DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA

(2016) Sarah Eddy et al.   BIOCHEMISTRY

Pathological trans-lesion synthesis in cancer

(2016) Yanzhe Gao et al.   CELL CYCLE

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathwayin vivo

(2016) Yang Yang et al.   NUCLEIC ACIDS RESEARCH

Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

(2016) Emmanuelle Despras et al.   Nature Communications

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

(2016) Yanzhe Gao et al.   Nature Communications

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

(2016) Laura Garcia-Exposito et al.   Cell Reports

Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance

(2015) Mark Hedglin et al.   Annual Review of Biophysics

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase

(2015) Nandini Sakurikar et al.   Oncotarget

Replication of Structured DNA and its implication in epigenetic stability

(2015) Valentina Cea et al.   Frontiers in Genetics

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

(2014) Camilo Guzmán et al.   PLoS One

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

(2013) K. J. Neelsen et al.   GENES & DEVELOPMENT

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

(2013) Michael Durando et al.   NUCLEIC ACIDS RESEARCH

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

(2013) Yang Yang et al.   NUCLEIC ACIDS RESEARCH

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress

(2013) Seetha V. Srinivasan et al.   Cell Reports

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

(2012) H. Beck et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI

(2011) S. A. Williams et al.   BLOOD

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

(2011) Komaraiah Palle et al.   CELL CYCLE

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

(2011) Marie Regairaz et al.   JOURNAL OF CELL BIOLOGY

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

(2011) David W. Schoppy et al.   JOURNAL OF CLINICAL INVESTIGATION

The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

(2011) Anastasia Zlatanou et al.   MOLECULAR CELL

NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis

(2011) Hiromi Yanagihara et al.   MOLECULAR CELL

SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis

(2011) Jia-Ren Lin et al.   MOLECULAR CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

(2011) C. S. Sorensen et al.   NUCLEIC ACIDS RESEARCH

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

(2011) Kristen L. Meerbrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

(2010) Halfdan Beck et al.   JOURNAL OF CELL BIOLOGY

Phosphorylated Rad18 directs DNA Polymerase η to sites of stalled replication

(2010) Tovah A. Day et al.   JOURNAL OF CELL BIOLOGY

CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

(2010) Kenta Terai et al.   MOLECULAR CELL

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

(2009) Asami Hishiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

(2008) Yuri Tsuji et al.   GENES TO CELLS

Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

(2008) Adelina A. Davies et al.   MOLECULAR CELL

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE