Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Serum from humans on long-term calorie restriction enhances stress resistance in cell culture

(2016) Daniela Omodei et al.   Aging-US

Reflections on the Theories of Aging, of Oxidative Stress, and of Science in General. Is It Time to Abandon the Free Radical (Oxidative Stress) Theory of Aging?

(2015) Stefan I. Liochev   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

(2015) Kaitlyn N. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis

(2014) Marianna Sadagurski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

(2014) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Advances in Geroscience: Impact on Healthspan and Chronic Disease

(2014) J. B. Burch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

(2014) Azman Abdullah et al.   Pharmacological Reports

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

(2014) Shu-Feng Zhou et al.   Drug Design Development and Therapy

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

(2013) Eleni N. Tsakiri et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation

(2013) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety

(2013) Robert J. Fox et al.   CURRENT MEDICAL RESEARCH AND OPINION

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

(2013) Eleni N. Tsakiri et al.   FASEB JOURNAL

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

(2012) Michael J. Steinbaugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It

(2012) Kaitlyn N. Lewis et al.   ANTIOXIDANTS & REDOX SIGNALING

Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle

(2012) Corey J. Miller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress

(2012) Danielle J. Reuland et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stress Resistance in the Naked Mole-Rat: The Bare Essentials – A Mini-Review

(2012) Kaitlyn N. Lewis et al.   GERONTOLOGY

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Getting to the Heart of the Matter: Age-related Changes in Diastolic Heart Function in the Longest-lived Rodent, the Naked Mole Rat

(2012) K. M. Grimes et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

(2012) Elise L. Donovan et al.   Oxidative Medicine and Cellular Longevity

Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

(2012) Sellamuthu S. Gounder et al.   PLoS One

Extending healthy ageing: nutrient sensitive pathway and centenarian population

(2012) Sergio Davinelli et al.   Immunity & Ageing

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

(2011) Evi M. Mercken et al.   AGEING RESEARCH REVIEWS

Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity

(2011) Yael H. Edrey et al.   AGING CELL

Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer

(2011) Constance Lay Lay Saw et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

(2011) Vasanthi R. Muthusamy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

(2011) Eun Bae Kim et al.   NATURE

Caloric restriction delays aging-induced cellular phenotypes in rhesus monkey skeletal muscle

(2010) Susan H. McKiernan et al.   EXPERIMENTAL GERONTOLOGY

Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old

(2010) Adeel Safdar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

(2010) K. N. Lewis et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

NRF2, cancer and calorie restriction

(2010) A Martín-Montalvo et al.   ONCOGENE

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice

(2009) S. P. Singh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice

(2009) S. F. Leiser et al.   MOLECULAR AND CELLULAR BIOLOGY

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

(2008) Rochelle Buffenstein   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

(2008) Young-Joon Surh et al.   PLANTA MEDICA

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

(2008) K. J. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiovascular risk factors in centenarians

(2007) Antonio Galioto et al.   EXPERIMENTAL GERONTOLOGY