Article
Plant Sciences
Siti Zaidathul Iman Zolkiffly, Johnson Stanslas, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat
Summary: The study aimed to determine the inhibitory properties of Ficus deltoidea Jack aqueous extract on pro-inflammatory mediators in LPS-induced microglial cells. The extract was found to be non-cytotoxic and significantly reduced the levels of reactive oxygen species, nitric oxide, TNF-alpha, IL-1 beta and IL-6 in microglial cells induced by LPS, showing neuroprotective effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Thomas J. LaRocca, Alyssa N. Cavalier, Christine M. Roberts, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Christopher D. Link
Summary: The amyloid beta (A beta) peptide is believed to have a central role in Alzheimer's disease by synergistically promoting pro-inflammatory activation in primary human astrocytes with known cytokines. By directly substituting for the complement component C1q in a cytokine cocktail, A beta activates astrocytes similarly to neurotoxic astrocytes found in brain aging and AD. The biological action of A beta at low concentrations is distinct from that of high doses typically used in in vitro studies.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Jogender Mehla, Itender Singh, Deepti Diwan, James W. Nelson, Molly Lawrence, Eunjae Lee, Adam Q. Bauer, David M. Holtzman, Gregory J. Zipfel
Summary: Inhibition of STAT3 improved cognitive functions, cerebrovascular function, and amyloid pathology while reducing oxidative stress and neuroinflammation, potentially through reducing APP processing and attenuating LRP-1 oxidative modification. These findings highlight the therapeutic potential of STAT3 specific inhibition for the treatment of Alzheimer's disease and cerebral amyloid angiopathy.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xia Zhao, Jinfeng Sun, Li Xiong, Lingyu She, Liwei Li, Hao Tang, Yuqing Zeng, Fan Chen, Xue Han, Shiju Ye, Wei Wang, Xu Wang, Guang Liang
Summary: Dectin-1, a pattern recognition receptor, is involved in microglia-mediated neuroinflammation and the development of Alzheimer's disease (AD). It directly binds to beta-amyloid (Aβ), activating downstream signaling pathways and inducing the expression of inflammatory factors and AD pathology.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Manoj Kumar Pandey
Summary: Lysosomal storage diseases are rare genetic disorders caused by gene defects leading to the accumulation of toxic substances in the lysosome. This study provides an overview of the genetic defects associated with these diseases and their impact on neuro-immune inflammation.
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Bosong Zhang, Yufang Zhao, Kai Guo, Hui Tian, Cao Wang, Ruiqi Wang, Yue Chen, Xiongbiao Chen, Hongxia Zheng, Bingxin Gao, Jieyi Shen, Weiming Tian
Summary: Prevention and early intervention are crucial in treating Alzheimer's disease (AD). This study investigates the use of nanoparticles composed of resveratrol and oligomeric proanthocyanidin grafted with hyaluronic acid to address the issue of ROS accumulation in early AD. The results demonstrate that these nanoparticles are effective in scavenging ROS, reducing brain inflammation, and improving cognitive function in AD mice.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Su-Mei Luo, Long-Yan Li, Li-Zhe Guo, Lu Wang, Yan-Feng Wang, Na Chen, E. Wang
Summary: This study found that dexmedetomidine has a positive effect on inflammation and cognitive function in a mouse model of AD. It alleviates cognitive decline, inhibits neuroinflammation, and prevents the deposition of Abeta. These effects are mediated by the alpha 2 adrenoceptor-mediated anti-inflammatory pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Plant Sciences
Dusadee Ospondpant, Yingjie Xia, Queenie Wing Sze Lai, Gary Ka-Wing Yuen, Meixia Yang, Kanlayakorn Chanthanam, Tina Tingxia Dong, Karl Wah Keung Tsim
Summary: This study evaluated the anti-neuroinflammatory activities of D. cochinchinensis stemwood extract in activated microglia. The results showed that the extract suppressed neuroinflammatory response, increased the expression of anti-inflammatory biomarker Arg1, and modulated excessive phagocytosis. These findings suggested that D. cochinchinensis extract could be a promising natural product for the treatment of neuroinflammatory and neurodegenerative diseases, like AD.
