Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson’s Disease Models

Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death

(2016) Tian-Ya Liu et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

(2016) Yanwei Li et al.   NEUROPHARMACOLOGY

Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity

(2016) Shuai Zhang et al.   NEUROTOXICOLOGY

Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation

(2015) Jun Hu et al.   INFLAMMATION

Interleukin-10 Protection against Lipopolysaccharide-Induced Neuro-Inflammation and Neurotoxicity in Ventral Mesencephalic Cultures

(2015) Yan Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

(2015) Shou-Peng Fu et al.   Journal of Neuroinflammation

Enriched rat primary ventral mesencephalic neurons as an in-vitro culture model

(2015) Venkata S. Bollimpelli et al.   NEUROREPORT

Lico A Enhances Nrf2-Mediated Defense Mechanisms againstt-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells

(2015) Hongming Lv et al.   Oxidative Medicine and Cellular Longevity

Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells

(2015) J Guadagno et al.   Cell Death & Disease

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells

(2015) Jen-Pi Tsai et al.   Oncotarget

Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways

(2015) Wenjin Hao et al.   Scientific Reports

Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation

(2015) Jie Liu et al.   Scientific Reports

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Microglial regulation of immunological and neuroprotective functions of astroglia

(2014) Shih-Heng Chen et al.   GLIA

BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF-κB Activation

(2014) Shou-Peng Fu et al.   MEDIATORS OF INFLAMMATION

Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/IKK/NF-κB, MAPKs and Akt signaling pathways

(2014) Xiaoxiao Wang et al.   NEUROPHARMACOLOGY

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

(2014) J. P. L. Daher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass

(2014) Leiguo Ming et al.   Scientific Reports

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

(2013) Vanesa Sanchez-Guajardo et al.   ASN Neuro

Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice

(2013) Michael D. Burton et al.   BRAIN BEHAVIOR AND IMMUNITY

Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A

(2013) Xiao Chu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

Licochalcone A Inhibits Lipopolysaccharide-Induced Inflammatory Response in Vitro and in Vivo

(2012) Xiao Chu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection

(2012) Sang Keun Ha et al.   NEUROPHARMACOLOGY

Establishment of a Survival and Toxic Cellular Model for Parkinson’s Disease from Chicken Mesencephalon

(2012) Amparo Tolosa et al.   NEUROTOXICITY RESEARCH

Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity

(2012) Pradeep Dewapriya et al.   NEUROTOXICOLOGY

Rhynchophylline Attenuates LPS-induced Pro-inflammatory Responses through Down-regulation of MAPK/NF-κB Signaling Pathways in Primary Microglia

(2012) Yu Song et al.   PHYTOTHERAPY RESEARCH

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson’s disease

(2011) In-Su Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

(2011) Hye Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

The RGD-containing peptide fragment of osteopontin protects tyrosine hydroxylase positive cells against toxic insult in primary ventral mesencephalic cultures and in the rat substantia nigra

(2010) Joanna Iczkiewicz et al.   JOURNAL OF NEUROCHEMISTRY

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation

(2008) Megumi Funakoshi-Tago et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES-1 and COX-2

(2008) Antonio Carlos Pinheiro de Oliveira et al.   GLIA

Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

(2008) Hyuck-Se Kwon et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

(2008) María del Carmen Hernández-Romero et al.   JOURNAL OF NEUROCHEMISTRY

Microglial responses to dopamine in a cell culture model of Parkinson's disease

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Neurobiology and treatment of Parkinson's disease

(2008) Anthony H.V. Schapira   TRENDS IN PHARMACOLOGICAL SCIENCES

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY