Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4

Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma

(2013) Takashi Ishida et al.   CANCER SCIENCE

CCL17/thymus and activation-regulated chemokine induces calcitonin gene–related peptide in human airway epithelial cells through CCR4

(2013) Kandace Bonner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation

(2013) Roshi Afshar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation

(2013) Krisztian Gaspar et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4

(2013) Zamaneh Mikhak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthesis and Structure–Activity Relationships of Indazole Arylsulfonamides as Allosteric CC-Chemokine Receptor 4 (CCR4) Antagonists

(2013) Panayiotis A. Procopiou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

(2013) Anthony Cahn et al.   BMC Pharmacology & Toxicology

Discovery and structure–activity relationships of urea derivatives as potent and novel CCR3 antagonists

(2012) Aiko Nitta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: Optimising in vivo clearance

(2012) Mark Furber et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I

(2012) Mark Furber et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation

(2012) Panayiotis A. Procopiou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

(2012) Ash Bahl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists

(2012) Aiko Nitta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

(2012) Ash Bahl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The estimated prevalence and incidence of late stage age related macular degeneration in the UK

(2012) Christopher G Owen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

CCR3 induced-p42/44 MAPK activation protects against staurosporine induced-DNA fragmentation but not apoptosis in airway smooth muscle cells

(2012) L. J. Markwick et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mogamulizumab

(2012) Joshuan M. Subramaniam et al.   DRUGS

An Antagonist for CCR4 Alleviates Murine Allergic Rhinitis by Intranasal Administration

(2012) Hui Qi et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Chemokine Receptor Antagonists

(2012) James Pease et al.   JOURNAL OF MEDICINAL CHEMISTRY

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Targeting chemokine receptors in allergic disease

(2011) James E. Pease   BIOCHEMICAL JOURNAL

A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens

(2011) H. Pere et al.   BLOOD

Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR4

(2011) O. Kaminuma et al.   CLINICAL AND EXPERIMENTAL ALLERGY

TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge

(2011) H. Imaoka et al.   CLINICAL AND EXPERIMENTAL ALLERGY

CC and CXC Chemokines Induce Airway Smooth Muscle Proliferation and Survival

(2011) Rabih Halwani et al.   JOURNAL OF IMMUNOLOGY

Monoclonal antibodies for the treatment of asthma

(2011) Matthew C. Catley et al.   PHARMACOLOGY & THERAPEUTICS

CCR3 and Choroidal Neovascularization

(2011) Yiwen Li et al.   PLoS One

Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis

(2011) Maria C. Lebre et al.   PLoS One

A Novel CC Chemokine Receptor 4 Antagonist RS-1269 Inhibits Ovalbumin-Induced Ear Swelling and Lipopolysaccharide-Induced Endotoxic Shock in Mice

(2010) Yasuhiro Nakagami et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

RS-1748, a Novel CC Chemokine Receptor 4 Antagonist, Inhibits Ovalbumin-Induced Airway Inflammation in Guinea Pigs

(2010) Yasuhiro Nakagami et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The eosinophil and airway remodelling in asthma

(2010) Per Venge   Clinical Respiratory Journal

Small Molecule Antagonists of Chemokine Receptors - is Promiscuity a Virtue?

(2010) James E. Pease et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Eotaxin-3/CC Chemokine Ligand 26 Is a Functional Ligand for CX3CR1

(2010) T. Nakayama et al.   JOURNAL OF IMMUNOLOGY

CXC Chemokine Ligand 4 Induces a Unique Transcriptome in Monocyte-Derived Macrophages

(2010) C. A. Gleissner et al.   JOURNAL OF IMMUNOLOGY

Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients

(2010) P. Vijayanand et al.   JOURNAL OF IMMUNOLOGY

Role of the Chemokine Receptors CCR1, CCR2 and CCR4 in the Pathogenesis of Experimental Dengue Infection in Mice

(2010) Rodrigo Guabiraba et al.   PLoS One

Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice

(2009) Yasuhiro Nakagami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CCR3 antagonists: a survey of the patent literature

(2009) Leyi Gong et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chemokine receptor antagonists: Part 1

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

CCR3 is a target for age-related macular degeneration diagnosis and therapy

(2009) Atsunobu Takeda et al.   NATURE

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibitory Effect of the New Orally Active CCR4 Antagonist K327 on CCR4+CD4+ T Cell Migration into the Lung of Mice with Ovalbumin-Induced Lung Allergic Inflammation

(2009) Takashi Sato et al.   PHARMACOLOGY

Antisense Therapy against CCR3 and the Common Beta Chain Attenuates Allergen-induced Eosinophilic Responses

(2008) Gail M. Gauvreau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition

(2008) Ippei Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of potent CCR4 antagonists: Synthesis and structure–activity relationship study of 2,4-diaminoquinazolines

(2008) Kazuhiro Yokoyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent CCR4 antagonists: Synthesis, evaluation, and docking study of 2,4-diaminoquinazolines

(2008) Kazuhiro Yokoyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Potent and orally bioavailable CCR4 antagonists: Synthesis and structure–activity relationship study of 2-aminoquinazolines

(2008) Kazuhiro Yokoyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Urea based CCR3 antagonists employing a tetrahydro-1,3-oxazin-2-one spacer

(2008) T.G. Murali Dhar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemokine receptor antagonists: overcoming developmental hurdles

(2008) Richard Horuk   NATURE REVIEWS DRUG DISCOVERY

Novel anti-inflammatory treatments for asthma

(2008) Binita Bhowmick et al.   Expert Review of Respiratory Medicine

Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists

(2007) Ippei Sato et al.   BIOORGANIC & MEDICINAL CHEMISTRY

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: The discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis

(2007) Joseph B. Santella et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS