Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells

Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer

(2020) Satoshi Endo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells

(2019) Satoshi Endo et al.   NUTRITION RESEARCH

CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver

(2018) Adolfo Quiñones Lombraña et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes

(2018) Woo-In Ryu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2 cells

(2017) HyunA Jo et al.   FOOD AND CHEMICAL TOXICOLOGY

Human Tissue Distribution of Carbonyl Reductase 1 Using Proteomic Approach With Liquid Chromatography-Tandem Mass Spectrometry

(2017) Wenyi Hua et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state

(2017) Angela A.M. Kämpfer et al.   TOXICOLOGY IN VITRO

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells

(2016) Naoko Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors

(2015) Koji Takeuchi et al.   DIGESTION

Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1

(2015) Dawei Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

TNF-α Modulation of Intestinal Epithelial Tight Junction Barrier Is Regulated by ERK1/2 Activation of Elk-1

(2013) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional bowel symptoms in quiescent inflammatory bowel diseases: role of epithelial barrier disruption and low-grade inflammation

(2013) M Vivinus-Nébot et al.   GUT

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Myosin light chain kinase: pulling the strings of epithelial tight junction function

(2012) Kevin E. Cunningham et al.   Annals of the New York Academy of Sciences

Expression profiling of claudins in the human gastrointestinal tract in health and during inflammatory bowel disease

(2012) Anke L. Lameris et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Prostaglandin E2 Produced by Entamoeba histolytica Signals via EP4 Receptor and Alters Claudin-4 to Increase Ion Permeability of Tight Junctions

(2011) Manigandan Lejeune et al.   AMERICAN JOURNAL OF PATHOLOGY

ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers

(2011) G. Samak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human Carbonyl Reductases

(2011) Petra Malatkova et al.   CURRENT DRUG METABOLISM

Increase in the Tight Junction Protein Claudin-1 in Intestinal Inflammation

(2011) Lisa S. Poritz et al.   DIGESTIVE DISEASES AND SCIENCES

The role of TNF-α signaling pathway on COX-2 upregulation and cognitive decline induced by β-amyloid peptide

(2010) Rodrigo Medeiros et al.   BEHAVIOURAL BRAIN RESEARCH

Prevention of Traditional NSAID-Induced Small Intestinal Injury: Recent Preliminary Studies Using Capsule Endoscopy

(2010) Shunji Fujimori et al.   DIGESTION

Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine

(2010) Atsushi Tamura et al.   GASTROENTEROLOGY

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Claudin-2, a component of the tight junction, forms a paracellular water channel

(2010) R. Rosenthal et al.   JOURNAL OF CELL SCIENCE

Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization

(2010) J. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin E2-EP1 and EP2 receptor signaling promotes apical junctional complex disassembly of Caco-2 human colorectal cancer cells

(2009) Marcelo N Tanaka et al.   BMC CELL BIOLOGY

Two Nonsynonymous Single Nucleotide Polymorphisms of Human Carbonyl Reductase 1 Demonstrate Reduced in Vitro Metabolism of Daunorubicin and Doxorubicin

(2009) O. S. Bains et al.   DRUG METABOLISM AND DISPOSITION

Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7

(2008) Tadayuki Oshima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Changes in the expression of claudins in active ulcerative colitis

(2008) Tadayuki Oshima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site

(2008) Alan S.L. Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

(2008) Christopher R Weber et al.   LABORATORY INVESTIGATION