STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM protein coupling in the activation of Orai channels

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Location and Function of STIM1 in the Activation of Ca2+Entry Signals

(2008) Thamara Hewavitharana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Store-dependent and -independent Modes Regulating Ca2+Release-activated Ca2+Channel Activity of Human Orai1 and Orai3

(2008) Shenyuan L. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size

(2008) Rainer Schindl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

(2008) Peter B. Stathopulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+-store-dependent and -independent reversal of Stim1 localization and function

(2008) J. T. Smyth et al.   JOURNAL OF CELL SCIENCE

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

(2008) Christine Peinelt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Clustering of STIM1 with Orai1/CRACM1 at the Plasma Membrane Depends Dynamically on Depletion of Ca2+ Stores and on Electrostatic Interactions

(2008) Nathaniel Calloway et al.   MOLECULAR BIOLOGY OF THE CELL

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

Functional stoichiometry of the unitary calcium-release-activated calcium channel

(2008) W. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

(2007) Suhel Parvez et al.   FASEB JOURNAL

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON