期刊
TRENDS IN IMMUNOLOGY
卷 33, 期 12, 页码 613-625出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.09.008
关键词
basophils; c-kit; mouse model; Cre recombinase
类别
资金
- French Fondation pour la Recherche Medicale FRM
- Stanford Pediatric Research Fund
- Arthritis National Research Foundation [SPO106496]
- Belgium American Educational Foundation
- Marie Curie International outgoing Fellowship for Career Development
- National Institutes of Health [AI023990, CA072074, AI070813]
In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that contribute to disease or help to maintain health. Although some of these roles were first suggested by analyses of MC products or functions in vitro, it is critical to determine whether, and under which circumstances, such potential roles actually can be performed by MCs in vivo. This review discusses recent advances in the development and analysis of mouse models to investigate the roles of MCs and MC-associated products during biological responses in vivo, and comments on some of the similarities and differences in the results obtained with these newer versus older models of MC deficiency.
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