Review
Biochemistry & Molecular Biology
Yi Wang, Kaiyue Wang, Junyuan Yan, Qian Zhou, Xiaoying Wang
Summary: Alzheimer's disease is an incurable type of dementia in the elderly, and our understanding of its etiology and pathogenesis is limited. However, several hypotheses related to risk factors have been proposed, and plant-derived dietary polyphenols have been shown to have protective effects against neurodegenerative diseases. This review summarizes the regulatory effects of these polyphenols on AD-related molecular mechanisms and discusses the issue of bioavailability and potential improvements, aiming to encourage further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Shiting Weng, Qi-Lun Lai, Junjun Wang, Liying Zhuang, Lin Cheng, Yejia Mo, Lu Liu, Zexian Zhao, Ying Zhang, Song Qiao
Summary: Alzheimer's disease is a neurodegenerative disease characterized by progressive dementia. In addition to the accumulation of specific proteins and phosphorylation of tau protein, neuroinflammation and the role of exosomes have also been shown to play a crucial role in the pathogenesis of the disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Tongfei Shi, Jingtong Zhao, Kongrong Long, Mohan Gao, Fangman Chen, Xuenian Chen, Yue Zhang, Baoding Huang, Dan Shao, Chao Yang, Liang Wang, Ming Zhang, Kam W. Leong, Li Chen, Kan He
Summary: The MSN-PEI nanoparticles prepared in this study have potential therapeutic effects in the treatment of osteoarthritis. By targeting multiple danger mediators, they can attenuate cartilage degradation and inflammation, providing strong joint protection.
Article
Neurosciences
Philip Regan, Katriona L. Hole, Julia Sero, Robert J. Williams
Summary: Microglia play a crucial role in late-onset Alzheimer's disease, and flavanol 3-ols have the potential to modulate microglial responsiveness and be used therapeutically.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Developmental Biology
Karina Geurtzen, Alejandra Cristina Lopez-Delgado, Ankita Duseja, Anastasia Kurzyukova, Franziska Knopf
Summary: In zebrafish, a model organism, immune cell behavior during bone repair after osteoblast loss has been studied. Osteoblast loss triggers recruitment of neutrophils and macrophages, which leads to the generation of osteoclasts. Glucocorticoid signaling inhibits macrophage recruitment and changes their phenotype. Although osteoblast loss can be compensated for by committed osteoblasts, macrophages continue to populate the region.
Review
Medicine, Research & Experimental
Samir Kumar Beura, Rishika Dhapola, Abhishek Ramachandra Panigrahi, Pooja Yadav, Dibbanti Harikrishna Reddy, Sunil Kumar Singh
Summary: Alzheimer's disease, a common neurodegenerative disorder, is associated with platelet hyperactivity and ROS generation, which may contribute to disease progression.
Review
Biochemistry & Molecular Biology
James B. McAlpine, Shao-Nong Chen, Andrei Kutateladze, John B. MacMillan, Giovanni Appendino, Andersson Barison, Mehdi A. Beniddir, Maique W. Biavatti, Stefan Bluml, Asmaa Boufridi, Mark S. Butler, Robert J. Capon, Young H. Choi, David Coppage, Phillip Crews, Michael T. Crimmins, Marie Csete, Pradeep Dewapriya, Joseph M. Egan, Mary J. Garson, Gregory Genta-Jouve, William H. Gerwick, Harald Gross, Mary Kay Harper, Precilia Hermanto, James M. Hook, Luke Hunter, Damien Jeannerat, Nai-Yun Ji, Tyler A. Johnson, David G. I. Kingston, Hiroyuki Koshino, Hsiau-Wei Lee, Guy Lewin, Jie Li, Roger G. Linington, Miaomiao Liu, Kerry L. McPhail, Tadeusz F. Molinski, Bradley S. Moore, Joo-Won Nam, Ram P. Neupane, Matthias Niemitz, Jean-Marc Nuzillard, Nicholas H. Oberlies, Fernanda M. M. Ocampos, Guohui Pan, Ronald J. Quinn, D. Sai Reddy, Jean-Hugues Renault, Jose Rivera-Chavez, Wolfgang Robien, Carla M. Saunders, Thomas J. Schmidt, Christoph Seger, Ben Shen, Christoph Steinbeck, Hermann Stuppner, Sonja Sturm, Orazio Taglialatela-Scafati, Dean J. Tantillo, Robert Verpoorte, Bin-Gui Wang, Craig M. Williams, Philip G. Williams, Julien Wist, Jian-Min Yue, Chen Zhang, Zhengren Xu, Charlotte Simmler, David C. Lankin, Jonathan Bisson, Guido F. Pauli
