The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity

A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis

(2018) Lisa Göschl et al.   JOURNAL OF AUTOIMMUNITY

Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

(2017) Catherine J. Hutchings et al.   NATURE REVIEWS DRUG DISCOVERY

Mogamulizumab for the treatment of relapsed or refractory adult T-cell leukemia-lymphoma

(2017) Frank T. Winsett et al.   Expert Review of Hematology

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization

(2017) Douglas P. Dyer et al.   Open Biology

Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients

(2017) Timur Khaibullin et al.   Frontiers in Immunology

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

C-C chemokine receptor type 4 antagonist Compound 22 ameliorates experimental autoimmune encephalomyelitis

(2016) Kota Moriguchi et al.   JOURNAL OF NEUROIMMUNOLOGY

1,25-Dihydroxyvitamin D3 Facilitates M2 Polarization and Upregulates TLR10 Expression on Human Microglial Cells

(2016) Rewa Verma et al.   NEUROIMMUNOMODULATION

Atypical Chemokine Receptors and Their Roles in the Resolution of the Inflammatory Response

(2016) Raffaella Bonecchi et al.   Frontiers in Immunology

Fractalkine in the nervous system: neuroprotective or neurotoxic molecule?

(2015) Clotilde Lauro et al.   Annals of the New York Academy of Sciences

Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG)10-60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model

(2015) Y. S. Kap et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pharmacological Approaches to Delaying Disability Progression in Patients with Multiple Sclerosis

(2015) Heinz Wiendl et al.   DRUGS

Targeting chemokine receptors in disease – a case study of CCR4

(2015) Roberto Solari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The dependence of chemokine–glycosaminoglycan interactions on chemokine oligomerization

(2015) Douglas P Dyer et al.   GLYCOBIOLOGY

Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis

(2015) Laura A.N. Peferoen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IFN-β inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis

(2015) Wenjing Cheng et al.   MOLECULAR IMMUNOLOGY

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

(2015) Dayana Abboud et al.   Scientific Reports

T cell mediated pathogenesis in EAE: Molecular mechanisms

(2015) FlorianC Kurschus   Biomedical Journal

Current Perspectives on Interferon Beta-1b for the Treatment of Multiple Sclerosis

(2014) Martin Marziniak et al.   ADVANCES IN THERAPY

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

(2014) Laura Ajram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4

(2014) James Edward Pease et al.   Expert Opinion on Drug Discovery

CCR4 and its ligands: from bench to bedside

(2014) O. Yoshie et al.   INTERNATIONAL IMMUNOLOGY

The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

(2014) Joachim Burman et al.   JOURNAL OF NEUROIMMUNOLOGY

Disease-modifying therapy in multiple sclerosis and chronic inflammatory demyelinating polyradiculoneuropathy: common and divergent current and future strategies

(2013) N. Melzer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment

(2013) Theresa Globisch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The importance of CCR4 and CCR6 in experimental autoimmune encephalomyelitis

(2013) Kota Moriguchi et al.   JOURNAL OF NEUROIMMUNOLOGY

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

(2013) Anthony Cahn et al.   BMC Pharmacology & Toxicology

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Dendritic cells and alveolar macrophages mediate IL-13–induced airway inflammation and chemokine production

(2012) Margaret Crapster-Pregont et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-12 family cytokines: immunological playmakers

(2012) Dario A A Vignali et al.   NATURE IMMUNOLOGY

Reply to Othy et al.: Dendritic cell-specific expression of CCR4 is required for development of EAE

(2012) J. Alferink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of CC chemokine receptor 4 antagonism on the evolution of experimental autoimmune encephalomyelitis

(2012) S. Othy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells

(2012) K. Poppensieker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokine Receptor Requirements for Epidermal T-Cell Trafficking

(2011) Noah J. Tubo et al.   AMERICAN JOURNAL OF PATHOLOGY

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function

(2011) C.L. Salanga et al.   EXPERIMENTAL CELL RESEARCH

Cytokines and effector T cell subsets causing autoimmune CNS disease

(2011) Franziska Petermann et al.   FEBS LETTERS

CCL17 Promotes Intestinal Inflammation in Mice and Counteracts Regulatory T Cell–Mediated Protection From Colitis

(2011) Alexander F. Heiseke et al.   GASTROENTEROLOGY

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

(2011) Christian Weber et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

(2011) Joel Montane et al.   JOURNAL OF CLINICAL INVESTIGATION

CCR4 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by regulating inflammatory macrophage function

(2011) Eileen A. Forde et al.   JOURNAL OF NEUROIMMUNOLOGY

Quantitative differences in the immunomodulatory effects of Rebif and Avonex in IFN-β 1a treated multiple sclerosis patients

(2011) George P. Christophi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Immunological and clinical consequences of treating a patient with natalizumab

(2011) Nicholas Schwab et al.   Multiple Sclerosis Journal

Macrophage-Specific Chemokines Induced via Innate Immunity by Amino Acid Copolymers and Their Role in EAE

(2011) Joseph Kovalchin et al.   PLoS One

Identification of Human NK17/NK1 Cells

(2011) Abhilash D. Pandya et al.   PLoS One

Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma

(2010) T. Ishii et al.   CLINICAL CANCER RESEARCH

Expression and functional activity of chemokine receptors in glatiramer acetate–specific T cells isolated from multiple sclerosis patient receiving the drug glatiramer acetate

(2010) Rune Alexander Høglund et al.   HUMAN IMMUNOLOGY

CCL22 regulates experimental autoimmune encephalomyelitis by controlling inflammatory macrophage accumulation and effector function

(2010) Rukiye-Nazan E. Dogan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical study on CXCL13, CCL17, CCL20 and IL-17 as immune cell migration navigators in relapsing−remitting multiple sclerosis patients

(2010) Alicja Kalinowska-Łyszczarz et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs

(2010) Verena Semmling et al.   NATURE IMMUNOLOGY

Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells

(2010) S. Stutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EAE: An immunologist's magic eye

(2009) Gurumoorthy Krishnamoorthy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology

(2009) Richard M. Ransohoff   IMMUNITY

Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid

(2009) J. Mellergård et al.   Multiple Sclerosis Journal

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis

(2008) E Butti et al.   GENE THERAPY

Detrimental Role of CC Chemokine Receptor 4 in Murine Polymicrobial Sepsis

(2008) T. Traeger et al.   INFECTION AND IMMUNITY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

MDC/CCL22 intrathecal levels in patients with multiple sclerosis

(2008) D. Galimberti et al.   Multiple Sclerosis Journal

Chemokines and leukocyte traffic

(2008) Federica Sallusto et al.   NATURE IMMUNOLOGY

Fluorescence Resonance Energy Transfer Imaging Reveals that Chemokine-Binding Modulates Heterodimers of CXCR4 and CCR5 Receptors

(2008) Nilgun Isik et al.   PLoS One