P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland

(2016) Timothy Daniel Kayes et al.   JOURNAL OF IMMUNOLOGY

Sjögren’s syndrome patients with ectopic germinal centers present with a distinct salivary proteome

(2016) Nicolas Delaleu et al.   RHEUMATOLOGY

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

P2X Receptors and Inflammation

(2015) Francesco Virgilio   CURRENT MEDICINAL CHEMISTRY

Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration

(2015) Ellen Witte et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells

(2014) Farid G. El-Sayed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

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Novel aspects of Sjögren’s syndrome in 2012

(2013) Angela Tincani et al.   BMC Medicine

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Sjögren's syndrome and the epithelial target: A comprehensive review

(2013) M.J. Barrera et al.   JOURNAL OF AUTOIMMUNITY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

The P2X7receptor-inflammasome complex has a role in modulating the inflammatory response in primary Sjögren's syndrome

(2013) C. Baldini et al.   JOURNAL OF INTERNAL MEDICINE

Up-regulation and activation of the P2Y2nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons

(2013) Troy S. Peterson et al.   JOURNAL OF NEUROCHEMISTRY

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

(2013) Luiz Alves et al.   MOLECULES

ATP release and purinergic signaling in NLRP3 inflammasome activation

(2013) Aurélie Gombault et al.   Frontiers in Immunology

P2X7 receptor activation induces inflammatory responses in salivary gland epithelium

(2012) Lucas T. Woods et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Synergy between adiponectin and interleukin-1β on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes

(2012) Yeon-Ah Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Purinergic P2Y2 Receptors Promote Neutrophil Infiltration and Hepatocyte Death in Mice With Acute Liver Injury

(2012) Cemil Korcan Ayata et al.   GASTROENTEROLOGY

P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis

(2012) Simona Deplano et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Mitochondria: commanders of innate immunity and disease?

(2011) Suzanne M Cloonan et al.   CURRENT OPINION IN IMMUNOLOGY

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Activation of P2X7R and downstream effects in bleomycin treated lung epithelial cells

(2011) Robert Bläsche et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

(2011) Ravi S. Akundi et al.   PLoS One

Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration

(2010) Annabelle Cesaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2X7Receptor Signaling in the Pathogenesis of Smoke-Induced Lung Inflammation and Emphysema

(2010) Monica Lucattelli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Potential Role for P2X7R in Allergic Airway Inflammation in Mice and Humans

(2010) Tobias Müller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cytokines in Sjogren's syndrome: potential therapeutic targets

(2010) N. Roescher et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

(2010) G. Lopez-Castejon et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Pain and purinergic signaling

(2009) Makoto Tsuda et al.   BRAIN RESEARCH REVIEWS

Efficiency of T-cell costimulation by CD80 and CD86 cross-linking correlates with calcium entry

(2009) Markus Thiel et al.   IMMUNOLOGY

P2Y2 Receptor Transcription Is Increased by NF- B and Stimulates Cyclooxygenase-2 Expression and PGE2 Released by Intestinal Epithelial Cells

(2009) E. Degagne et al.   JOURNAL OF IMMUNOLOGY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis

(2009) S. R.J. Taylor et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

P2X7 Receptor-mediated Membrane Blebbing in Salivary Epithelial Cells

(2009) Sung-Min Hwang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

Sepsis induces brain mitochondrial dysfunction

(2008) Joana da Costa P. d’Avila et al.   CRITICAL CARE MEDICINE

Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells

(2008) Shinji Shimoda et al.   HEPATOLOGY

Purinergic P2X7Receptors Mediate ATP-induced Saliva Secretion by the Mouse Submandibular Gland

(2008) Tetsuji Nakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecular-1 expression and enhances lymphocyte adherence to a human submandibular gland cell line

(2007) Olga J. Baker et al.   MOLECULAR IMMUNOLOGY