Article
Allergy
Philipp Starkl, Nicolas Gaudenzio, Thomas Marichal, Laurent L. Reber, Riccardo Sibilano, Martin L. Watzenboeck, Frederic Fontaine, Andre C. Mueller, Mindy Tsai, Sylvia Knapp, Stephen J. Galli
Summary: The study found that IgE sensitization enhances MC detoxification of honeybee venom by promoting proteolytic degradation and heparin-related interference with toxicity. This research emphasizes the importance of IgE, MCs, and specific MC products in defense against honeybee venom.
Article
Nutrition & Dietetics
Francesco Savino, Francesca Giuliani, Stefano Giraudi, Ilaria Galliano, Paola Montanari, Valentina Dapra, Massimiliano Bergallo
Summary: The aim of this study was to assess the serum values of IL-4, IL-5, IL-10, and IL-13 in infants with non-IgE mediated food allergies treated with a hydrolyzed formula. The study found that the levels of IL-4 and IL-13 were significantly higher in the non-IgE food allergy group compared to the control group, while IL-5 and IL-10 levels were significantly lower.
Article
Biochemistry & Molecular Biology
Xiaorui Geng, Jinmei Xue, Haoyue Zheng, Limin Suo, Haotao Zeng, Miao Zhao, Shuo Song, Yu Liu, Changqing Zhao, Pingchang Yang
Summary: CD46 contributes to the production of IgE and its activation may be involved in the pathogenesis of allergic diseases. This study found increased CD46 expression in peripheral B cells of patients with allergic rhinitis (AR), which was positively associated with the AR response. Ablation of CD46 in B cells prevented the production of IgE in mice with airway allergy, and exposure to aluminum hydroxide upregulated Cd46 expression. Administration of Cd46 shRNA nanoparticles attenuated experimental airway allergy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Veterinary Sciences
Antonia Fettelschoss-Gabriel, Katharina Birkmann, Stanislav Pantelyushin, Thomas M. Kundig
Summary: This review focuses on the immunopathology and molecular mechanisms of equine Culicoides hypersensitivity, discussing the role of eosinophils and the impact of allergen exposure on T helper cells. The key aspects of CH diagnosis and treatment, including allergen-specific immunotherapy and targeting hypereosinophilia, are also addressed.
VETERINARY JOURNAL
(2021)
Review
Allergy
Julie Wang, David B. K. Golden, David A. Khan
Summary: An accurate diagnosis of IgE-mediated allergies is crucial for managing severe allergic reactions. However, currently available laboratory tests have limitations, especially when it comes to diagnosing drug allergies. Researchers are exploring alternative laboratory testing methods to improve diagnostic accuracy and predict treatment responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Allergy
Moritz M. Hollstein, Silke S. Matzke, Lisa Lorbeer, Susann Forkel, Thomas Fuchs, Christiane Lex, Timo Buhl
Summary: The severity of anaphylaxis in patients with venom allergy cannot be predicted by intracutaneous skin testing and levels of venom-specific IgE. The month of the index sting is not a reliable means to differentiate bee from vespid stings in patients with an uncertain history.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Medicine, Research & Experimental
Jibeom Choi
Summary: Immunity is essential for survival, but can sometimes cause allergic responses to benign stimuli. This study used Bayes' theorem to explain the hygiene hypothesis of allergies and found that infrequent exposure to virulent pathogens in childhood may increase allergic responses.
MEDICAL HYPOTHESES
(2023)
Article
Immunology
Caijie Zhou, Meihua Li, Yu Liu, Xinxin Wang, Shuang Zhang, Li Guan, Jingyi Hong, Wei Zhou, Gaohui Wu, Weiliang Diao, Qinmiao Huang, Pingchang Yang
Summary: TAFA4 can suppress the expression of FcεRI in mast cells to attenuate experimental AR. It is negatively correlated with tryptase levels in nasal secretions and modulates the transcription of Fcer1g gene.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Immunology
Miaomiao Han, Jingyu Ma, Suidong Ouyang, Yanyan Wang, Tingting Zheng, Peishan Lu, Zihan Zheng, Weiheng Zhao, Hongjin Li, Yun Wu, Baohua Zhang, Ran Hu, Kinya Otsu, Xinguang Liu, Ying Wan, Huabin Li, Gonghua Huang
Summary: Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent diseases. Our study identifies p38 alpha signaling as a central pathway in DCs that regulates Th2-cell differentiation and function, integrating allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Christoph Thurm, Burkhart Schraven, Sascha Kahlfuss
Summary: ABC transporters represent a diverse group of ATP-dependent transport proteins that regulate the import and export of various substances. Recent studies have shown that these transporters play a role in the development and function of different T cell populations, impacting immunity to viruses, tumors, and autoimmune diseases. Understanding the function of ABC transporters in T cells may lead to novel therapies for autoimmune disorders and improve immune responses to infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Cheng-Tsung Pan, Chien-Chu Lin, I-Jin Lin, Kun-Yi Chien, Yeong-Shin Lin, Hsiao-Han Chang, Wen-Guey Wu
Summary: For decades, researchers have focused on studying the dominant soluble proteins in snake venom. However, there is still much to learn about the minor venom components, such as snake venom phosphodiesterase (svPDE). In this study, the authors explore svPDE and show that it is derived from a membrane-attached gene and plays a role in purinergic signaling and insulin transduction.
Article
Immunology
Sophie El Abbas, Coraline Radermecker, Qiang Bai, Charline Beguin, Joey Schyns, Margot Meunier, Dimitri Pirottin, Christophe J. Desmet, Marie-Alice Meuwis, Tatiana Art, Edouard Louis, See-Ying Tam, Mindy Tsai, Fabrice Bureau, Stephen J. Galli, Thomas Marichal
MUCOSAL IMMUNOLOGY
(2020)
Article
Allergy
Mindy Tsai, Kaori Mukai, R. Sharon Chinthrajah, Kari C. Nadeau, Stephen J. Galli
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Benjamin L. Wright, Nielsen Q. Fernandez-Becker, Neeraja Kambham, Natasha Purington, Shu Cao, Dana Tupa, Wenming Zhang, Sayantani B. Sindher, Matthew A. Rank, Hirohito Kita, David A. Katzka, Kelly P. Shim, Bryan J. Bunning, Alfred D. Doyle, Elizabeth A. Jacobsen, Mindy Tsai, Scott D. Boyd, Monali Manohar, R. Sharon Chinthrajah
Summary: In this pilot study, peanut OIT-induced EE and gastrointestinal eosinophilia are usually transient and are not always associated with gastrointestinal symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Allergy
Lucy Duan, Alper Celik, Jennifer A. Hoang, Klara Schmidthaler, Delvin So, Xiaojun Yin, Christina M. Ditlof, Marta Ponce, Julia E. M. Upton, Jean-Soo Lee, Lisa Hung, Heimo Breiteneder, Chiara Palladino, Adelle R. Atkinson, Vy H. D. Kim, Alireza Berenjy, Maria Asper, David Hummel, Samantha Wong, Mara Alexanian-Farr, Ahuva Magder, Sharon R. Chinthrajah, Kaori Mukai, Mindy Tsai, Kari Nadeau, Stephen J. Galli, Arun K. Ramani, Zsolt Szepfalusi, Thomas Eiwegger
Summary: The basophil activation test (BAT) can effectively diagnose peanut and tree nut allergies, reducing the need for high-risk OFCs in multi-nut-sensitized children.
Letter
Allergy
Ying Wang, Kazufumi Matsushita, Jennifer Jackson, Takafumi Numata, Yue Zhang, Gao Zhou, Mindy Tsai, Stephen J. Galli
Article
Immunology
Anais Wanet, Mahmoud A. Bassal, Sweta B. Patel, Francisco Marchi, Samanta A. Mariani, Nouraiz Ahmed, Haoran Zhang, Marta Borchiellini, Sisi Chen, Junyan Zhang, Annalisa Di Ruscio, Kensuke Miyake, Mindy Tsai, Anuya Paranjape, Shin-Young Park, Hajime Karasuyama, Timm Schroeder, Elaine Dzierzak, Stephen J. Galli, Daniel G. Tenen, Robert S. Welner
Summary: E-cadherin expression in the hematopoietic system was studied using single-cell RNA-sequencing analyses and immunophenotyping. High levels of E-cadherin were found in progenitors within the granulocyte-monocyte progenitors (GMPs) fraction, with an enriched capacity to differentiate into basophils and mast cells. The transcriptional priming of these progenitors to the basophil and mast cell lineages was observed, with GATA-2 directly regulating E-cadherin expression in these lineages.
SCIENCE IMMUNOLOGY
(2021)
Article
Allergy
Philipp Starkl, Nicolas Gaudenzio, Thomas Marichal, Laurent L. Reber, Riccardo Sibilano, Martin L. Watzenboeck, Frederic Fontaine, Andre C. Mueller, Mindy Tsai, Sylvia Knapp, Stephen J. Galli
Summary: The study found that IgE sensitization enhances MC detoxification of honeybee venom by promoting proteolytic degradation and heparin-related interference with toxicity. This research emphasizes the importance of IgE, MCs, and specific MC products in defense against honeybee venom.
Article
Immunology
Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophelie Godon, Thomas Marichal, Philipp Starkl, Bianca Balbino, Axel Roers, Pierre Bruhns, Friederike Jonsson, Philippe Moguelet, Sophie Georgin-Lavialle, Lori Broderick, Hal M. Hoffman, Stephen J. Galli, Laurent L. Reber
Summary: Gain-of-function mutations in NLRP3 gene cause CAPS, with neutrophils potentially being the main cellular drivers of CAPS pathology.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Kazufumi Matsushita, Xin Li, Yuki Nakamura, Danyue Dong, Kaori Mukai, Mindy Tsai, Stephen B. Montgomery, Stephen J. Galli
Summary: By studying 47 CC strains, we identified significant variations in IgE and MC activity in vivo, C57BL/6J and CC027 were found to be effective models for studying MC functions, and Sp140 was identified as a gene contributing to IgE-dependent MC activation.
Article
Medicine, General & Internal
Christopher Michael Warren, Theo Thomas Snow, Alexandra S. Lee, Mihir Mukesh Shah, Anja Heider, Andra Blomkalns, Brooke Betts, Anthony S. Buzzanco, Joseph Gonzalez, R. Sharon Chinthrajah, Evan Do, Iris Chang, Diane Dunham, Grace Lee, Ruth O'Hara, Helen Park, Mohamed H. Shamji, Lisa Schilling, Sayantani B. Sindher, Deepak Sisodiya, Eric Smith, Mindy Tsai, Stephen J. Galli, Cezmi Akdis, Kari C. Nadeau
Summary: This study analyzed 22 patients with suspected allergic reactions to mRNA COVID-19 vaccines, indicating a potential non-IgE mediated immune response to PEG in most individuals. Women and those with a history of allergic reactions may have an elevated risk of mRNA vaccine allergy.
Review
Allergy
Mindy Tsai, Peter Valent, Stephen J. Galli
Summary: The discovery of the cell surface receptor KIT and its ligand, stem cell factor (SCF), in 1987/1988 and 1990 has greatly contributed to our understanding of the development and function of various cell lineages. Mutations in KIT or SCF can have significant effects on the development and/or function of hematopoietic progenitors, melanocytes, germ cells, and mast cells. The biological importance of KIT in other cell types is still not well understood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Nicolas Castano, Kaiser Chua, Abhinav Kaushik, Sungu Kim, Seth C. Cordts, Ceena D. Nafarzadegan, Grady H. Hofmann, Hana Seastedt, Jackson P. Schuetz, Diane Dunham, Ella S. Parsons, Mindy Tsai, Shu Cao, Manisha Desai, Sayantani B. Sindher, R. Sharon Chinthrajah, Stephen J. Galli, Kari C. Nadeau, Sindy K. Y. Tang
Summary: Avidin and CD63 have been found to be reliable basophil activation markers that enhance the identification of activated basophils and improve the classification accuracy of peanut allergy.
Article
Biochemical Research Methods
Nora Vivanco Gonzalez, John-Paul Oliveria, Dmitry Tebaykin, Geoffrey T. Ivison, Kaori Mukai, Mindy M. Tsai, Luciene Borges, Kari C. Nadeau, Stephen J. Galli, Albert G. Tsai, Sean C. Bendall
Summary: This study utilized mass cytometry to capture distinct phenotypes of granulocytes, and through optimized protocols, achieved in-depth characterization of basophils, eosinophils, and neutrophils. This research is of great significance for understanding the roles of granulocytes in homeostasis and immune activation.
Meeting Abstract
Allergy
Sharon Chinthrajah, Shu Cao, Mindy Tsai, Kaori Mukai, Robert Tibshirani, Sayantani Sindher, Kari Nadeau, Stephen Galli
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)