NATURAL PRODUCT REPORTS
(2019)
Article
Plant Sciences
Wei-Hua Jiao, Pradeep Dewapriya, Osama Mohamed, Zeinab G. Khalil, Angela A. Salim, Hou-Wen Lin, Robert J. Capon
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Plant Sciences
Wei-Hua Jiao, Angela A. Salim, Zeinab G. Khalil, Pradeep Dewapriya, Hou-Wen Lin, Mark S. Butler, Robert J. Capon
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Chemistry, Medicinal
Bicheng Fan, Pradeep Dewapriya, Fengjie Li, Martina Bluemel, Deniz Tasdemir
Article
Chemistry, Medicinal
Bicheng Fan, Pradeep Dewapriya, Fengjie Li, Laura Grauso, Martina Bluemel, Alfonso Mangoni, Deniz Tasdemir
Review
Chemistry, Analytical
Bastian Schulze, Youngjoon Jeon, Sarit Kaserzon, Amy L. Heffernan, Pradeep Dewapriya, Jake O'Brien, Maria Jose Gomez Ramos, Sara Ghorbani Gorji, Jochen F. Mueller, Kevin V. Thomas, Saer Samanipour
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Qiuda Zheng, Pradeep Dewapriya, Geoff Eaglesham, Tim Reeks, Jack Thompson, Fahad Ahmed, Pritesh Prasad, Kevin Thomas, Jochen F. Mueller, Phong K. Thai
Summary: The increasing prevalence of gout and diabetes globally has resulted in a higher usage of allopurinol and metformin medications. These medications are excreted as oxypurinol and metformin through urine and are released into wastewater and the environment. The current methods for monitoring the presence of these chemicals in the environment are labor-intensive and potentially inefficient. This study presents a sensitive and simple method using direct-injection LC-MS/MS for the simultaneous measurement of oxypurinol and metformin in wastewater.
DRUG TESTING AND ANALYSIS
(2022)
Article
Engineering, Environmental
Joseph A. Charbonnet, Carrie A. McDonough, Feng Xiao, Trever Schwichtenberg, Dunping Cao, Sarit Kaserzon, Kevin Thomas, Pradeep Dewapriya, Benjamin J. Place, Emma L. Schymanski, Jennifer A. Field, Damian E. Helbling, Christopher P. Higgins
Summary: This article introduces a confidence scale and identification criteria specific to the suspect or nontarget HRMS analysis of PFASs, which helps clarify the level of certainty in PFAS identification and improve the efficiency of identification.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Xiao Tan, Pradeep Dewapriya, Pritesh Prasad, Yixin Chang, Xumin Huang, Yiqing Wang, Xiaokai Gong, Timothy E. Hopkins, Changkui Fu, Kevin Thomas, Hui Peng, Andrew K. Whittaker, Cheng Zhang
Summary: Efficient removal of PFAS from contaminated waters is achieved using novel magnetic fluorinated polymer sorbents, which also provide fast magnetic recovery of the sorbed material. The sorbent demonstrates superior PFAS removal efficiency compared to commercially available activated carbon and ion-exchange resins, and it can be regenerated robustly and efficiently.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Environmental Sciences
Pradeep Dewapriya, Nikolaos Rousis, Cassandra Rauert, Nikolaos S. Thomaidis, Kevin V. Thomas
Summary: Urban stormwater runoff is a major source of water pollution caused by a large mixture of chemicals. The pollutant profile of stormwater samples collected from an Australian creek was analyzed using high-resolution mass spectrometry and chemometric tools. The study identified compounds such as nonpolymeric surfactants, plastic additives, rubber and resin-related products, and natural products in the stormwater. The prioritization workflow used in this study proved to be an effective tool for assessing key stormwater-related compounds and determining their environmental effects.
