Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

The IL-1 Family Member 7b Translocates to the Nucleus and Down-Regulates Proinflammatory Cytokines

(2014) S. Sharma et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1  Released from Dying Cells

(2014) T. Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammation

(2010) Leo A. B. Joosten   ARTHRITIS AND RHEUMATISM

How interleukin-1β induces gouty arthritis

(2010) Charles A. Dinarello   ARTHRITIS AND RHEUMATISM

Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study

(2010) Alexander So et al.   ARTHRITIS AND RHEUMATISM

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Why not treat human cancer with interleukin-1 blockade?

(2010) Charles A. Dinarello   CANCER AND METASTASIS REVIEWS

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1

(2010) F. L. van de Veerdonk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Blockade of interleukin 1 in type 1 diabetes mellitus

(2010) Thomas Mandrup-Poulsen et al.   Nature Reviews Endocrinology

Update on gout: new therapeutic strategies and options

(2010) Robert Terkeltaub   Nature Reviews Rheumatology

The Effect of the Interleukin-1 Cytokine Family Members IL-1F6 and IL-1F8 on Adipocyte Differentiation

(2010) Edwin J.P. van Asseldonk et al.   Obesity

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1  secretion

(2010) S. Tassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1

(2009) Dirk E. Smith et al.   IMMUNITY

Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In Vivo

(2009) Nelson C. Di Paolo et al.   IMMUNITY

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

(2009) Yeonseok Chung et al.   IMMUNITY

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Autoinflammation: The prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses

(2009) Raphaela Goldbach-Mansky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1β

(2009) Miyako Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resident Dendritic Cells Prevent Postischemic Acute Renal Failure by Help of Single Ig IL-1 Receptor-Related Protein

(2009) M. Lech et al.   JOURNAL OF IMMUNOLOGY

The Role of Macrophage-Derived IL-1 in Induction and Maintenance of Angiogenesis

(2009) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response

(2009) K. Bulek et al.   JOURNAL OF IMMUNOLOGY

Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component

(2009) John A. Lust et al.   MAYO CLINIC PROCEEDINGS

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Autoinflammatory Disease Due to Homozygous Deletion of theIL1RNLocus

(2009) Sreelatha Reddy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intravitreal Anakinra Inhibits Choroidal Neovascular Membrane Growth in a Rat Model

(2009) Jeffrey L. Olson et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Alternate Splicing of Interleukin-1 Receptor Type II (IL1R2) In Vitro Correlates with Clinical Glucocorticoid Responsiveness in Patients with AIED

(2009) Andrea Vambutas et al.   PLoS One

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization

(2009) Cecilia Garlanda et al.   TRENDS IN IMMUNOLOGY

Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice

(2008) Marije I. Koenders et al.   ARTHRITIS AND RHEUMATISM

The pattern of response to anti–interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis

(2008) Marco Gattorno et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: Results from two sequential placebo-controlled studies

(2008) Hal M. Hoffman et al.   ARTHRITIS AND RHEUMATISM

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION

Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women

(2008) D. S. Hittel et al.   DIABETES

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain

(2007) Ali Akoum et al.   FERTILITY AND STERILITY

IL-1β secretion induced by Aggregatibacter (Actinobacillus) actinomycetemcomitans is mainly caused by the leukotoxin

(2007) Peyman Kelk et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY