The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

(2017) Chikako Shimokawa et al.   IMMUNITY

Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

(2017) Fabio R. Melo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes

(2017) Zhenping Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level

(2017) Régis Joulia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In silico design of novel probes for the atypical opioid receptor MRGPRX2

(2017) Katherine Lansu et al.   Nature Chemical Biology

Dnmt3arestrains mast cell inflammatory responses

(2017) Cristina Leoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice

(2016) C. Ustun et al.   HAEMATOLOGICA

Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules

(2016) Hae Woong Choi et al.   IMMUNITY

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3

(2016) Avanti Desai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

(2016) Paul J. Bryce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different activation signals induce distinct mast cell degranulation strategies

(2016) Nicolas Gaudenzio et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

(2016) Anta Ngkelo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial

(2016) Diamant Thaçi et al.   LANCET

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

(2016) Jonathan J Lyons et al.   NATURE GENETICS

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

(2016) Daniel F Dwyer et al.   NATURE IMMUNOLOGY

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation

(2016) Yingli Shang et al.   NATURE IMMUNOLOGY

Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing

(2016) Roy Drissen et al.   NATURE IMMUNOLOGY

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

(2016) Glenn Cruse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils

(2016) O. Malbec et al.   Science Signaling

Noncanonical NF-κB Signaling in Health and Disease

(2016) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice

(2016) Riccardo Sibilano et al.   Nature Communications

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities

(2016) Sara Montagner et al.   Cell Reports

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice

(2016) C. Ustun et al.   HAEMATOLOGICA

Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils

(2016) O. Malbec et al.   Science Signaling

Mast cells and IgE in defense against venoms: Possible “good side” of allergy?

(2016) Stephen J. Galli et al.   ALLERGOLOGY INTERNATIONAL

No Role for Mast Cells in Obesity-Related Metabolic Dysregulation

(2016) Jindřich Chmelař et al.   Frontiers in Immunology

Differences in grass pollen allergen exposure across Australia

(2015) Paul J. Beggs et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH

GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow

(2015) S. Ohmori et al.   BLOOD

Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance

(2015) Dario A. Gutierrez et al.   Cell Metabolism

Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy

(2015) Chun-Yu Chen et al.   IMMUNITY

Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation

(2015) Binh L. Phong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance

(2015) Yapeng Li et al.   JOURNAL OF IMMUNOLOGY

Additional mutations in SRSF2, ASXL1 and/or RUNX1 identify a high-risk group of patients with KIT D816V+ advanced systemic mastocytosis

(2015) M Jawhar et al.   LEUKEMIA

Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme

(2015) Norbert Krug et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical characteristics and risk profile of patients with elevated baseline serum tryptase

(2014) C. Fellinger et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice

(2014) Ahmet Arac et al.   AMERICAN JOURNAL OF PATHOLOGY

Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology

(2014) Louis Tong et al.   BIOSCIENCE REPORTS

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

(2014) E. Motakis et al.   BLOOD

Key regulators control distinct transcriptional programmes in blood progenitor and mast cells

(2014) F. J. Calero-Nieto et al.   EMBO JOURNAL

Siglec-7 is an inhibitory receptor on human mast cells and basophils

(2014) Sa'ar Mizrahi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria

(2014) Daisuke Fujisawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease

(2014) Fabio R. Melo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis

(2014) Albert Dahdah et al.   JOURNAL OF CLINICAL INVESTIGATION

DEAD-box helicase DP103 defines metastatic potential of human breast cancers

(2014) Eun Myoung Shin et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription Factor GATA1 Is Dispensable for Mast Cell Differentiation in Adult Mice

(2014) K. Ohneda et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Editing of Cellular Responses by the High-Affinity Receptor for IgE

(2014) R. Suzuki et al.   SCIENCE

Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis

(2014) Sigrid Narum et al.   BMJ Open

IκB Kinase 2 Is Essential for IgE-Induced Mast Cell De Novo Cytokine Production but Not for Degranulation

(2014) Katrin Peschke et al.   Cell Reports

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

(2014) Tomoaki Ando et al.   Cell Reports

Vesicular Trafficking and Signaling for Cytokine and Chemokine Secretion in Mast Cells

(2014) Ulrich Blank et al.   Frontiers in Immunology

Comprehensive mutational profiling in advanced systemic mastocytosis

(2013) J. Schwaab et al.   BLOOD

Aryl hydrocarbon receptor controls murine mast cell homeostasis

(2013) Y. Zhou et al.   BLOOD

Perivascular Mast Cells Dynamically Probe Cutaneous Blood Vessels to Capture Immunoglobulin E

(2013) Laurence E. Cheng et al.   IMMUNITY

A Truncated Splice-Variant of the FcεRIβ Receptor Subunit Is Critical for Microtubule Formation and Degranulation in Mast Cells

(2013) Glenn Cruse et al.   IMMUNITY

Antagonistic Regulation by the Transcription Factors C/EBPα and MITF Specifies Basophil and Mast Cell Fates

(2013) Xiaopeng Qi et al.   IMMUNITY

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast Cell Fc RI-Induced Early Growth Response 2 Regulates CC Chemokine Ligand 1-Dependent CD4+ T Cell Migration

(2013) Z. Wu et al.   JOURNAL OF IMMUNOLOGY

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

(2013) Yuumi Nakamura et al.   NATURE

Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2–DP1 receptor paracrine axis

(2013) Yoshitaka Taketomi et al.   NATURE IMMUNOLOGY

Chronic adipose tissue inflammation: all immune cells on the stage

(2013) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

Class I PI3K-mediated Akt and ERK signals play a critical role in FcεRI-induced degranulation in mast cells

(2012) Gensuke Takayama et al.   INTERNATIONAL IMMUNOLOGY

Genetic Evidence for Critical Roles of P38α Protein in Regulating Mast Cell Differentiation and Chemotaxis through Distinct Mechanisms

(2012) Ping Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cell Proteoglycans

(2012) Elin Rönnberg et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Transcription Factor Zeb2 Regulates Signaling in Mast Cells

(2012) E. A. Barbu et al.   JOURNAL OF IMMUNOLOGY

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling

(2012) Michael P Seiler et al.   NATURE IMMUNOLOGY

Therapies for allergic inflammation: refining strategies to induce tolerance

(2012) Cezmi A Akdis   NATURE MEDICINE

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

(2012) Takumi Kiwamoto et al.   PHARMACOLOGY & THERAPEUTICS

Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis

(2012) Fabiola Traina et al.   PLoS One

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines

(2012) M. R. Hepworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New models for analyzing mast cell functions in vivo

(2012) Laurent L. Reber et al.   TRENDS IN IMMUNOLOGY

Cytoskeleton in Mast Cell Signaling

(2012) Pavel Dráber et al.   Frontiers in Immunology

The SNARE Machinery in Mast Cell Secretion

(2012) Axel Lorentz et al.   Frontiers in Immunology

Mast cell transcription factors—Regulators of cell fate and phenotype

(2011) Sagi Tshori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability

(2011) Y. Furumoto et al.   BLOOD

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

(2011) J. N. Lilla et al.   BLOOD

Regulation of mammalian DNA methyltransferases: a route to new mechanisms

(2011) Hélène Denis et al.   EMBO REPORTS

Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

(2011) Anne Dudeck et al.   IMMUNITY

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

(2011) Thorsten B. Feyerabend et al.   IMMUNITY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue

(2011) W. Xing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A key role for ATF3 in regulating mast cell survival and mediator release

(2010) M. Gilchrist et al.   BLOOD

A novel FcεRIβ-chain truncation regulates human mast cell proliferation and survival

(2010) Glenn Cruse et al.   FASEB JOURNAL

Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

(2010) Carole A. Oskeritzian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions

(2010) Kaori Hitomi et al.   NATURE IMMUNOLOGY

Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

(2010) Sandrine Poglio et al.   STEM CELLS

Novel site-specific mast cell subpopulations in the human lung

(2009) C K Andersson et al.   THORAX

Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation

(2008) Kotaro Suzuki et al.   CELL

Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate

(2008) M. Sakata-Yanagimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA