Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex

(2016) Michael Taschner et al.   EMBO JOURNAL

Autophagosome–lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

(2016) Junya Hasegawa et al.   EMBO JOURNAL

Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex

(2016) Yohei Katoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity

(2016) Eyad Kalawy Fansa et al.   Nature Communications

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

(2016) Karsten Boldt et al.   Nature Communications

Advances in Skeletal Dysplasia Genetics

(2015) Krista A. Geister et al.   Annual Review of Genomics and Human Genetics

The essential roles of transition fibers in the context of cilia

(2015) Qing Wei et al.   CURRENT OPINION IN CELL BIOLOGY

A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation

(2015) Hao Lu et al.   DEVELOPMENTAL BIOLOGY

A Phosphoinositide Code for Primary Cilia

(2015) Fubito Nakatsu   DEVELOPMENTAL CELL

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins

(2015) Y. Katoh et al.   JOURNAL OF CELL SCIENCE

MKS1 regulates ciliary INPP5E levels in Joubert syndrome

(2015) Gisela G Slaats et al.   JOURNAL OF MEDICAL GENETICS

A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

(2015) Katja Gotthardt et al.   eLife

Unmasking the ciliopathies: craniofacial defects and the primary cilium

(2015) Claudio R. Cortés et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Cilia and Diseases

(2014) Jason M. Brown et al.   BIOSCIENCE

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly

(2014) Michael Taschner et al.   JOURNAL OF CELL BIOLOGY

Ciliopathies: The Trafficking Connection

(2014) Kayalvizhi Madhivanan et al.   TRAFFIC

Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering

(2014) Yukiko Kimura et al.   Scientific Reports

The nphp-2 and arl-13 Genetic Modules Interact to Regulate Ciliogenesis and Ciliary Microtubule Patterning in C. elegans

(2014) Simon R. F. Warburton-Pitt et al.   PLoS Genetics

A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling

(2014) Ruth E. Swiderski et al.   PLoS Genetics

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

(2014) Hiroaki Ishikawa et al.   eLife

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Joubert syndrome: congenital cerebellar ataxia with the molar tooth

(2013) Marta Romani et al.   LANCET NEUROLOGY

The roles of evolutionarily conserved functional modules in cilia-related trafficking

(2013) Ching-Hwa Sung et al.   NATURE CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81

(2013) S. Bhogaraju et al.   SCIENCE

Active Transport and Diffusion Barriers Restrict Joubert Syndrome-Associated ARL13B/ARL-13 to an Inv-like Ciliary Membrane Subdomain

(2013) Sebiha Cevik et al.   PLoS Genetics

Arl13b in Primary Cilia Regulates the Migration and Placement of Interneurons in the Developing Cerebral Cortex

(2012) Holden Higginbotham et al.   DEVELOPMENTAL CELL

Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies

(2012) Sarah E. Conduit et al.   FEBS LETTERS

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking

(2012) Karel F. Liem et al.   JOURNAL OF CELL BIOLOGY

Rab11 regulates exocytosis of recycling vesicles at the plasma membrane

(2012) Senye Takahashi et al.   JOURNAL OF CELL SCIENCE

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rabs and other small GTPases in ciliary transport

(2011) Yi Shan Lim et al.   BIOLOGY OF THE CELL

Architecture and function of IFT complex proteins in ciliogenesis

(2011) Michael Taschner et al.   DIFFERENTIATION

Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/arfophilin-1 localization in mitotic cells

(2011) Senye Takahashi et al.   GENES TO CELLS

Localization of retinitis pigmentosa 2 to cilia is regulated by Importin  2

(2011) T. W. Hurd et al.   JOURNAL OF CELL SCIENCE

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins

(2011) Christine E. Larkins et al.   MOLECULAR BIOLOGY OF THE CELL

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

(2011) Ben Chih et al.   NATURE CELL BIOLOGY

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo

(2011) Shehab A Ismail et al.   Nature Chemical Biology

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

(2011) Francesc R Garcia-Gonzalo et al.   NATURE GENETICS

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small GTPases and cilia

(2011) Yujie Li et al.   Protein & Cell

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP

(2010) John F. Dishinger et al.   NATURE CELL BIOLOGY

Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion

(2009) N. A. Duldulao et al.   DEVELOPMENT

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

(2009) Sébastien Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome

(2008) Vincent Cantagrel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation

(2008) Yuji Hori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease

(2008) Julie A. Jonassen et al.   JOURNAL OF CELL BIOLOGY