In vitrocytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

(2017) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin-Modifying Agents Increase Transcription of CYP46A1, a Key Player in Brain Cholesterol Elimination

(2017) Inês Milagre et al.   JOURNAL OF ALZHEIMERS DISEASE

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

(2016) Kyle W. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices

(2016) Min-Yu Sun et al.   JOURNAL OF NEUROPHYSIOLOGY

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel

(2015) Christine M Emnett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

(2015) Farah Chali et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

(2015) Min-Yu Sun et al.   NEUROSCIENTIST

Different oxysterols have opposing actions at N-methyl-d-aspartate receptors

(2014) Andrew J. Linsenbardt et al.   NEUROPHARMACOLOGY

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Cholesterol loss during glutamate-mediated excitotoxicity

(2012) Alejandro O Sodero et al.   EMBO JOURNAL

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression ofCYP46A1gene transcription

(2010) Maria João Nunes et al.   JOURNAL OF NEUROCHEMISTRY

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Intercellular Glutamate Signaling in the Nervous System and Beyond

(2009) David E. Featherstone   ACS Chemical Neuroscience

Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase

(2009) Natalia Mast et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

(2009) Marjan Shafaati et al.   JOURNAL OF LIPID RESEARCH

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

(2008) Mark Andrew White et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors

(2008) Marjan Shafaati et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Transcriptional regulation of the humanCYP46A1brain-specific expression by Sp transcription factors

(2008) Ins Milagre et al.   JOURNAL OF NEUROCHEMISTRY

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

(2008) T. Kotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA