Review
Immunology
Naoya Tatsumi, Yosuke Kumamoto
Summary: Conventional dendritic cells (cDCs) are a powerful type of antigen-presenting cells, consisting of different subsets with distinct developmental, phenotypic, and functional characteristics. After immunization, each subset of cDCs acquires antigens in the secondary lymphoid organs and presents them to CD4T cells in a spatiotemporal manner, resulting in multiple waves of antigen presentation. This review focuses on the kinetics of antigen presentation by each cDC subset and its impact on priming naive CD4T cells, as well as its implications in CD4T cell differentiation.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Immunology
Sookjin Moon, Yunji Park, Sumin Hyeon, Young-Min Kim, Ji-Hae Kim, Hyekang Kim, Subin Park, Kun-Joo Lee, Bon-Kyoung Koo, Sang-Jun Ha, Seung-Woo Lee
Summary: This study reveals that intestinal epithelial cells express MHC II and PD-L1 in the distal small intestine, inducing the transformation of CD4(+) cells into CD4(+)CD8 alpha alpha(+) IELs. PD-1 signals support the acquisition of CD8 alpha alpha by down-regulating the CD4-lineage transcription factor, ThPOK, through the SHP pathway, providing niche adaptation signals for tissue-resident CD4(+)CD8 alpha alpha(+) IELs.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Oscar J. Cordero, Carlos Rafael-Vidal, Ruben Varela-Calvino, Cristina Calvino-Sampedro, Beatriz Malvar-Fernandez, Samuel Garcia, Juan E. Vinuela, Jose M. Pego-Reigosa
Summary: Immune system CD4 T-cells with high cell-surface CD26 expression demonstrate anti-tumoral properties, especially when engineered with a chimeric antigen receptor. Different T helper cell subsets show variations in CD26 expression levels, which could impact research on CAR-T cells. The relationship between glycoprotein sCD26 and its enzymatic activity, as well as its correlation with specific T cell subsets, still requires further understanding.
Article
Multidisciplinary Sciences
Jiqin Zhang, Yongxian Hu, Jiaxuan Yang, Wei Li, Mingming Zhang, Qingcan Wang, Linjie Zhang, Guoqing Wei, Yue Tian, Kui Zhao, Ang Chen, Binghe Tan, Jiazhen Cui, Deqi Li, Yi Li, Yalei Qi, Dongrui Wang, Yuxuan Wu, Dali Li, Bing Du, Mingyao Liu, He Huang
Summary: A two-in-one approach to generate non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9 was successfully developed, demonstrating feasibility and efficacy in a preclinical study. An innovative type of anti-CD19 CAR-T cell with PD1 integration showed superior ability to eradicate tumor cells.
Article
Oncology
Karen Kai-Lin Fang, Jongbok Lee, Ismat Khatri, Yoosu Na, Li Zhang
Summary: The use of allogeneic CAR4-DNTs as adoptive cell therapy for T-cell malignancies is effective. CAR4-DNTs can effectively target T-ALL and PTCL and have superior cytotoxicity compared to empty-vector transduced DNTs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Guilherme Piovezani Ramos, Adebowale O. Bamidele, Emily E. Klatt, Mary R. Sagstetter, Ahmed T. Kurdi, Feda H. Hamdan, Robyn Laura Kosinsky, Joseph M. Gaballa, Asha Nair, Zhifu Sun, Surendra Dasari, Ian R. Lanza, Cody N. Rozeveld, Micah B. Schott, Guillermo Urrutia, Maria S. Westphal, Benjamin D. Clarkson, Charles L. Howe, Eric V. Marietta, David H. Luckey, Joseph A. Murray, Michelle Gonzalez, Manuel B. Braga Neto, Hunter R. Gibbons, Thomas C. Smyrk, Steven Johnsen, Gwen Lomberk, William A. Faubion
Summary: Inhibition of G9a enzyme promotes the development of regulatory T cells (Tregs) in human CD4 T cells, suggesting the potential use of G9a inhibitors for the treatment of immune-mediated diseases.
Article
Biochemistry & Molecular Biology
Christiane Majer, Holger Lingel, Aditya Arra, Hans-Gert Heuft, Dirk Bretschneider, Silke Balk, Katrin Vogel, Monika C. Brunner-Weinzierl
Summary: Newborn CD4 T-cells show activation-induced events and produce Th1 cytokines in response to Staphylococcus aureus, indicating their ability to mount immediate and controlled antibacterial responses. The proliferation of neonatal T-helper cells is influenced by sex, IL-2 receptor expression, and the PD-1/PD-L1 axis. In addition, the regulation of multifunctional T-helper cells is exclusively mediated by the PD-1/PD-L1 axis in neonatal CD4 T-cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Mark S. Lee, Peter J. Tuohy, Caleb Y. Kim, Katrina Lichauco, Heather L. Parrish, Koenraad Van Doorslaer, Michael S. Kuhns, Richard N. McLaughlin
Summary: Through evolution, purifying selection has shaped motifs in the CD4 protein that enhance its response to MHCII molecules. The importance of CD4-Lck interactions is derived from the balancing activity of an inhibitory motif, as well as motifs that direct CD4-Lck pairs to specific membrane compartments.
