Review
Biochemistry & Molecular Biology
Stefania Merighi, Manuela Nigro, Alessia Travagli, Stefania Gessi
Summary: Neuroinflammation may be a crucial avenue for treating and preventing Alzheimer's disease, with microglia playing a key role in the disease process but potentially becoming impaired in later stages. It is important to identify new biomarkers to assess microglial activity and develop novel therapies to restore their physiological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Dieli
Summary: The inflammatory response in Alzheimer's disease has both protective and harmful effects. Microglia initially play a protective role but can become overactivated, leading to impaired clearance of β-amyloid peptides and neurodegeneration. Microglia also contribute to the spread of tau pathology. Elevated levels of soluble TREM2 in cerebrospinal fluid are associated with amyloid plaque burden, neurodegeneration, and cognitive decline. Understanding the relationship between innate immunity and Alzheimer's disease could lead to new diagnostic and therapeutic approaches, but further studies are needed for effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wang
Summary: Alzheimer's disease is a common neurodegenerative disease that leads to cognitive decline and memory loss. Current treatments only provide symptom relief and do not reverse the disease. Studies have shown that TREM2, predominantly expressed in microglia of the central nervous system, plays a protective role by regulating microglial function and promoting the clearance of toxic substances. However, the specific mechanism of action is not fully understood.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Lucia Scipioni, Francesca Ciaramellano, Veronica Carnicelli, Alessandro Leuti, Anna Rita Lizzi, Noemi De Dominicis, Sergio Oddi, Mauro Maccarrone
Summary: This article reviews the role of microglial cells in chronic inflammation in Alzheimer's disease (AD) and the involvement of endocannabinoids in regulating their activity.
Review
Biochemistry & Molecular Biology
Akash Shah, Uday Kishore, Abhishek Shastri
Summary: This article discusses how the complement system plays a role in the functioning of the central nervous system, while also contributing to chronic neuroinflammation leading to neurodegenerative disorders like Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Laura D. Owlett, Berke Karaahmet, Linh Le, Elizabeth K. Belcher, Dawling Dionisio-Santos, John A. Olschowka, Michael R. Elliott, M. Kerry O'Banion
Summary: Gas6 overexpression reduces plaque burden but increases pro-inflammatory signaling and worsens behavior in an Alzheimer's disease model. Gas6 overexpression appears to have no effect on phagocytic mechanisms in vitro or in vivo.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong He
Summary: This study investigates the role of MKP-1 in regulating microglia phenotype and inflammatory factor release in Alzheimer's disease (AD). The findings suggest that MKP-1 can modulate microglia phenotype and inflammatory factor release in AD through the p38 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Rawan Almarhoumi, Carla Alvarez, Theodore Harris, Christina M. Tognoni, Bruce J. Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci
Summary: In this study, periodontal disease (PD) was induced in mice and it was found that PD leads to activation of microglia and promotes a pro-inflammatory and phagocytic phenotype in the microglia.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Mulan Bao, Rengui Bade, Hua Liu, Battseren Tsambaa, Guo Shao, Almaz Borjigidai, Yong Cheng
Summary: AS-IV from Huangqi may regulate inflammation and microglial activation in AD via EGFR-dependent pathways. EGFR and IL-113 could be important targets that co-regulate downstream molecular functions in the treatment of AD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Yi-He Chen, Rong-Rong Lin, Qing-Qing Tao
Summary: Alzheimer's disease is the most common cause of dementia and is increasing with global aging trends. In addition to the known core pathologies of AD, neuroinflammation has been recognized as playing an important role. Recent evidence has shown that P2X7R plays a critical role in neuroinflammation and AD pathogenesis.
Article
Biotechnology & Applied Microbiology
Liang Tang, Qin Xiang, Ju Xiang, Yan Zhang, Jianming Li
Summary: The study aimed to explore the effect of Tripterygium glycoside (TG) on Alzheimer's disease (AD). The results showed that TG significantly improved spatial memory and learning abilities in AD mice, reduced neuronal damage, and inhibited the release of inflammatory factors and microglial activity.
Article
Materials Science, Multidisciplinary
Ze Li, Zhenyan Song, Chunxiang He, Jialong Fan, Wenjing Yu, Miao Yang, Ping Li, Rongsiqing Luo, Jinyong Zhou, Sijie Xu, Bin Liu, Shaowu Cheng
Summary: This study developed a nano delivery system that can reverse microglia polarization, improve learning and memory, alleviate glial cell activation, and enhance cognitive function in Alzheimer's disease treatment, indicating its promising therapeutic potential.
MATERIALS TODAY ADVANCES
(2022)
Review
Immunology
Deepali Singh
Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Eunji Oh, Jeong-Hwa Kang, Kyung Won Jo, Won-Sik Shin, Young-Hun Jeong, Byunghee Kang, Tae-Young Rho, So Yeon Jeon, Jihoon Lee, Im-Sook Song, Kyong-Tai Kim
Summary: In this study, a synthetic peroxisome proliferator-activating receptor (PPAR) agonist called DTMB was found to improve chronic inflammation and A beta plaque progression, suggesting its potential as a novel therapeutic agent for Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Anna Hau-Yee Kong, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Maggie Ming-Ki Leung, Alexis Shiying Huang, Yuanyuan Yu, Ge Zhang, Aiping Lyu, Min Li, King-Ho Cheung
Summary: Neuroinflammation is a precursor to neurodegenerative diseases, and targeting it with aptamers offers potential diagnostic and therapeutic applications. This review summarizes the use of aptamers for diagnosing and treating inflammatory biomolecules and cells associated with neurodegenerative diseases. It also discusses the potential of short nucleotides for targeted brain delivery and the challenges of using aptamers as therapeutic agents. Overall, this review assesses the potential of aptamers as a pioneering approach for CNS target delivery and the treatment of neuroinflammation and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Siti Hajar Rehiman, Siong Meng Lim, Fei Tieng Lim, Ai-Vyrn Chin, Maw Pin Tan, Shahrul Bahyah Kamaruzzaman, Kalavathy Ramasamy, Abu Bakar Abdul Majeed
Summary: This study identified differential protein expression of fibrinogen isoforms in patients with Alzheimer's disease (AD) and found a weak but significant correlation between fibrinogen and cognitive decline. This suggests that fibrinogen may serve as a promising blood-based biomarker for AD.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Vasudevan Mani, Nur Syamimi Mohd Azahan, Kalavathy Ramasamy, Siong Meng Lim, Abu Bakar Abdul Majeed
Summary: Mahanimbine has positive effects on memory function, oxidative stress, cholinergic function, amyloid formation, and neuroinflammation in aged mice. It improves spatial learning and memory retention, and reduces levels of markers associated with neurodegenerative diseases.
Article
Pharmacology & Pharmacy
Ravi Sheshala, Ng Zing Wai, Iqbal Danial Said, Kamran Ashraf, Siong Meng Lim, Kalavathy Ramasamy, Farrukh Zeeshan
Summary: This study fabricated poloxamer and chitosan-based in situ gels loaded with OS leaf extracts and evaluated their antimicrobial efficacy. One of the formulations showed modest antimicrobial activity against Micrococcus luteus, but sedimentation occurred after loading into the gel.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Saurabh Bhatia, Rashita Makkar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Mahesh Rachamalla, Vasudevan Mani, Muhammad Shahid Iqbal, Simona Gabriela Bungau
Summary: Marine drugs, with their diverse structures and mechanisms of action, offer new treatment approaches for chronic diseases. The marine ecosystem is a rich source of bioactive compounds, leading to the development of novel therapeutic targets. Drugs derived from marine sources have shown exceptional potential in managing a wide array of diseases, especially chronic conditions. Marine drugs play an important role in human health.
Review
Biochemistry & Molecular Biology
Tapan Behl, Amit Gupta, Sridevi Chigurupati, Sukhbir Singh, Aayush Sehgal, Vishnu Nayak Badavath, Ahmad Alhowail, Vasudevan Mani, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau
Summary: Reactive carbonyl species (RCS) are oxidation products of unsaturated fatty acids and sugar under pathological conditions, with high reactivity towards DNA and proteins leading to cellular dysfunction. Regulating RCS levels may be beneficial for metabolic and neurodegenerative disorders.
Article
Clinical Neurology
Tarapati Rana, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Ahmed Abdeen, Samah F. Ibrahim, Vasudevan Mani, Muhammad Shahid Iqbal, Saurabh Bhatia, Mohamed M. Abdel Daim, Simona Bungau
Summary: Depression is a common mental disorder with significant social and economic impacts. Finding new treatment strategies, particularly targeting neuropeptides, has become crucial in neurobiology.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Vasudevan Mani, Minhajul Arfeen, Hamdoon A. Mohammed, Hossam A. Elsisi, Sultan Sajid, Yasser Almogbel, Maha Aldubayan, Muralikrishnan Dhanasekaran, Ahmad Alhowail
Summary: This study evaluated the effect of aqueous sukkari dates seed extract (ASSE) on T2DM-induced rats. The results showed that ASSE has potential benefits in improving memory function and blood glucose control, which are comparable to metformin treatment.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Nor Amalina Ahmad Alwi, Siong Meng Lim, Vasudevan Mani, Kalavathy Ramasamy
Summary: This study investigates the mechanisms underlying enhanced memory in transgenic mice supplemented with probiotics. The results show that mice supplemented with probiotics perform better in the Morris Water Maze test, and the improved memory may be attributed to reduced amyloidogenesis and antioxidative effects.
JOURNAL OF DIETARY SUPPLEMENTS
(2023)
Article
Biology
Nor Raihan Mohammad Shabani, Che Muhammad Khairul Hisyam Ismail, Amy Amilda Anthony, Chiuan Herng Leow, Candy Chuah, Abu Bakar Abdul Majeed, Norazmi Mohd Nor, Yongqun He, Kirnpal Kaur Banga Singh, Chiuan Yee Leow
Summary: This study aims to identify peptides that could be ideal candidates for the development of a Shigella vaccine. By analyzing and identifying bacterial peptides bound to infected THP-1 cells, several proteins were predicted to be outer membrane proteins (OMPs) of Shigella and potential peptide candidates for the vaccine. The outer membrane receptors FepA and TonB were found to possess a high number of immunogenic epitopes and may be suitable for further vaccine development.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Plant Sciences
Vasudevan Mani, Minhajul Arfeen, Devendra Kumar Dhaked, Hamdoon A. Mohammed, Palanisamy Amirthalingam, Hossam A. Elsisi
Summary: Islamic literature has shown that daily consumption of Ajwa dates can treat various chronic diseases. This study investigated the neuroprotective effect of methanolic Ajwa seed extract (MASE) on LPS-induced cognitive deficits. The results demonstrated that MASE reversed LPS-induced memory impairment, increased acetylcholine levels, and reduced neuroinflammatory markers in the rat brain. These findings contribute to the discovery of drugs for neuroinflammation-related neurodegenerative diseases.
Article
Multidisciplinary Sciences
Nur Farahani Zolkiflee, Meor Mohd Redzuan Meor Mohd Affandi, Abu Bakar Abdul Majeed
Summary: In this study, the thermodynamic parameters of solute-solvent and solute-cosolute interactions in the ternary system (LCTZ + water + amino acids) were elucidated. The calculated constants provided a detailed understanding of the different types of intermolecular interactions found in the system.
Article
Biochemistry & Molecular Biology
Vasudevan Mani, Bander Shehail Alshammeri
Summary: Chemotherapy is a common cancer treatment, but it can lead to cognitive deficiencies and psychiatric complications. A study found that the antipsychotic drug quetiapine can improve cognitive deficits caused by chemotherapy. It works by reducing neuronal inflammation and protecting against oxidative stress, thus protecting neurons from damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Vasudevan Mani, Salem Rashed Almutairi
Summary: This study aimed to investigate the protective effects of levetiracetam against lipopolysaccharide-induced cognitive impairment and explore the underlying mechanisms. The results showed that levetiracetam could increase acetylcholine levels, reduce neuroinflammation, cellular apoptosis, and oxidative stress, suggesting its potential in treating neuroinflammatory-related memory loss.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Muhamad Fareez Ismail, Siong Meng Lim, Fei Tieng Lim, Kalavathy Ramasamy
Summary: This study demonstrated the enhanced thermal stability and pH-sensitive release of the probiotic strain Lactiplantibacillus plantarum LAB12 through microencapsulation using alginate and denatured pea protein isolate. The microencapsulated LAB12 showed high viability even at high temperature and low pH, and exhibited optimal release in simulated intestinal fluid. Microencapsulation also provided additional benefits such as cholesterol reduction in zebrafish fed with a high-cholesterol diet. Overall, the findings suggest that Alg-PPi10 could be an effective medium for the applications of LAB12 in various industries.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)