Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

Redox Roles of Reactive Oxygen Species in Cardiovascular Diseases

(2015) Feng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse

(2015) Daniel S. Lark et al.   PLoS One

Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II

(2015) Daniela Macconi et al.   PLoS One

The effect of high-fat–high-fructose diet on skeletal muscle mitochondrial energetics in adult rats

(2014) Raffaella Crescenzo et al.   EUROPEAN JOURNAL OF NUTRITION

Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle

(2014) Bruno G. Teodoro et al.   JOURNAL OF PINEAL RESEARCH

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

(2014) M. A. Soliman et al.   Science Signaling

Increased skeletal muscle mitochondrial efficiency in rats with fructose-induced alteration in glucose tolerance

(2013) Raffaella Crescenzo et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans

(2013) K. H. Fisher-Wellman et al.   DIABETES

Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases

(2013) G. K. Sakellariou et al.   FREE RADICAL RESEARCH

Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

(2013) Shingo Takada et al.   JOURNAL OF APPLIED PHYSIOLOGY

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and morphological impact of ER stress on mitochondria

(2013) Kayleen Vannuvel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial metabolism of reactive oxygen species

(2013) Paola Venditti et al.   MITOCHONDRION

Subsarcolemmal and intermyofibrillar mitochondrial responses to short-term high-fat feeding in rat skeletal muscle

(2013) Raffaella Crescenzo et al.   NUTRITION

Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

(2013) Larysa V. Yuzefovych et al.   PLoS One

Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

(2013) Imtiaz A. Samjoo et al.   PLoS One

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle

(2013) E.P. Taddeo et al.   Molecular Metabolism

Studies of Mitochondrial and Nonmitochondrial Sources Implicate Nicotinamide Adenine Dinucleotide Phosphate Oxidase(s) in the Increased Skeletal Muscle Superoxide Generation That Occurs During Contractile Activity

(2012) Giorgos Konstantinos Sakellariou et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in insulin resistance: differential contributions of chronic insulin and saturated fatty acid exposure in muscle cells

(2012) Chenjing Yang et al.   BIOSCIENCE REPORTS

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

Early Mitochondrial Adaptations in Skeletal Muscle to Diet-Induced Obesity Are Strain Dependent and Determine Oxidative Stress and Energy Expenditure But Not Insulin Sensitivity

(2012) Sihem Boudina et al.   ENDOCRINOLOGY

Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity

(2012) Y Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity, insulin resistance, and skeletal muscle nitric oxide synthase

(2012) Raymond M. Kraus et al.   JOURNAL OF APPLIED PHYSIOLOGY

Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

(2012) Yolanda Gómez-Pérez et al.   Nutrition & Metabolism

Overfeeding Reduces Insulin Sensitivity and Increases Oxidative Stress, without Altering Markers of Mitochondrial Content and Function in Humans

(2012) Dorit Samocha-Bonet et al.   PLoS One

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of intramyocelluar lipids in human health

(2012) Paul M. Coen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

(2011) Ana P. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1

(2011) Magali Balteau et al.   CARDIOVASCULAR RESEARCH

The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery

(2011) Catherine S. Palmer et al.   CELLULAR SIGNALLING

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)–nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction

(2011) R. Barazzoni et al.   DIABETOLOGIA

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

(2011) Shengnan Wu et al.   FEBS Journal

Protein sulfenic acid formation: From cellular damage to redox regulation

(2011) Goedele Roos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation and neurodegenerative disease

(2011) Tanea T. Reed   FREE RADICAL BIOLOGY AND MEDICINE

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction in patients with primary congenital insulin resistance

(2011) Alison Sleigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

The renin-angiotensin system: a link between obesity, inflammation and insulin resistance

(2011) N. S. Kalupahana et al.   Obesity Reviews

Concentration-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes

(2011) Satoshi Iwakami et al.   PLoS One

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

(2011) E. Jing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Functions of Reactive Oxygen Species

(2010) Henry Jay Forman et al.   BIOCHEMISTRY

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

(2010) Andreas Daiber   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

(2010) C De Palma et al.   CELL DEATH AND DIFFERENTIATION

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Reduction in Hexokinase II Levels Results in Decreased Cardiac Function and Altered Remodeling After Ischemia/Reperfusion Injury

(2010) Rongxue Wu et al.   CIRCULATION RESEARCH

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance

(2010) J. Hoeks et al.   DIABETES

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

H2O2-induced mitochondrial fragmentation in C2C12 myocytes

(2010) Xiying Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and the etiology of insulin resistance and type 2 diabetes

(2010) Erik J. Henriksen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Normal mitochondrial function and increased fat oxidation capacity in leg and arm muscles in obese humans

(2010) I Ara et al.   INTERNATIONAL JOURNAL OF OBESITY

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

(2010) Erik Schoenmakers et al.   JOURNAL OF CLINICAL INVESTIGATION

NOX/NADPH Oxidase, the Superoxide-Generating Enzyme: Its Transcriptional Regulation and Physiological Roles

(2010) Masato Katsuyama   JOURNAL OF PHARMACOLOGICAL SCIENCES

Endotoxin Mediated-iNOS Induction Causes Insulin Resistance via ONOO− Induced Tyrosine Nitration of IRS-1 in Skeletal Muscle

(2010) Geneviève Pilon et al.   PLoS One

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanism

(2010) Maggie K. Diamond-Stanic et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Age, Obesity, and Sex Effects on Insulin Sensitivity and Skeletal Muscle Mitochondrial Function

(2009) H. Karakelides et al.   DIABETES

Physical Inactivity and Obesity Underlie the Insulin Resistance of Aging

(2009) F. Amati et al.   DIABETES CARE

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased Superoxide Production in Macrophages of Long-lived p66Shc Knock-out Mice

(2009) Alexey A. Tomilov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

(2009) Sandro M. Hirabara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial Function and Insulin Resistance in Overweight and Normal-Weight Children

(2009) Amy Fleischman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction

(2009) Lisa Chow et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Insulin resistance is a cellular antioxidant defense mechanism

(2009) K. L. Hoehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Reduction of mitochondrial H2O2by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

(2008) Liuji Chen et al.   AGING CELL

O2-sensing signal cascade: clamping of O2 respiration, reduced ATP utilization, and inducible fumarate respiration

(2008) Vijayalakshmi Sridharan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences

(2008) S. de Ferranti et al.   CLINICAL CHEMISTRY

Angiotensin II Reduces Mitochondrial Content in Skeletal Muscle and Affects Glycemic Control

(2008) M. Mitsuishi et al.   DIABETES

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

(2008) E. Phielix et al.   DIABETES

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

(2008) H M De Feyter et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes

(2008) Henk M. De Feyter et al.   FASEB JOURNAL

Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high-fat feeding

(2008) Joris Hoeks et al.   FEBS LETTERS

Fatty acids as modulators of the cellular production of reactive oxygen species

(2008) Peter Schönfeld et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of p66Shc deletion in age-associated arterial dysfunction and disease states

(2008) Giovanni G. Camici et al.   JOURNAL OF APPLIED PHYSIOLOGY

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells

(2008) Alejandra Espinosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria

(2008) F. Camões et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Activation of the lifespan regulator p66Shc through reversible disulfide bond formation

(2008) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation

(2007) Stephen M. Black et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of Proliferation of Skeletal Muscle Precursor Cells By NADPH Oxidase

(2007) Mahroo Mofarrahi et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction

(2007) Abdulrahman K. Doughan et al.   CIRCULATION RESEARCH

Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice

(2007) Janneke de Wilde et al.   PHYSIOLOGICAL GENOMICS