Review
Immunology
Jarrod York, Kavitha Gowrishankar, Kenneth Micklethwaite, Sarah Palmer, Anthony L. Cunningham, Najla Nasr
Summary: Despite the effectiveness of ART in reducing morbidity and mortality associated with HIV infection, the latent HIV reservoir remains a major barrier to immune clearance and HIV cure. CAR T cell therapies, involving genetically engineered T cells, offer promising potential in targeting HIV-infected cells and have shown efficacy, safety, and long-term persistence in peripheral blood.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Martin Somoza, Adriano Bertelli, Cecilia A. Pratto, Ramiro E. Verdun, Oscar Campetella, Juan Mucci
Summary: Trypanosoma cruzi infection induces a polyclonal B cell proliferative response that regulates CD4(+) T cell immune responses by inducing apoptosis, arresting cell division, and affecting the development of proinflammatory response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Veronica L. Nagle, Charli Ann J. Hertz, Kelly E. Henry, Maya S. Graham, Carl Campos, Nagavarakishore Pillarsetty, Andrea Schietinger, Ingo K. Mellinghoff, Jason S. Lewis
Summary: This study explores the use of anti-human-CD4 minibody for antibody-based PET to visualize human CD4(+) T cells. Through in vitro and in vivo experiments, it is found that this method can accurately detect CD4(+) T cells without impacting their abundance, proliferation, and activation state. In humanized mice, this method can also visualize the distribution of CD4(+) T cells in peripheral tissues and brain tumors.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Immunology
Di Wang, Yu Jiang, Yangzi Song, Yongqin Zeng, Cuilin Li, Xinyue Wang, Ying Liu, Jiang Xiao, Yaxian Kong, Hongxin Zhao
Summary: The study revealed that CD4(+) T cells in PLHIV exhibited enhanced secretion of proinflammatory cytokines and polyfunctionality due to HIV disease progression, while altered T-cell subsets led to discordant results in total and CD4(+) T-cell subsets.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Vita Golubovskaya, Hua Zhou, Feng Li, Michael Valentine, Jinying Sun, Robert Berahovich, Shirley Xu, Milton Quintanilla, Man Cheong Ma, John Sienkiewicz, Yanwei Huang, Lijun Wu
Summary: CAR-T cell therapy, specifically targeting CD19, has been approved by the FDA for leukemia and lymphoma treatment. This study introduces novel CD37 and CD37-CD19 CAR-T cells, demonstrating their specific targeting abilities and laying the foundation for future clinical studies.
Review
Immunology
Remi Fromentin, Nicolas Chomont
Summary: The HIV reservoir is not homogenous and is composed of multiple cell types with distinct biological properties. These cells contribute to HIV persistence through specific mechanisms.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Immunology
Naoki Kaneko, Julie Boucau, Hsiao-Hsuan Kuo, Cory Perugino, Vinay S. Mahajan, Jocelyn R. Farmer, Hang Liu, Thomas J. Diefenbach, Alicja Piechocka-Trocha, Kristina Lefteri, Michael T. Waring, Katherine R. Premo, Bruce D. Walker, Jonathan Z. Li, Gaurav Gaiha, Xu G. Yu, Mathias Lichterfeld, Robert F. Padera, Shiv Pillai
Summary: The study found that cytotoxic CD4+ T cells increase in the lungs, draining lymph nodes, and blood in severe COVID-19, while CD8+ T cells do not show a significant increase. This suggests that CD4+ T cells may play a role in viral clearance and contribute to lung inflammation and fibrosis in severe COVID-19.
CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
John Reiser, Kavitha Sadashivaiah, Aki Furusawa, Arnob Banerjee, Nevil Singh
CELLULAR IMMUNOLOGY
(2019)
Article
Immunology
Kenneth M. Rosenberg, Nevil J. Singh
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Immunology
Marina Cella, Ramya Gamini, Cristiane Secca, Patrick L. Collins, Shanrong Zhao, Vincent Peng, Michelle L. Robinette, Jorge Schettini, Konstantin Zaitsev, William Gordon, Jennifer K. Bando, Kentaro Yomogida, Victor Cortez, Catrina Fronick, Robert Fulton, Lih-Ling Lin, Susan Gilfillan, Richard A. Flavell, Liang Shan, Maxim N. Artyomov, Michael Bowman, Eugene M. Oltz, Scott A. Jelinsky, Marco Colonna
Article
Immunology
Jennifer K. Bando, Susan Gilfillan, Blanda Di Luccia, Jose L. Fachi, Cristiane Secca, Marina Cella, Marco Colonna
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Immunology
Qianli Wang, Michelle L. Robinette, Cyrielle Billon, Patrick L. Collins, Jennifer K. Bando, Jose Luis Fachi, Cristiane Secca, Sofia I. Porter, Ankita Saini, Susan Gilfillan, Laura A. Solt, Erik S. Musiek, Eugene M. Oltz, Thomas P. Burris, Marco Colonna
SCIENCE IMMUNOLOGY
(2019)
Article
Immunology
Daniel DiToro, Stacey N. Harbour, Jennifer K. Bando, Gloria Benavides, Steven Witte, Vincent A. Laufer, Carson Moseley, Jeffery R. Singer, Blake Frey, Henrietta Turner, Jens Bruning, Victor Darley-Usmar, Min Gao, Cheryl Conover, Robin D. Hatton, Stuart Frank, Marco Colonna, Casey T. Weaver
Article
Multidisciplinary Sciences
Susannah C. Shissler, Nevil J. Singh, Tonya J. Webb
SCIENTIFIC REPORTS
(2020)
Review
Biochemistry & Molecular Biology
Courtney A. Matson, Nevil J. Singh
MOLECULAR IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Courtney A. Matson, Seeyoung Choi, Ferenc Livak, Bin Zhao, Apratim Mitra, Paul E. Love, Nevil J. Singh
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Immunology
Zvi Grossman, Nevil J. Singh, Francesco R. Simonetti, Michael M. Lederman, Daniel C. Douek, Steven G. Deeks
TRENDS IN IMMUNOLOGY
(2020)
Editorial Material
Immunology
Jennifer K. Bando, Marco Colonna
TRENDS IN IMMUNOLOGY
(2020)
Article
Cell Biology
Brock G. Bennion, Carys A. Croft, Teresa L. Ai, Wei Qian, Amber M. Menos, Cathrine A. Miner, Marie-Louis Fremond, Jean-Marc Doisne, Prabhakar S. Andhey, Derek J. Platt, Jennifer K. Bando, Erin R. Wang, Hella Luksch, Thierry J. Molina, Elisha D. O. Roberson, Maxim N. Artyomov, Angela Roesen-Wolff, Marco Colonna, Frederic Rieux-Laucat, James P. Di Santo, Benedicte Neven, Jonathan J. Miner
Article
Multidisciplinary Sciences
Cristiane Secca, Jennifer K. Bando, Jose L. Fachi, Susan Gilfillan, Vincent Peng, Blanda Di Luccia, Marina Cella, Keely G. McDonald, Rodney D. Newberry, Marco Colonna
Summary: LTi-like cells play a crucial role in maintaining gut epithelial integrity and protection against bacterial infections. The retention of LTi-like cells in conventional solitary intestinal lymphoid tissue is controlled by the chemokine receptor CXCR5. Deletion of Cxcr5 leads to uncontrolled activity of LTi-like cells and increased IL-22 production, improving gut barrier integrity in mice infected with Clostridium difficile.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Simone Brioschi, Wei-Le Wang, Vincent Peng, Meng Wang, Irina Shchukina, Zev J. Greenberg, Jennifer K. Bando, Natalia Jaeger, Rafael S. Czepielewski, Amanda Swain, Denis A. Mogilenko, Wandy L. Beatty, Peter Bayguinov, James A. J. Fitzpatrick, Laura G. Schuettpelz, Catrina C. Fronick, Igor Smirnov, Jonathan Kipnis, Virginia S. Shapiro, Gregory F. Wu, Susan Gilfillan, Marina Cella, Maxim N. Artyomov, Steven H. Kleinstein, Marco Colonna
Summary: The meninges contain adaptive immune cells called B cells that are thought to originate locally from the calvaria, providing a constant supply of CNS-educated B cells. Additionally, a subset of antigen-experienced B cells in the meninges of aging mice are found to be blood-borne, suggesting a potential mechanism for maintaining immune privilege within the CNS.
Article
Oncology
Sara Fioretti, Courtney A. Matson, Kenneth M. Rosenberg, Nevil J. Singh
Summary: Research shows that under CAR-T cell immunotherapy, normal B cells can downregulate the expression of CD19 to evade attack, and this downregulation is reversible. This finding is significant for improving immunotherapy and minimizing B cell depletion during treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)