The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

(2016) Isabel Denzer et al.   PHARMACOLOGICAL RESEARCH

Nrf2 as a master regulator of tissue damage control and disease tolerance to infection

(2015) Miguel P. Soares et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

(2015) Maria A. O’Connell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

(2015) M.-C. Laiguillon et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolic stress-induced joint inflammation and osteoarthritis

(2015) A. Courties et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolic triggered inflammation in osteoarthritis

(2015) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

(2015) Danielle R. Bruns et al.   Oxidative Medicine and Cellular Longevity

The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications

(2015) Christian Herder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1

(2015) Tsuyoshi Takada et al.   ARTHRITIS RESEARCH & THERAPY

Heme oxygenase and the immune system in normal and pathological pregnancies

(2015) Maide Ozen et al.   Frontiers in Pharmacology

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

(2014) Manish Mishra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Does broccoli protect from osteoarthritis?

(2014) Francis Berenbaum   JOINT BONE SPINE

The association of oxidative stress and pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis

(2014) Juan Li et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis

(2014) Marie-Charlotte Laiguillon et al.   ARTHRITIS RESEARCH & THERAPY

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

(2014) Liang-Jun Yan   Journal of Diabetes Research

Sulforaphane Represses Matrix-Degrading Proteases and Protects Cartilage From Destruction In Vitro and In Vivo

(2013) Rose K. Davidson et al.   ARTHRITIS AND RHEUMATISM

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

(2013) Victoria Clérigues et al.   CLINICAL SCIENCE

Gestational Diabetes Mellitus Impairs Nrf2-Mediated Adaptive Antioxidant Defenses and Redox Signaling in Fetal Endothelial Cells In Utero

(2013) X. Cheng et al.   DIABETES

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of heme oxygenase-1 on bacterial antigen-induced articular chondrocyte catabolism in vitro

(2013) Taro Mawatari et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

(2013) Hyun-Ae Seo et al.   Oxidative Medicine and Cellular Longevity

Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes

(2013) Francis Rousset et al.   PLoS One

Allergic Skin Inflammation Induced by Chemical Sensitizers Is Controlled by the Transcription Factor Nrf2

(2013) Zeina El Ali et al.   TOXICOLOGICAL SCIENCES

Number of circulating pro-angiogenic cells, growth factor and anti-oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome

(2013) Witold N Nowak et al.   Journal of Diabetes Investigation

Emerging Role of Nrf2 in Adipocytes and Adipose Biology

(2013) Kevin S. Schneider et al.   Advances in Nutrition

Rebamipide Suppresses Collagen-Induced Arthritis Through Reciprocal Regulation of Th17/Treg Cell Differentiation and Heme Oxygenase 1 Induction

(2013) Su-Jin Moon et al.   Arthritis & Rheumatology

The Predicted Molecular Weight of Nrf2: It Is What It Is Not

(2012) Alexandria Lau et al.   ANTIOXIDANTS & REDOX SIGNALING

Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study

(2012) G. Schett et al.   DIABETES CARE

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation

(2012) H.-A. Kim et al.   RHEUMATOLOGY

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

(2011) Milad S. Bitar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype

(2011) F. Berenbaum   ANNALS OF THE RHEUMATIC DISEASES

Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease

(2011) Nuria Maicas et al.   ANTIOXIDANTS & REDOX SIGNALING

Bach1 regulates osteoclastogenesis in a mouse model via both heme oxygenase 1-dependent and heme oxygenase 1-independent pathways

(2011) Maasa Hama et al.   ARTHRITIS AND RHEUMATISM

Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts

(2011) Victoria Clérigues et al.   BIOCHEMICAL PHARMACOLOGY

Prevalence of symptomatic hip and knee osteoarthritis: a two-phase population-based survey1

(2011) F. Guillemin et al.   OSTEOARTHRITIS AND CARTILAGE

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

(2010) C. J. Wruck et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E2 production in osteoarthritic chondrocytes

(2009) Javier Megías et al.   BIOCHEMICAL PHARMACOLOGY

Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression

(2009) James W. Kaspar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation

(2009) Ignazio Barbagallo et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance

(2008) M. Li et al.   DIABETES

Oxidative stress reaction in the meniscus of Bach 1 deficient mice: Potential prevention of meniscal degeneration

(2008) Satoshi Ochiai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus

(2008) Marc Y Donath et al.   Nature clinical practice. Endocrinology & metabolism