Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Central Nervous System Penetration of Antiretroviral Drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic Considerations

(2015) Eric H. Decloedt et al.   CLINICAL PHARMACOKINETICS

Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus

(2015) Farah Chali et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival

(2015) Min-Yu Sun et al.   NEUROSCIENTIST

Type 1 and Type 2 scenarios in hydrogen exchange mass spectrometry studies on protein–ligand complexes

(2014) Lars Konermann et al.   ANALYST

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

(2011) C. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methods for the analysis of high precision differential hydrogen–deuterium exchange data

(2010) Michael J. Chalmers et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Cytochrome P450 7A1 Cholesterol 7α-Hydroxylation

(2010) Raku Shinkyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase

(2009) Natalia Mast et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

(2009) Marjan Shafaati et al.   JOURNAL OF LIPID RESEARCH

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

(2008) Mark Andrew White et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA