2010) Frederick W. Muskett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of intracellular domains in the function of the herg potassium channel

(2009) Moza Al-Owais et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Absence of Direct Cyclic Nucleotide Modulation of mEAG1 and hERG1 Channels Revealed with Fluorescence and Electrophysiological Methods

(2009) Tinatin I. Brelidze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

(2009) A. S. Gustina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic and Kinetic Properties of Amino-Terminal and S4-S5 Loop HERG Channel Mutants under Steady-State Conditions

(2008) Carlos Alonso-Ron et al.   BIOPHYSICAL JOURNAL