标题
TLR agonists: our best frenemy
in cancer immunotherapy
作者
关键词
-
出版物
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 93, Issue 6, Pages 847-863
出版商
Wiley
发表日期
2013-03-09
DOI
10.1189/jlb.1012501
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- MyD88 Plays a Critical T Cell-Intrinsic Role in Supporting CD8 T Cell Expansion during Acute Lymphocytic Choriomeningitis Virus Infection
- (2014) A. H. Rahman et al. JOURNAL OF IMMUNOLOGY
- Activated Human Neonatal CD8+ T Cells Are Subject to Immunomodulation by Direct TLR2 or TLR5 Stimulation
- (2014) M. McCarron et al. JOURNAL OF IMMUNOLOGY
- SNAPIN: an endogenous toll-like receptor ligand in rheumatoid arthritis
- (2012) Bo Shi et al. ANNALS OF THE RHEUMATIC DISEASES
- Augmentation of Therapeutic Responses in Melanoma by Inhibition of IRAK-1,-4
- (2012) R. Srivastava et al. CANCER RESEARCH
- dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8
- (2012) Y Estornes et al. CELL DEATH AND DIFFERENTIATION
- Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer
- (2012) S. Adams et al. CLINICAL CANCER RESEARCH
- The application of Toll like receptors for cancer therapy
- (2012) Eui Young So et al. International Journal of Biological Sciences
- Reduced expression of Toll-like receptor 4 inhibits human breast cancer cells proliferation and inflammatory cytokines secretion
- (2012) Huan Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Anticancer TLR agonists on the ropes
- (2012) Malini Guha NATURE REVIEWS DRUG DISCOVERY
- Structure of the activating IL-1 receptor signaling complex
- (2012) Christoph Thomas et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Gene Silencing of Toll-Like Receptor 2 Inhibits Proliferation of Human Liver Cancer Cells and Secretion of Inflammatory Cytokines
- (2012) Yuzheng Huang et al. PLoS One
- MMP-13 Regulates Growth of Wound Granulation Tissue and Modulates Gene Expression Signatures Involved in Inflammation, Proteolysis, and Cell Viability
- (2012) Mervi Toriseva et al. PLoS One
- Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation
- (2012) J. M. Reynolds et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CpG ODN107 potentiates radiosensitivity of human glioma cells via TLR9-mediated NF-κB activation and NO production
- (2012) Xiaoli Li et al. TUMOR BIOLOGY
- Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses
- (2012) Francesc Rudilla et al. VACCINE
- Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells
- (2012) Wen-Xia Kuai WORLD JOURNAL OF GASTROENTEROLOGY
- Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer
- (2012) Wagner J Fávaro et al. Infectious Agents and Cancer
- Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer
- (2011) O A Khan et al. BRITISH JOURNAL OF CANCER
- Anticancer function of polyinosinic-polycytidylic acid
- (2011) Yu-sheng Cheng et al. CANCER BIOLOGY & THERAPY
- Genetic Variants of Toll-Like Receptor 2 and 5, Helicobacter Pylori Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population
- (2011) H.-M. Zeng et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists
- (2011) P L Triozzi et al. CANCER GENE THERAPY
- Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth
- (2011) Z. Cai et al. CANCER RESEARCH
- Gender-Specific Cytokine Pathways, Targets, and Biomarkers for the Switch from Health to Adenoma and Colorectal Cancer
- (2011) Patrizia Pellegrini et al. Clinical & Developmental Immunology
- Intratumoral Administration of TLR4 Agonist Absorbed into a Cellular Vector Improves Antitumor Responses
- (2011) M. B. Davis et al. CLINICAL CANCER RESEARCH
- High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4
- (2011) Xiao-Mei Zhu et al. CYTOKINE
- Effects of Toll-like receptor signals in T-cell neoplasms
- (2011) Cori Morrison et al. Future Oncology
- Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk
- (2011) Anton G. Kutikhin HUMAN IMMUNOLOGY
- Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses
- (2011) Mohamed Labib Salem IMMUNOLOGY LETTERS
- Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10
- (2011) M. Mellett et al. JOURNAL OF IMMUNOLOGY
- TLR1/TLR2 Agonist Induces Tumor Regression by Reciprocal Modulation of Effector and Regulatory T Cells
- (2011) Y. Zhang et al. JOURNAL OF IMMUNOLOGY
- Toll-Like Receptors in Normal and Malignant Human Bladders
- (2011) Cherifa Ayari et al. JOURNAL OF UROLOGY
- Novel regulatory mechanism and functional implication of plasminogen activator inhibitor-1 (PAI-1) expression in CpG-ODN-stimulated macrophages
- (2011) Bikash Thapa et al. MOLECULAR IMMUNOLOGY
- Engineering Dendritic Cells to Enhance Cancer Immunotherapy
- (2011) Jeanette E Boudreau et al. MOLECULAR THERAPY
- Increased Expression of Toll-like Receptors (TLR) 2, 4 and 5 in Gastric Dysplasia
- (2011) Pedro Pimentel-Nunes et al. PATHOLOGY & ONCOLOGY RESEARCH
- Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-α
- (2011) Suneesh Kumar Pachathundikandi et al. PLoS One
- Induction of human β-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-κB, and AP-1
- (2010) Stefanie Scharf et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- When Toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effector function
- (2010) D. Geng et al. BLOOD
- TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients
- (2010) Chao Wang et al. BMC CANCER
- Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells
- (2010) Yue Wang et al. CANCER LETTERS
- Amplifying TLR-MyD88 Signals within Tumor-Specific T Cells Enhances Antitumor Activity to Suboptimal Levels of Weakly Immunogenic Tumor Antigens
- (2010) D. Geng et al. CANCER RESEARCH
- Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma
- (2010) C. Brignole et al. CANCER RESEARCH
- Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands
- (2010) R. Conforti et al. CANCER RESEARCH
- TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis
- (2010) Manabu Taura et al. CANCER SCIENCE
- Polysaccharide Krestin Is a Novel TLR2 Agonist that Mediates Inhibition of Tumor Growth via Stimulation of CD8 T Cells and NK Cells
- (2010) H. Lu et al. CLINICAL CANCER RESEARCH
- TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
- (2010) Deepak Mittal et al. EMBO JOURNAL
- Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease
- (2010) Joseph M. Reynolds et al. IMMUNITY
- Mycobacterium tuberculosisLipoproteins Directly Regulate Human Memory CD4+T Cell Activation via Toll-Like Receptors 1 and 2
- (2010) Christina L. Lancioni et al. INFECTION AND IMMUNITY
- Reactive Oxygen Species Enhance TLR10 Expression in the Human Monocytic Cell Line THP-1
- (2010) Donghee Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Transactivation of the Epidermal Growth Factor Receptor by Heat Shock Protein 90 via Toll-like Receptor 4 Contributes to the Migration of Glioblastoma Cells
- (2010) Dominique Thuringer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus
- (2010) Zhongcheng Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
- (2010) José M. González-Navajas et al. JOURNAL OF CLINICAL INVESTIGATION
- Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs
- (2010) Yenkel Grinberg-Bleyer et al. JOURNAL OF CLINICAL INVESTIGATION
- Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice
- (2010) Qing Zhu et al. JOURNAL OF CLINICAL INVESTIGATION
- Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
- (2010) Julien Cherfils-Vicini et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase III Randomized Trial Assessing Rofecoxib in the Adjuvant Setting of Colorectal Cancer: Final Results of the VICTOR Trial
- (2010) Rachel S. Midgley et al. JOURNAL OF CLINICAL ONCOLOGY
- In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study
- (2010) Joshua D. Brody et al. JOURNAL OF CLINICAL ONCOLOGY
- Dual Stimulation of MyD88‐Dependent Toll‐Like Receptors Induces Synergistically Enhanced Production of Inflammatory Cytokines in Murine Bone Marrow–Derived Dendritic Cells
- (2010) Daniel Mitchell et al. JOURNAL OF INFECTIOUS DISEASES
- The biological paths of IL-1 family members IL-18 and IL-33
- (2010) Dirk E. Smith JOURNAL OF LEUKOCYTE BIOLOGY
- Structure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif Is Required for Recognition by Toll-Like Receptor 11
- (2010) Kaury Kucera et al. JOURNAL OF MOLECULAR BIOLOGY
- Oncogenically active MYD88 mutations in human lymphoma
- (2010) Vu N. Ngo et al. NATURE
- Targeting Toll-like receptors: emerging therapeutics?
- (2010) Elizabeth J. Hennessy et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular Modeling-Based Evaluation of hTLR10 and Identification of Potential Ligands in Toll-Like Receptor Signaling
- (2010) Rajiv Gandhi Govindaraj et al. PLoS One
- Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees
- (2009) B. Varghese et al. BLOOD
- Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion
- (2009) R. Houot et al. BLOOD
- Toll-like Receptors 3 and 7 Agonists Enhance Tumor Cell Lysis by Human T Cells
- (2009) H. Shojaei et al. CANCER RESEARCH
- Direct recognition of LPS by human but not murine CD8+T cellsviaTLR4 complex
- (2009) Mousa Komai‐Koma et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The contribution of direct TLR signaling to T cell responses
- (2009) Adeeb H. Rahman et al. IMMUNOLOGIC RESEARCH
- Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas
- (2009) Camilla Rydberg et al. IMMUNOLOGY
- Toll-like receptor agonists in cancer therapy
- (2009) Sylvia Adams Immunotherapy
- T-cell intrinsic expression of MyD88 is required for sustained expansion of the virus-specific CD8+ T-cell population in LCMV-infected mice
- (2009) C. Bartholdy et al. JOURNAL OF GENERAL VIROLOGY
- Locally Administered TLR7 Agonists Drive Systemic Antitumor Immune Responses That Are Enhanced by Anti-CD40 Immunotherapy
- (2009) S. A. Broomfield et al. JOURNAL OF IMMUNOLOGY
- The Adaptor Molecule MyD88 Directly Promotes CD8 T Cell Responses to Vaccinia Virus
- (2009) Yuan Zhao et al. JOURNAL OF IMMUNOLOGY
- TLR2 Engagement on CD8 T Cells Enables Generation of Functional Memory Cells in Response to a Suboptimal TCR Signal
- (2009) B. C. Mercier et al. JOURNAL OF IMMUNOLOGY
- TLR3 Ligand Induces NF- B Activation and Various Fates of Multiple Myeloma Cells Depending on IFN- Production
- (2009) D. Chiron et al. JOURNAL OF IMMUNOLOGY
- Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
- (2009) Kim Midwood et al. NATURE MEDICINE
- Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma
- (2009) Geoffrey W. Stone et al. PLoS One
- Role of toll-like receptors in tissue repair and tumorigenesis
- (2008) S. Rakoff-Nahoum et al. BIOCHEMISTRY-MOSCOW
- A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
- (2008) M. Quigley et al. BLOOD
- Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines
- (2008) Tanja D. de Gruijl et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide
- (2008) Guangwen Ren et al. Cell Stem Cell
- Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells
- (2008) K. Chochi et al. CLINICAL CANCER RESEARCH
- Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity
- (2008) Nicole Asprodites et al. FASEB JOURNAL
- Toll-Like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer
- (2008) Sang Hoon Rhee et al. GASTROENTEROLOGY
- Toll‐like receptors and adaptor molecules in liver disease: Update
- (2008) Ekihiro Seki et al. HEPATOLOGY
- Randomized Phase II Trial of a Toll-Like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination With First-Line Taxane Plus Platinum Chemotherapy for Advanced-Stage Non–Small-Cell Lung Cancer
- (2008) Christian Manegold et al. JOURNAL OF CLINICAL ONCOLOGY
- Role of Toll-like receptors in gastrointestinal malignancies
- (2008) M Fukata et al. ONCOGENE
- Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines
- (2008) Q. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- T cell expression of MyD88 is required for resistance to Toxoplasma gondii
- (2008) D. F. LaRosa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice
- (2008) Mohamed L. Salem et al. VACCINE
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