Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages

(2014) Finn K. Hansen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Histology, Glycosaminoglycan Level and Cartilage Stiffness in Monoiodoacetate-Induced Osteoarthritis: Comparative Analysis with Anterior Cruciate Ligament Transection in Rat Model and Human Osteoarthritis

(2014) Sangeetha Vasudevaraj Naveen et al.   International Journal of Medical Sciences

Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress

(2014) S.-C. Su et al.   OSTEOARTHRITIS AND CARTILAGE

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage

(2014) Anuranjani et al.   Redox Biology

Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation

(2013) Kirsty L. Culley et al.   ARTHRITIS AND RHEUMATISM

A novel histone deacetylase (HDAC) inhibitor MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells

(2013) Nabanita Patra et al.   BIOMEDICINE & PHARMACOTHERAPY

Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia

(2013) Victoria Clérigues et al.   CLINICAL SCIENCE

Therapeutic Effects of NK-HDAC-1, a Novel Histone Deacetylase Inhibitor, on Collagen-Induced Arthritis Through the Induction of Apoptosis of Fibroblast-Like Synoviocytes

(2013) Minghui Li et al.   INFLAMMATION

HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain

(2013) Stacey Beth Foti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Is osteoarthritis a metabolic disease?

(2013) Jérémie Sellam et al.   JOINT BONE SPINE

Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: An immunohistochemical study

(2013) A. Kaspiris et al.   Orthopaedics & Traumatology-Surgery & Research

The Heme-Heme Oxygenase System in Wound Healing; Implications for Scar Formation

(2012) Frank A.D.T.G. Wagener et al.   CURRENT DRUG TARGETS

Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice

(2012) A. C. Ogbonna et al.   EUROPEAN JOURNAL OF PAIN

Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro

(2012) Liping Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

What constitutes an “animal model of osteoarthritis” – the need for consensus?

(2012) C.B. Little et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice

(2012) S. Hashimoto et al.   OSTEOARTHRITIS AND CARTILAGE

Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate

(2012) Carmen La Porta et al.   PAIN

Measurement of MMP Activity in Synovial Fluid in Cases of Osteoarthritis and Acute Inflammatory Conditions of the Knee Joints Using a Fluorogenic Peptide Probe-Immobilized Diagnostic Kit

(2012) Ju Hee Ryu et al.   Theranostics

Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease

(2011) Nuria Maicas et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts

(2011) Victoria Clérigues et al.   BIOCHEMICAL PHARMACOLOGY

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

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(2011) Leo Joosten et al.   MOLECULAR MEDICINE

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

(2010) C. J. Wruck et al.   ANNALS OF THE RHEUMATIC DISEASES

Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis

(2010) Wei-Ping Chen et al.   MOLECULAR BIOLOGY REPORTS

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence that Cisplatin-induced Auditory Damage is Attenuated by Downregulation of Pro-inflammatory Cytokines Via Nrf2/HO-1

(2008) HongSeob So et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

(2008) Y. Nasu et al.   OSTEOARTHRITIS AND CARTILAGE