Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors

Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action

(2016) Maria Luisa Villalba et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds

(2016) Bünyamin Özgeriş et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII

(2016) Elisabetta Barresi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds

(2016) Adel S. El-Azab et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety

(2016) Samaneh Ghanei-Nasab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies

(2016) Benedetta Cornelio et al.   JOURNAL OF MEDICINAL CHEMISTRY

The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain

(2016) Silvia Fossati et al.   NEUROBIOLOGY OF DISEASE

New natural product carbonic anhydrase inhibitors incorporating phenol moieties

(2015) Anastasia Karioti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives

(2015) İsmail Fidan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII

(2015) Alessio Nocentini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: Novel sulfamoylcarbamates and sulfamides derived from acetophenones

(2015) Akın Akıncıoğlu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives

(2015) Semra Işık et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor

(2015) Syahrul Imran et al.   BIOORGANIC CHEMISTRY

Kinetic andin silicostudies of hydroxy-based inhibitors of carbonic anhydrase isoforms I and II

(2015) Ramin Ekhteiari Salmas et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

In silicoinvestigation of PARP-1 catalytic domains inholoandapostates for the design of high-affinity PARP-1 inhibitors

(2015) Ramin Ekhteiari Salmas et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis of Some Novel Norbornene-Fused Pyridazines as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase

(2015) Ramazan Kocak et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins

(2015) Marta Ferraroni et al.   JOURNAL OF MEDICINAL CHEMISTRY

6-Substituted Sulfocoumarins Are Selective Carbonic Anhdydrase IX and XII Inhibitors with Significant Cytotoxicity against Colorectal Cancer Cells

(2015) Aiga Grandane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I–XIV

(2015) Fabrizio Carta et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use

(2015) Jaromir Pastorek et al.   SEMINARS IN CANCER BIOLOGY

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series

(2015) Joanna Ombouma et al.   ACS Medicinal Chemistry Letters

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

(2014) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New aminobenzenesulfonamide–thiourea conjugates: Synthesis and carbonic anhydrase inhibition and docking studies

(2014) Sumera Zaib et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of coumarin-3-acylamino derivatives to scavenge radicals and to protect DNA

(2014) Yang Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Insights on Carbonic Anhydrase Inhibitory Action, Isoform Selectivity, and Potency of Sulfonamides and Coumarins Incorporating Arylsulfonylureido Groups

(2014) Murat Bozdag et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects

(2014) Murat Bozdag et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tumor Microenvironmental Changes Induced by the Sulfamate Carbonic Anhydrase IX Inhibitor S4 in a Laryngeal Tumor Model

(2014) Tineke W. H. Meijer et al.   PLoS One

7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors

(2013) Muhammet Tanc et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies

(2013) Serdar Durdagi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX

(2013) Aditi Sharma et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition

(2012) Isao Nishimori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfocoumarins (1,2-Benzoxathiine-2,2-dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases

(2012) Kaspars Tars et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors and activators for novel therapeutic applications

(2011) Claudiu T Supuran   Future Medicinal Chemistry

Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors

(2011) Nadia Touisni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis

(2011) Fabio Pacchiano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations

(2010) Jason Wagner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

7,8-Disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

(2010) Alfonso Maresca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drug Design Studies of the Novel Antitumor Targets Carbonic Anhydrase IX and XII

(2010) O. Guler et al.   CURRENT MEDICINAL CHEMISTRY

Modulation of Carbonic Anhydrase 9 (CA9) in Human Brain Cancer

(2010) Harun M. Said et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia

(2010) Vamsidhar Akurathi et al.   NUCLEAR MEDICINE AND BIOLOGY

Design of a Carbonic Anhydrase IX Active-Site Mimic To Screen Inhibitors for Possible Anticancer Properties†‡

(2009) Caroli Genis et al.   BIOCHEMISTRY

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target

(2009) Giuseppina De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

(2009) Alfonso Maresca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors#

(2009) Alfonso Maresca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Developments of Carbonic Anhydrase Inhibitors as Potential Anticancer Drugs

(2008) Anne Thiry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY