Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors

Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse

(2017) Chuanqing Wu et al.   HUMAN MOLECULAR GENETICS

Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46

(2017) Michael Taschner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

(2017) Hemant B. Badgandi et al.   JOURNAL OF CELL BIOLOGY

RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly

(2017) Yuya Nishijima et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors

(2017) Tomoaki Hirano et al.   MOLECULAR BIOLOGY OF THE CELL

Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46–IFT56 as well as on its nuclear localization signal

(2017) Teruki Funabashi et al.   MOLECULAR BIOLOGY OF THE CELL

Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system

(2017) Yohei Katoh et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule Motors Drive Hedgehog Signaling in Primary Cilia

(2017) Mu He et al.   TRENDS IN CELL BIOLOGY

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex

(2016) Michael Taschner et al.   EMBO JOURNAL

Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins

(2016) Niedharsan Pooranachandran et al.   GENETICS

Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex

(2016) Yohei Katoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E

(2016) Shohei Nozaki et al.   JOURNAL OF CELL SCIENCE

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin

(2016) Tomohiro Kubo et al.   JOURNAL OF CELL SCIENCE

Two classes of short intraflagellar transport train with different 3D structures are present inChlamydomonasflagella

(2016) Elisa Vannuccini et al.   JOURNAL OF CELL SCIENCE

Microtubule doublets are double-track railways for intraflagellar transport trains

(2016) L. Stepanek et al.   SCIENCE

The Intraflagellar Transport Machinery

(2016) Michael Taschner et al.   Cold Spring Harbor Perspectives in Biology

Ciliopathies

(2016) Daniela A. Braun et al.   Cold Spring Harbor Perspectives in Biology

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

(2016) Karsten Boldt et al.   Nature Communications

Role for the IFT-A Complex in Selective Transport to the Primary Cilium

(2016) Wenxiang Fu et al.   Cell Reports

Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins

(2016) Niedharsan Pooranachandran et al.   GENETICS

The essential roles of transition fibers in the context of cilia

(2015) Qing Wei et al.   CURRENT OPINION IN CELL BIOLOGY

Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism

(2015) Julie M. Craft et al.   JOURNAL OF CELL BIOLOGY

Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins

(2015) Y. Katoh et al.   JOURNAL OF CELL SCIENCE

Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia

(2015) Bram Prevo et al.   NATURE CELL BIOLOGY

IFT–Cargo Interactions and Protein Transport in Cilia

(2015) Karl F. Lechtreck   TRENDS IN BIOCHEMICAL SCIENCES

Cilia and Diseases

(2014) Jason M. Brown et al.   BIOSCIENCE

The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3

(2014) Gerald M. Liew et al.   DEVELOPMENTAL CELL

IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment

(2014) Thibaut Eguether et al.   DEVELOPMENTAL CELL

Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly

(2014) Michael Taschner et al.   JOURNAL OF CELL BIOLOGY

Subunit composition of the human cytoplasmic dynein-2 complex

(2014) D. Asante et al.   JOURNAL OF CELL SCIENCE

The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment

(2014) Mu He et al.   NATURE CELL BIOLOGY

The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling

(2014) Y. C. Liu et al.   Science Signaling

G-protein-coupled receptors, Hedgehog signaling and primary cilia

(2014) Saikat Mukhopadhyay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

(2014) Corey L. Williams et al.   Nature Communications

A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling

(2014) Ruth E. Swiderski et al.   PLoS Genetics

Kinesin-2: A Family of Heterotrimeric and Homodimeric Motors with Diverse Intracellular Transport Functions

(2013) Jonathan M. Scholey   Annual Review of Cell and Developmental Biology

Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo

(2013) Yanick Botilde et al.   DEVELOPMENTAL BIOLOGY

The roles of evolutionarily conserved functional modules in cilia-related trafficking

(2013) Ching-Hwa Sung et al.   NATURE CELL BIOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

(2013) S. Bhogaraju et al.   SCIENCE

IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport

(2012) Brian T. Keady et al.   DEVELOPMENTAL CELL

Intrinsic Protein-Protein Interaction-mediated and Chaperonin-assisted Sequential Assembly of Stable Bardet-Biedl Syndrome Protein Complex, the BBSome

(2012) Qihong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinesin-2 family in vertebrate ciliogenesis

(2012) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation

(2011) Nicolas F. Berbari et al.   DEVELOPMENTAL BIOLOGY

Crystal structure of the intraflagellar transport complex 25/27

(2011) Sagar Bhogaraju et al.   EMBO JOURNAL

Subunit Interactions and Organization of theChlamydomonas reinhardtiiIntraflagellar Transport Complex A Proteins

(2011) Robert H. Behal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Mapping of Interactions within the Intraflagellar Transport (IFT) B Core Complex

(2011) Michael Taschner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments

(2011) Limin Hao et al.   NATURE CELL BIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Motor KIF17 Is Fundamental for Memory and Learning via Differential Support of Synaptic NR2A/2B Levels

(2011) Xiling Yin et al.   NEURON

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

(2010) Hua Jin et al.   CELL

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Direct Interactions of Intraflagellar Transport Complex B Proteins IFT88, IFT52, and IFT46

(2010) Ben F. Lucker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chlamydomonas IFT70/CrDYF-1 Is a Core Component of IFT Particle Complex B and Is Required for Flagellar Assembly

(2010) Zhen-Chuan Fan et al.   MOLECULAR BIOLOGY OF THE CELL

Different roles for KIF17 and kinesin II in photoreceptor development and maintenance

(2009) Christine Insinna et al.   DEVELOPMENTAL DYNAMICS

Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas

(2009) Zhaohui Wang et al.   PLoS One

Characterization of mouse IFT complex B

(2009) John A. Follit et al.   CELL MOTILITY AND THE CYTOSKELETON

The homodimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development

(2008) Christine Insinna et al.   DEVELOPMENTAL BIOLOGY

A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation

(2008) Alexander V. Loktev et al.   DEVELOPMENTAL CELL

ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery

(2008) Noveera T. Ahmed et al.   JOURNAL OF CELL BIOLOGY

Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease

(2008) Julie A. Jonassen et al.   JOURNAL OF CELL BIOLOGY

elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

(2008) Yoshihiro Omori et al.   NATURE CELL BIOLOGY

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

(2008) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA