Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer

(2016) Oren Levy et al.   BIOMATERIALS

Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours

(2016) D Mahalingam et al.   BRITISH JOURNAL OF CANCER

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Modulation of intracellular calcium homeostasis blocks autophagosome formation

(2013) Nikolai Engedal et al.   Autophagy

Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells

(2013) Charlotte Dubois et al.   FEBS Journal

Unfolded Protein Response Signaling and Metabolic Diseases

(2013) Jaemin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracing Cytoplasmic Ca2+ Ion and Water Access Points in the Ca2+-ATPase

(2012) Maria Musgaard et al.   BIOPHYSICAL JOURNAL

Engineering a Prostate-Specific Membrane Antigen-Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

(2012) S. R. Denmeade et al.   Science Translational Medicine

Critical Roles of Hydrophobicity and Orientation of Side Chains for Inactivation of Sarcoplasmic Reticulum Ca2+-ATPase with Thapsigargin and Thapsigargin Analogs

(2010) Anne-Marie L. Winther et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sarcoplasmic Ca2+-ATPase: design of a perfect chemi-osmotic pump

(2010) Jesper V. Møller et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

(2010) M Flourakis et al.   Cell Death & Disease

STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals

(2009) Xiaoxiang Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells

(2009) D. J. Vander Griend et al.   MOLECULAR CANCER THERAPEUTICS

Intracellular death platform steps-in: Targeting prostate tumors via endoplasmic reticulum (ER) apoptosis

(2008) Steven R. Schwarze et al.   PROSTATE