Article
Engineering, Environmental
Pradeep Dewapriya, Sandra Nilsson, Sara Ghorbani Gorji, Jake W. O'Brien, Jennifer Braunig, Maria Jose Gomez Ramos, Eric Donaldson, Saer Samanipour, Jonathan W. Martin, Jochen F. Mueller, Sarit L. Kaserzon, Kevin V. Thomas
Summary: Leaching of PFASs from Australian firefighting training grounds has resulted in extensive contamination. A study identified various PFAS classes in cattle's blood exposed to contaminated groundwater and discovered novel PFASs. Results suggest that targeting only major PFASs underestimates the toxicological risks associated with exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Mathieu Feraud, Jake W. O'Brien, Saer Samanipour, Pradeep Dewapriya, Denice van Herwerden, Sarit Kaserzon, Ian Wood, Cassandra Rauert, Kevin V. Thomas
Summary: Non-target analysis (NTA) using high-resolution mass spectrometry (HRMS) coupled with liquid chromatography is increasingly employed for identifying biologically relevant chemicals. Interpreting HRMS datasets, which are often recorded in vendor-specific formats, can be challenging due to their large and complex nature. InSpectra is a web-based, open-source platform that offers flexible and extensible NTA workflows for the systematic detection of emerging chemical threats. It provides a reproducible and transparent approach for identifying, tracking, and prioritizing these threats.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Medicinal
Angela A. Salim, Waleed M. Hussein, Pradeep Dewapriya, Huy N. Hoang, Yahao Zhou, Kaumadi Samarasekera, Zeinab G. Khalil, David P. Fairlie, Robert J. Capon
Summary: The application of a miniaturized 24-well plate system allowed for the optimization of cultivation conditions for the marine-derived fungus Talaromyces sp. CMB-TU011, leading to the discovery of a rare cycloheptapeptide talarolide A and three new analogues. Detailed spectroscopic analysis, supported by Marfey's analysis methodology, helped confirm the structures of these compounds. The investigation of hydroxamates' influence on cyclic peptide conformation through ROESY correlations and solution structure determination offers insights into the potential use of hydroxamates as molecular bridges for accessing new cyclic peptide conformations.
Article
Engineering, Environmental
Pradeep Dewapriya, Lachlan Chadwick, Sara Ghorbani Gorji, Bastian Schulze, Sara Valsecchi, Saer Samanipour, Kevin V. Thomas, Sarit L. Kaserzon
Summary: Although the sources of per- and polyfluoroalkyl substances (PFAS) are known, their use in consumer household products is not well-studied. This study analyzed literature from the past decade to provide a comprehensive analysis of the types and concentrations of PFAS in consumer products. The results showed that there are various PFAS present in consumer products, with the highest concentrations found in household firefighting products, textile finishing agents, and household chemicals. The study also identified fluorotelomer alcohol, polyfluoroalkyl phosphate esters, perfluorocarboxylic acid, and perfluorosulfonic acid as the classes of PFAS of high interest. However, there are knowledge gaps that need further research, such as developing analytical methods, method validation and quality assurance/quality control approaches, suspect and non-target analysis, and understanding human exposure risk.
JOURNAL OF HAZARDOUS MATERIALS LETTERS
(2023)
Correction
Biochemistry & Molecular Biology
James B. McAlpine, Shao-Nong Chen, Andrei Kutateladze, John B. MacMillan, Giovanni Appendino, Andersson Barison, Mehdi A. Beniddir, Maique W. Biavatti, Stefan Bluml, Asmaa Boufridi, Mark S. Butler, Robert J. Capon, Young H. Choi, David Coppage, Phillip Crews, Michael T. Crimmins, Marie Csete, Pradeep Dewapriya, Joseph M. Egan, Mary J. Garson, Gregory Genta-Jouve, William H. Gerwick, Harald Gross, Mary Kay Harper, Precilia Hermanto, James M. Hook, Luke Hunter, Damien Jeannerat, Nai-Yun Ji, Tyler A. Johnson, David G. I. Kingston, Hiroyuki Koshino, Hsiau-Wei Lee, Guy Lewin, Jie Li, Roger G. Linington, Miaomiao Liu, Kerry L. McPhail, Tadeusz F. Molinski, Bradley S. Moore, Joo-Won Nam, Ram P. Neupane, Matthias Niemitz, Jean-Marc Nuzillard, Nicholas H. Oberlies, Fernanda M. M. Ocampos, Guohui Pan, Ronald J. Quinn, D. Sai Reddy, Jean-Hugues Renault, Jose Rivera-Chavez, Wolfgang Robien, Carla M. Saunders, Thomas J. Schmidt, Christoph Seger, Ben Shen, Christoph Steinbeck, Hermann Stuppner, Sonja Sturm, Orazio Taglialatela-Scafati, Dean J. Tantillo, Robert Verpoorte, Bin-Gui Wang, Craig M. Williams, Philip G. Williams, Julien Wist, Jian-Min Yue, Chen Zhang, Zhengren Xu, Charlotte Simmler, David C. Lankin, Jonathan Bisson, Guido F. Pauli
NATURAL PRODUCT REPORTS
(2019)