Article
Medicine, Research & Experimental
Chenyang Guan, Xian Huang, Jinnan Yue, Hongrui Xiang, Samina Shaheen, Zhenyan Jiang, Yuexiao Tao, Jun Tu, Zhenshan Liu, Yufeng Yao, Wen Yang, Zhaoyuan Hou, Junling Liu, Xiao-Dong Yang, Qiang Zou, Bing Su, Zhiduo Liu, Jun Ni, Jinke Cheng, Xuefeng Wu
Summary: The study reveals that SIRT3-mediated deacetylation plays a crucial role in NLRC4 activation, aiding in the clearance of Salmonella typhimurium infection.
Article
Biochemistry & Molecular Biology
Xin Chen, Zaikui Zhang, Naishuang Sun, Jinzhou Li, Zemeng Ma, Zebing Rao, Xiaomeng Sun, Qiang Zeng, Yuxuan Wu, Jiahuang Li, Jing Zhang, Yunzi Chen
Summary: Inflammasomes are important cytosolic complexes that defend against bacterial pathogens. This study demonstrates that the vitamin D receptor (VDR) is a critical regulator of NLRC4 inflammasome activation, promoting the association between NAIPs and NLRC4.
Article
Cell Biology
Laura Migliari Branco, Marcelo Pires Amaral, Henning Boekhoff, Ana Beatriz Figueiredo de Lima, Ingrid Sancho Farias, Silvia Lucena Lage, Gustavo Jose Silva Pereira, Bernardo Simoes Franklin, Karina Ramalho Bortoluci
Summary: Recent studies have shown that the NAIP/NLRC4 inflammasome can be activated not only in bacterial infections but also in non-bacterial infections and sterile inflammation. The involvement of cathepsins, known for their role in NLRP3 activation, in the regulation of NAIP/NLRC4-mediated responses to cytosolic flagellin has also been discovered. This study provides new insights into the role of cathepsins in the NAIP/NLRC4 inflammasome activation.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Xianqi Peng, Abdelaziz Ed-Dra, Yan Song, Mohammed Elbediwi, Reshma B. Nambiar, Xiao Zhou, Min Yue
Summary: This study investigated the protective effects and mechanisms of Lacticaseibacillus rhamnosus on the intestinal mucosal barrier of chicks infected with Salmonella. The results showed that L. rhamnosus significantly reduced diarrhea, improved gut immunity, and inhibited intestinal inflammation in infected chicks. Pre-treatment with L. rhamnosus balanced the expression of immune factors, regulated endotoxin and D-lactic acid levels, and enhanced the function of intestinal mucosal epithelial cells. Additionally, L. rhamnosus weakened the adhesion of Salmonella and increased intestinal microbiota diversity in infected chicks.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Pilar Samperio Ventayol, Petra Geiser, Maria Letizia Di Martino, Alexandra Florbrant, Stefan A. Fattinger, Naemi Walder, Eduardo Sima, Feng Shao, Nelson O. Gekara, Magnus Sundbom, Wolf-Dietrich Hardt, Dominic-Luc Webb, Per M. Hellstrom, Jens Eriksson, Mikael E. Sellin
Summary: The study found that infection with Salmonella Typhimurium triggers focal contractions in intestinal epithelial cells, which are initiated by the NAIP/NLRC4 inflammasome and can prevent infected cell death and expulsion, thereby protecting the integrity of the intestinal epithelium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Wanwu Li, Linxing Li, Xiaolin Yan, Pan Wu, Tianli Zhang, Yu Fan, Shuai Ma, Xinyue Wang, Lingyan Jiang
Summary: The utilization of nitrate promotes Salmonella Typhimurium systemic infection and virulence by contributing to cytoplasm acidification and transcription of virulence genes, and this advantage occurs only under low-oxygen conditions and is regulated by Fnr and the NarX-NarL two-component system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Marisa S. Egan, Jenna Zhang, Sunny Shin
Summary: Inflammasomes are intracellular immune complexes that detect disruptions in cellular integrity and promote proinflammatory responses. The NAIP/NLRC4 inflammasome plays a crucial role in mediating host defense during bacterial infection by responding to flagellin and components of the T3SS apparatus. There are notable species-specific and cell type-specific differences in NAIP/NLRC4 inflammasome responses to bacterial pathogens, which may have arisen due to evolutionary pressures.
CURRENT OPINION IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Balamurugan Sundaram, Thirumala-Devi Kanneganti
Summary: Innate immune receptors detect pathogen and damage-associated molecular patterns, triggering an immune or inflammatory response. NLRs are crucial in this process and can form inflammasomes, which activate pyroptosis and release active cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yuanyuan Wang, Chunmei Wu, Jiacong Gao, Xudong Du, Xiangyun Chen, Mei Zhang
Summary: Salmonella enterica serovar Typhimurium triggers reprogramming of host cell metabolism and an inflammatory response during systemic infection, promoting its survival and replication. Additionally, infection by Salmonella may induce M1 and M2 polarization in macrophages, and alter the actin cytoskeleton to facilitate the formation of Salmonella-containing vacuoles.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Medicine, Research & Experimental
Gillian M. Mackie, Alastair Copland, Masumi Takahashi, Yumiko Nakanishi, Isabel Everard, Tamotsu Kato, Hirotsugu Oda, Takashi Kanaya, Hiroshi Ohno, Kendle M. Maslowski
Summary: The study demonstrates that oral treatment with aromatase A-deficient STm is effective in autochthonous intestinal cancer models, imposes metabolic competition on tumors, and directly affects tumor epithelium, impacting tumor stem cells.
Article
Multidisciplinary Sciences
Shouwen Chen, Shuxin Li, Hao Chen, Yuxin Gong, Dahai Yang, Yuanxing Zhang, Qin Liu
Summary: In this study, a pyroptosis signaling cascade mediated by inflammatory caspases sensing cytosolic LPS and gated by GSDM was identified in Cnidarians. Hydra possesses a functional GSDM protein, HyGSDME, which triggers caspase-dependent cytosolic LPS-induced pyroptosis. A proinflammatory caspase, HyCaspA, was found to sense cytosolic LPS through an unknown N-terminal domain and initiate its oligomerization and self-activation. Additionally, HyCaspA cleaves the apoptotic caspase HyCARD2 to initiate HyGSDME-gated pyroptosis. Furthermore, HyGSDME is distributed on the ectodermal layer of Hydra polyps and functions as a canonical immune defense mechanism against surface-invading bacteria. These findings suggest that the pyroptosis signaling cascade mediated by inflammatory caspases sensing cytosolic LPS is conserved from Cnidarians to mammals.
Review
Immunology
Jiexia Wen, Bin Xuan, Yang Liu, Liwei Wang, Li He, Xiangcai Meng, Tao Zhou, Yimin Wang
Summary: NLRC4 inflammasomes are key regulators of the immune response, playing crucial roles in combating various pathogens. Further investigation is needed to fully understand their activation mechanisms and potential roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Dan-Ni Wang, Jin-Jing Ni, Jian-Hui Li, Ya-Qi Gao, Fang-Jing Ni, Zhen-Zhen Zhang, Jing-Yuan Fang, Jie Lu, Yu-Feng Yao
Summary: Increasing evidence indicates that bacteria play a role in promoting tumorigenesis, yet the mechanisms remain poorly understood. This study reveals that Salmonella infection induces changes in the acetylation of host cell proteins, including CDC42. Decreased acetylation of CDC42 impairs its interaction with PAK4, leading to reduced cell apoptosis and enhanced migration and invasion ability. Furthermore, low CDC42 acetylation predicts a poor prognosis in colorectal cancer patients. These findings suggest that bacterial infection promotes tumorigenesis by modulating CDC42 acetylation.
Article
Immunology
Americo Harry Lopez-Yglesias, Chun-Chi Lu, Marvin A. Lai, Ellen K. Quarles, Xiaodan Zhao, Adeline M. Hajjar, Kelly D. Smith
Summary: Salmonella enterica serovar Typhimurium is a major cause of worldwide gastroenteritis and poses a significant threat to vulnerable populations. Our study reveals that NLRC4 inflammasome induced innate immune responses play distinct roles in systemic and mucosal detection of flagellin and non-flagellin molecules during Salmonella infection.
INFECTION AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Wanwu Li, Shuai Ma, Xiaolin Yan, Xinyue Wang, Huiying Li, Lingyan Jiang
Summary: This study found that the yhjC gene plays an important role in Salmonella Typhimurium infection. Its deletion inhibited the replication ability of S. Typhimurium in macrophages and reduced its colonization in mouse systemic organs (liver and spleen), while increasing the survival rate of infected mice. By regulating multiple virulence genes, yhjC promotes the systemic virulence of S. Typhimurium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Summary: Intestinal PPAR alpha signaling modulates fatty acid uptake through regulating FABP1 expression, contributing to NASH progression. Targeting this pathway could be a potential therapeutic strategy for NASH treatment.
Article
Business
Hongdan Zhao, Yuanhua Chen, Weiwei Liu
Summary: This study constructs a theoretical model based on the self-determination theory to explore how socially responsible human resource management (SRHRM) influences employee moral voice through autonomous motivation and considers the moderating role of person-organization value fit. With a two-stage research method and analysis of 260 valid data, the study found that SRHRM promotes employee moral voice and this positive linkage is mediated by autonomous motivation. Furthermore, the findings reveal that person-organization fit moderates the indirect influences of SRHRM on moral voice via autonomous motivation.
JOURNAL OF BUSINESS ETHICS
(2023)
Article
Oncology
Dapeng Li, Changyu Yao, Zhao Ding, Ping Liu, Xue Chen, Weiwei Liu, Fangzheng Yi, Chuanya Jiang, Hongwu Li, Yehai Liu, Jing Wu
Summary: The study reveals that PES1 expression is associated with prognosis and tumour growth in head and neck squamous cell carcinoma. It also plays a role in drug resistance and may serve as a potential cancer marker and therapeutic target for HNSCC.
Article
Infectious Diseases
Min Jiang, Weiqin Chen, Yong Chen, Jia Chen, Yue Zhang, Hongmei Yin, Yi Li, Weiwei Liu
Summary: The study evaluated the analytical performance of three COVID-19 detection assays: Coyote assay, BioGerm assay, and DaAn assay. The results showed high consistency among these assays, providing a reference for COVID-19 diagnosis.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Gastroenterology & Hepatology
Shuai Yang, Ling Qian, Zhixuan Li, Ye Li, Jian Bai, Bo Zheng, Kun Chen, Xinyao Qiu, Guoxiang Cai, Shan Wang, Haiyan Huang, Jianmin Wu, Yanjing Zhu, Qianwen Zhangyang, Lanyun Feng, Tong Wu, Rui Wu, Airong Yang, Kaiting Wang, Ruiru Wang, Yani Zhang, Yan Zhao, Wenwen Wang, Jinxia Bao, Siyun Shen, Ji Hu, Xuan Wu, Tao Zhou, Zhiqiang Meng, Weiwei Liu, Hongyang Wang, Peng Wang, Lei Chen
Summary: This study characterized the immune microenvironment subtypes of liver metastases and identified potential mechanisms using mass cytometry, transcriptomic and whole-exome sequencing. Five distinct immune subtypes were identified, and patients with terminally exhausted or rare T-cell-inflamed characteristics showed worse prognosis. Increased intratumor heterogeneity, somatic mutations in TP53, KRAS, APC, and PIK3CA, and hyperactivated hypoxia signaling contributed to the formation of these aggressive subtypes. SLC2A1 was found to promote immune suppression and escape in liver metastatic lesions through interaction with Spp1 thorn macrophages and regulatory T cells, and also played a role in primary colorectal cancer.
Article
Engineering, Biomedical
Meiyu Bao, Keyi Wang, Jingqiang Li, Yueying Li, Huanhuan Zhu, Meiling Lu, Yue Zhang, Qiangyuan Fan, Lin Han, Kesheng Wang, Dongyan Wang, Yan Gao, Bo Peng, Zunzhen Ming, Weiwei Liu
Summary: A nanomedicine was designed and fabricated to treat inflammatory bowel disease by modulating mucosal immune homeostasis and optimizing intestinal microorganisms. The nanomedicine exhibited anti-inflammatory function, inflammatory targeting property, and positive regulation of gut microflora. This study provides a new approach for the clinical treatment of colitis.
ACTA BIOMATERIALIA
(2023)
Article
Microbiology
Dan-Ni Wang, Jin-Jing Ni, Jian-Hui Li, Ya-Qi Gao, Fang-Jing Ni, Zhen-Zhen Zhang, Jing-Yuan Fang, Jie Lu, Yu-Feng Yao
Summary: Increasing evidence indicates that bacteria play a role in promoting tumorigenesis, yet the mechanisms remain poorly understood. This study reveals that Salmonella infection induces changes in the acetylation of host cell proteins, including CDC42. Decreased acetylation of CDC42 impairs its interaction with PAK4, leading to reduced cell apoptosis and enhanced migration and invasion ability. Furthermore, low CDC42 acetylation predicts a poor prognosis in colorectal cancer patients. These findings suggest that bacterial infection promotes tumorigenesis by modulating CDC42 acetylation.
Article
Genetics & Heredity
Liyan Deng, Wangchang Li, Weiwei Liu, Yanwen Liu, Bingkun Xie, Martien A. M. Groenen, Ole Madsen, Xiaogan Yang, Zhonglin Tang
Summary: This study compared the metabolic and transcriptomic profiles of Duroc and Luchuan pigs' longissimus dorsi muscle. The results showed that Luchuan pigs had lower levels of certain amino acids, organic acids and nucleic acids, bile acids and hormones, while higher levels of glycerophospholipids, fatty acids, oxidized lipids, alcohols, and amines. Transcriptome analysis also revealed upregulation of genes related to key energy metabolic pathways in Luchuan muscle, while downregulation of genes related to fatty acid oxidation and cholesterol synthesis.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Bruce G. Taylor, Elizabeth A. Mumford, Alejandra M. Kaplan, Weiwei Liu
Summary: There is a lack of research on COVID-19 vaccine hesitancy among law enforcement officers, which hinders the development of health messaging for both officers and the communities they serve. This study aimed to address this gap by conducting the first nationally representative survey of officers on COVID-19 vaccine hesitancy. The findings revealed that 40% of officers were hesitant towards the COVID-19 vaccine, with factors such as education, age, experience, health checkups, and agency policies influencing their hesitancy.
Article
Gastroenterology & Hepatology
Quanri Zhang, Weiwei Liu, Katarzyna Bulek, Han Wang, Megan R. McMullen, Xiaoqin Wu, Nicole Welch, Renliang Zhang, Jaividhya Dasarathy, Srinivasan Dasarathy, Laura E. Nagy, Xiaoxia Li
Summary: This study investigated the association between the endogenous Mincle ligand beta-glucosylceramide (beta-GluCer) and the severity of alcohol-associated liver disease (ALD). The results showed that beta-GluCer concentrations were increased in the serum of patients with severe AH and correlated with disease severity. The study also revealed that beta-GluCer activates Mincle-dependent gasdermin D-mediated formation and release of IL-1 beta-containing extracellular vesicles (sEVs), which contribute to hepatocyte cell death and the pathogenesis of ALD.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hailong Shen, Fangzheng Yi, Zhao Ding, Weiwei Liu, Ping Liu, Zixi Wang, Shixian Liu, Yehai Liu, Dapeng Li
Summary: This study investigated the expression and role of SEC11A in head and neck squamous cell carcinoma (HNSCC). The results showed that SEC11A expression was significantly elevated in HNSCC tissues compared to adjacent normal tissues. Functional assays demonstrated that SEC11A knockdown reduced cell proliferation, migration, and invasion in vitro, and inhibited tumor growth in vivo. These findings suggest that SEC11A plays a crucial role in HNSCC proliferation and progression, and may serve as a potential therapeutic target.
Article
Medicine, Research & Experimental
Jianxin Xiao, Xing Chen, Weiwei Liu, Wen Qian, Katarzyna Bulek, Lingzi Hong, William Miller-Little, Xiaoxia Li, Caini Liu
Summary: TRAF4 plays an important role in IL-33-mediated type 2 pulmonary inflammation by regulating the proliferation of ST2+ mTh2 cells and influencing the development of lung inflammation.
Article
Microbiology
Wenting Zhang, Lin Lyu, Zhihiong Xu, Jinjing Ni, Danni Wang, Jie Lu, Yu-Feng Yao
Summary: This study reveals the role of DNA methylation in the response of Salmonella enterica serovar Typhimurium (S. Typhimurium) to oxidative stress. The researchers found that there is no significant association between DNA methylation and transcription level in most genes, but there is a coincidence of level change between transcription and m6A GATC in certain regulatory regions. These findings provide new insights into the epigenetic regulatory mechanisms of gene expression in S. Typhimurium in the host microenvironment.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Ke Li, Xuan Wu, Yuan Li, Ting-Ting Hu, Weifeng Wang, Frank J. Gonzalez, Weiwei Liu
Summary: This study finds that AKAP12 is associated with stem cell characteristics in colorectal cancer stem cells and regulates the development of colorectal cancer. By regulating the expression of AKAP12 gene, colony formation, sphere formation, and stem cell marker expression in colorectal cancer cells can be reduced. AKAP12 may affect the expression of stemness markers through the AKAP12/PKC/STAT3 signaling pathway, making it an important therapeutic target for blocking the development of colorectal cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Microbiology
Wei-Wei Liu, Piaopiao Pan, Ning-Yi Zhou
Summary: This study reveals the potential of ANME in metabolizing aromatic compounds in cold seep environments through CoA activation of the benzene ring. The presence of PCL and BCL genes in ANME genomes and cold seep environments suggests the capability of heterotrophic metabolism of aromatic compounds by ANME.
MICROBIOLOGY SPECTRUM
(2023)
