Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils

(2017) H. Wilms et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Cytokine Gene Polymorphisms and Parkinson's Disease: A Meta-Analysis

(2014) Chu Ketan et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Inflammatory cytokines and NT-proCNP in Parkinson’s disease patients

(2012) Dariusz Koziorowski et al.   CYTOKINE

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2Production in Astrocytes

(2012) Miriam Font-Nieves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease

(2012) Valerio Pisani et al.   Journal of Neuroinflammation

Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates

(2012) P. Barkholt et al.   NEUROSCIENCE

Interleukin-10 promoter polymorphisms in Chinese patients with Parkinson's disease

(2012) Dequan Li et al.   NEUROSCIENCE LETTERS

Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor

(2012) Mahmoud M. Iravani et al.   NEUROSCIENCE LETTERS

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

Diagnosis of Parkinson's Disease Based on Disease-Specific Autoantibody Profiles in Human Sera

(2012) Min Han et al.   PLoS One

Non-Motor Symptoms in Patients with Parkinson’s Disease – Correlations with Inflammatory Cytokines in Serum

(2012) Daniel Lindqvist et al.   PLoS One

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Toxin Models of Mitochondrial Dysfunction in Parkinson's Disease

(2011) Terina N. Martinez et al.   ANTIOXIDANTS & REDOX SIGNALING

Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice

(2011) Masatoshi Inden et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

GDNF fails to exert neuroprotection in a rat  -synuclein model of Parkinson's disease

(2011) M. Decressac et al.   BRAIN

Administration of LPS-Stimulated Autologous Macrophages Induces α-Synuclein Aggregation in Dopaminergic Neurons of Rat Brain

(2011) T. N. Sergeyeva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

A deadly spread: cellular mechanisms of α-synuclein transfer

(2011) J A Steiner et al.   CELL DEATH AND DIFFERENTIATION

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impaired CD200–CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK

(2011) Xi-Jin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcription factor p53 influences microglial activation phenotype

(2011) Suman Jayadev et al.   GLIA

E46K Human α-Synuclein Transgenic Mice Develop Lewy-like and Tau Pathology Associated with Age-dependent, Detrimental Motor Impairment

(2011) Kristel L. Emmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

(2011) M. Mizutani et al.   JOURNAL OF IMMUNOLOGY

Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease

(2011) Candan Depboylu et al.   JOURNAL OF NEUROIMMUNOLOGY

Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains

(2011) Zhiren Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

(2011) Lalida Rojanathammanee et al.   Journal of Neuroinflammation

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Possible Involvement of Complement Factor C1q in the Clearance of Extracellular Neuromelanin From the Substantia Nigra in Parkinson Disease

(2011) Candan Depboylu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

MPP+-induced toxicity in the presence of dopamine is mediated by COX-2 through oxidative stress

(2011) Ya-Ching Hsieh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Lack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro

(2011) Susan A. Austin et al.   NEUROCHEMICAL RESEARCH

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Immunization strategies for Parkinson's disease

(2011) Duy Ha et al.   PARKINSONISM & RELATED DISORDERS

Cell-to-Cell Interactions and Signals Involved in the Reconstitution of Peripheral CD8+ TCM and TEM Cell Pools

(2011) Bruno Zaragoza et al.   PLoS One

BCG Vaccine-Induced Neuroprotection in a Mouse Model of Parkinson's Disease

(2011) Jing Yong et al.   PLoS One

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and sporadic Parkinson’s disease in an Italian cohort

(2010) E. Pascale et al.   ACTA NEUROLOGICA SCANDINAVICA

Relationship between inflammatory reaction and ischemic injury of caudate-putamen in rats: inflammatory reaction and brain ischemia

(2010) Shuhua Mu et al.   ANATOMICAL SCIENCE INTERNATIONAL

An interlocked oscillator model for firing of the mesencephalic dopaminergic neuron.

(2010) Joon Ha et al.   BMC NEUROSCIENCE

Effects of Hydrogen Sulfide-releasing l-DOPA Derivatives on Glial Activation

(2010) Moonhee Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Activated microglial cells acquire an immature dendritic cell phenotype and may terminate the immune response in an acute model of EAE

(2010) Beatriz Almolda et al.   JOURNAL OF NEUROIMMUNOLOGY

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Apoptosis of peripheral blood lymphocytes in Parkinson patients

(2010) Màtil Calopa et al.   NEUROBIOLOGY OF DISEASE

Molecular Profiling of a 6-Hydroxydopamine Model of Parkinson’s Disease

(2010) Sang J. Na et al.   NEUROCHEMICAL RESEARCH

The roles of TNF in brain dysfunction and disease

(2010) Ian A. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats

(2010) Zhongwang Yu et al.   PLoS One

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

(2010) Cintia Roodveldt et al.   PLoS One

Defining “Neuroinflammation”

(2009) James P. O'Callaghan et al.   Annals of the New York Academy of Sciences

Identification of the amino acid sequence motif of α-synuclein responsible for macrophage activation

(2009) Saet-byul Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NSAID Use and the Risk of Parkinsonʼs Disease

(2009) Ali Samii et al.   DRUGS & AGING

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

α-Synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP

(2009) Seonghan Kim et al.   JOURNAL OF NEUROCHEMISTRY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson’s Disease

(2009) Jae-Kyung Lee et al.   Journal of Neuroimmune Pharmacology

Association of α-Synuclein Immunoreactivity With Inflammatory Activity in Multiple Sclerosis Lesions

(2009) Jian-Qiang Lu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Acute and Chronic 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administrations Elicit Similar Microglial Activation in the Substantia Nigra of Monkeys

(2009) Marianne Vázquez-Claverie et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Kinetics of Microglial Activation and Degeneration of Dopamine-Containing Neurons in a Rat Model of Parkinson Disease Induced by 6-Hydroxydopamine

(2009) Vincent Henry et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV  -Synucleinopathy

(2009) C. Y. Chung et al.   JOURNAL OF NEUROSCIENCE

In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury

(2009) Tony Frugier et al.   JOURNAL OF NEUROTRAUMA

Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells

(2009) Ashley D. Reynolds et al.   JOURNAL OF PROTEOME RESEARCH

The role of α-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response

(2009) Mikhail Y. Golovko et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of chronic low dose rotenone treatment on human microglial cells

(2009) Shamim B Shaikh et al.   Molecular Neurodegeneration

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release

(2009) Heather Klintworth et al.   NEUROSCIENCE LETTERS

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytokines disrupt intracellular patterns of Parkinson's disease-associated proteins alpha-synuclein, tau and ubiquitin in cultured glial cells

(2008) Roger J. Bick et al.   BRAIN RESEARCH

Levodopa therapy reduces DNA damage in peripheral blood cells of patients with Parkinson’s disease

(2008) T. Cornetta et al.   CELL BIOLOGY AND TOXICOLOGY

Inflammation-related genes and the risk of Parkinson’s disease: a multilocus approach

(2008) J. Infante et al.   EUROPEAN JOURNAL OF NEUROLOGY

Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease

(2008) Ji-Young Park et al.   GLIA

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study

(2008) Mahyar Etminan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Nitrated Alpha-Synuclein and Microglial Neuroregulatory Activities

(2008) Ashley D. Reynolds et al.   Journal of Neuroimmune Pharmacology

The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains

(2008) Y YASUDA et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuron-microglia signaling: Chemokines as versatile messengers

(2008) K. Biber et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

(2008) James B Koprich et al.   Journal of Neuroinflammation

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats

(2008) Melissa K McCoy et al.   MOLECULAR THERAPY

Oxidative and Inflammatory Pathways in Parkinson’s Disease

(2008) Rebecca L. Miller et al.   NEUROCHEMICAL RESEARCH

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

Interleukin-10 (IL10) and tumor necrosis factor α (TNF) gene polymorphisms in Parkinson's disease patients

(2008) M. Bialecka et al.   PARKINSONISM & RELATED DISORDERS

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Encapsulated cell biodelivery of GDNF: A novel clinical strategy for neuroprotection and neuroregeneration in Parkinson's disease?

(2007) Olle Lindvall et al.   EXPERIMENTAL NEUROLOGY

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING

Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

(2003) Thomas Dehmer et al.   JOURNAL OF NEUROCHEMISTRY