DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

Exonuclease 1 and its versatile roles in DNA repair

(2016) Guido Keijzers et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

More end resection is not merrier

(2016) Dali Zong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preclinical testing of an ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer

(2016) Katarzyna B. Leszczynska et al.   RADIOTHERAPY AND ONCOLOGY

DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation

(2016) Emil Mladenov et al.   SEMINARS IN CANCER BIOLOGY

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

(2016) Lorenza P. Ferretti et al.   Nature Communications

More end resection is not merrier

(2016) Dali Zong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sumoylation regulates EXO1 stability and processing of DNA damage

(2015) Serena Bologna et al.   CELL CYCLE

Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection

(2015) Balaji Parameswaran et al.   CELL CYCLE

Exonuclease 1-dependent and independent mismatch repair

(2015) Eva M. Goellner et al.   DNA REPAIR

Emerging role of protein phosphatases changes the landscape of phospho-signaling in DNA damage response

(2015) Xiao-Feng Zheng et al.   DNA REPAIR

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

14-3-3 Proteins Restrain the Exo1 Nuclease to Prevent Overresection

(2015) Xiaoqing Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway

(2015) Jenny Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

(2015) Andrew E.H. Elia et al.   MOLECULAR CELL

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

(2015) Ismail Hassan Ismail et al.   NATURE CELL BIOLOGY

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

(2015) Kyriaki Michailidou et al.   NATURE GENETICS

The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response

(2015) Feng Zhang et al.   NUCLEIC ACIDS RESEARCH

Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

(2015) Jessica S. Brown et al.   Cell Reports

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

(2014) Nodar Makharashvili et al.   MOLECULAR CELL

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Proteomic identification of protein ubiquitination events

(2013) Guoqiang Xu et al.   Biotechnology & Genetic Engineering Reviews

Naked Replication Forks Break apRPArt

(2013) Oscar Fernandez-Capetillo et al.   CELL

Regulation of WASH-Dependent Actin Polymerization and Protein Trafficking by Ubiquitination

(2013) Yi-Heng Hao et al.   CELL

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation

(2013) Lisa Postow et al.   CELL CYCLE

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PCNA promotes processive DNA end resection by Exo1

(2013) Xiaoqing Chen et al.   NUCLEIC ACIDS RESEARCH

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

Controlling DNA-end resection: a new task for CDKs

(2013) Lorenza P. Ferretti et al.   Frontiers in Genetics

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

Sumoylation of MDC1 is important for proper DNA damage response

(2012) Kuntian Luo et al.   EMBO JOURNAL

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

(2012) Jacob Falck et al.   EMBO REPORTS

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Ubiquitin and SUMO in DNA repair at a glance

(2012) H. D. Ulrich   JOURNAL OF CELL SCIENCE

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

(2012) Jeffrey Buis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

Single-Nucleotide Polymorphism of the Exo1 Gene: Association with Gastric Cancer Susceptibility and Interaction with Smoking in Taiwan

(2011) Da-Tian Bau   CHINESE JOURNAL OF PHYSIOLOGY

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks

(2011) S. Liao et al.   NUCLEIC ACIDS RESEARCH

SCF ubiquitin ligases in the maintenance of genome stability

(2011) Joshua S. Silverman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors

(2010) B. McEllin et al.   CANCER RESEARCH

DNA end resection by CtIP and exonuclease 1 prevents genomic instability

(2010) Wassim Eid et al.   EMBO REPORTS

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

(2010) Jennifer M. Doyle et al.   MOLECULAR CELL

Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

(2010) Matthew L Nicolette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATR: a master conductor of cellular responses to DNA replication stress

(2010) Rachel Litman Flynn et al.   TRENDS IN BIOCHEMICAL SCIENCES

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

(2009) Jeffrey Hannah et al.   DNA REPAIR

Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

(2009) Travis H. Stracker et al.   DNA REPAIR

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

(2009) Nozomi Tomimatsu et al.   EMBO REPORTS

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Involvement of Exo1b in DNA damage-induced apoptosis

(2009) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

(2009) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan

(2009) Ming-Hsui Tsai et al.   ORAL ONCOLOGY

Pathway Analysis of Single-Nucleotide Polymorphisms Potentially Associated with Glioblastoma Multiforme Susceptibility Using Random Forests

(2008) J. S. Chang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Modulation of the DNA-damage response to HZE particles by shielding

(2008) B MUKHERJEE et al.   DNA REPAIR

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: A case-control analysis

(2008) Guangfu Jin et al.   LUNG CANCER

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

(2008) A. V. Nimonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA