Article
Immunology
Samuel J. Duesman, Sandra Ortega-Francisco, Roxana Olguin-Alor, Naray A. Acevedo-Dominguez, Christine M. Sestero, Rajeshwari Chellappan, Patrizia De Sarno, Nabiha Yusuf, Adrian Salgado-Lopez, Marisol Segundo-Liberato, Selina Montes de Oca-Lagunas, Chander Raman, Gloria Soldevila
Summary: The transforming growth factor receptor III (T beta RIII) is a co-receptor that regulates T cell development in the immune system and controls the pathogenicity of autoreactive T cells in neuroinflammation. T beta RIII null mice showed increased severity of autoimmune central nervous neuroinflammatory disease and expanded numbers of IFN gamma(+) CD4(+) T cells. This suggests that T beta RIII may be involved in regulating the conversion of encephalitogenic Th17 to Th1 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Anna Waskiel-Burnat, Marta Osinska, Anna Salinska, Leszek Blicharz, Mohamad Goldust, Malgorzata Olszewska, Lidia Rudnicka
Summary: Alopecia areata is characterized by dysregulation of various systemic cytokines including Th1, Th2, and Th17. The severity and duration of the disease are positively correlated with elevated levels of certain cytokines, while others may serve as potential predictors of therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Monica M. Van Acker, Rebekah R. Schwartz, Kelly Andrews, Kristina Seiffert-Sinha, Animesh A. Sinha
Summary: This study found that blood relatives of AA patients show similar elevation of Th1 and Th17 pathway cytokines, suggesting a genetic basis for Th1 and Th17 dysregulation in AA. The elevation of Th17-related cytokines in an unrelated control individual may suggest predictive value.
Article
Immunology
Wen-Tsan Weng, Ping-Chang Kuo, Dennis A. Brown, Barbara A. Scofield, Destin Furnas, Hallel C. Paraiso, Pei-Yu Wang, I-Chen Yu, Jui-Hung Yen
Summary: This study demonstrated that 4-EG has therapeutic effects in EAE by modulating neuroinflammation, inhibiting Th1 and Th17 differentiation, and suppressing inflammatory immune responses in the CNS and periphery. This suggests that 4-EG, a natural compound found in foods, could potentially be developed as a therapeutic agent for the treatment of MS/EAE.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Guangyu Liu, Xiangrui Jiang, Mengyao Han, Jie Lv, Wei Zhuang, Ling Xie, Yan Zhang, Chun Wang, Kaidireya Saimaier, Jingshu Yang, Jingshan Shen, Ning Li, Changsheng Du
Summary: This study demonstrates that TPN10466 provides protection against the autoimmune disease EAE by inhibiting immune cell migration and suppressing Th1/Th17 differentiation.
CELLULAR IMMUNOLOGY
(2022)
Article
Neurosciences
Mushtaq A. Ansari, Ahmed Nadeem, Musaad A. Alshammari, Sabry M. Attia, Saleh A. Bakheet, Mohammad R. Khan, Thamer H. Albekairi, Abdullah F. Alasmari, Khaled Alhosaini, Faleh Alqahtani, Haneen A. Al-Mazroua, Sheikh F. Ahmad
Summary: This study investigated the role of Cathepsin B inhibitor CA-074 in the progression of multiple sclerosis (MS). The results showed that CA-074 reduced clinical scores and suppressed the activity of key immune cells in EAE mice. Furthermore, it downregulated the expression of related genes and proteins. These findings suggest that Cathepsin B could be a potential therapeutic candidate for the treatment of MS.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Immunology
Hannes Lindahl, Tomas Olsson
Summary: IL-22 is a significant interleukin that plays a crucial role in the immune system and tissue repair, particularly in T cell-driven inflammatory diseases. Its influence on T cells has not been fully understood so far, and further research is needed to explore its role in promoting regulatory T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Javad Rasouli, Giacomo Casella, Larissa L. W. Ishikawa, Rodolfo Thome, Alexandra Boehm, Adam Ertel, Carolina R. Melo-Silva, Elisabeth R. Mari, Patrizia Porazzi, Weifeng Zhang, Dan Xiao, Luis J. Sigal, Paolo Fortina, Guang-Xian Zhang, Abdolmohamad Rostami, Bogoljub Ciric
Summary: The study reveals that IFN-beta therapy reduces GM-CSF production by Th cells indirectly through its effects on monocytes, and increases IL-10 expression in monocytes to suppress IL-1 beta secretion, thereby disrupting a proinflammatory loop involving several molecules derived from Th cells and monocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Chen Dai, Xi Zhou, Lu Wang, Rumeng Tan, Wei Wang, Bo Yang, Yucong Zhang, Huibo Shi, Dong Chen, Lai Wei, Zhishui Chen
Summary: Rocaglamide exhibits antirejection effect in a mouse cardiac allograft model by regulating T cell subset balance and cytokine network. It prolongs the survival of heart grafts, reduces inflammatory cell infiltration and organ injury, and inhibits NF-AT activation.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Immunology
Lifei Hou, Koichi Yuki
Summary: This study found that CD4 T cells with cytotoxic properties in experimental autoimmune encephalomyelitis (EAE) were positive for both CXCR6 and CCR6 markers. The CD4 T cells infiltrating the spinal cord showed high cytotoxicity, expressing Granzyme(s), IFN gamma, and GM-CSF. These findings highlight the importance of cytotoxicity in EAE pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Junjie Zhao, Yun Liao, William Miller-Little, Jianxing Xiao, Caini Liu, Xiaoxia Li, Xiao Li, Zizhen Kang
Summary: This study identified STEAP4 as a Th17-specific effector molecule that plays a key role in the pathogenesis of neuroinflammation. STEAP4 knockout mice showed delayed onset and reduced severity of EAE induced by active immunization. Notably, STEAP4 was only induced in the spinal cord of EAE mice that received Th17 cells, indicating its specific role in Th17-mediated neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Naomi M. Fettig, Hannah G. Robinson, Jessica R. Allanach, Katherine M. Davis, Rachel L. Simister, Elsie J. Wang, Andrew J. Sharon, Jiayu Ye, Sarah J. Popple, Jung Hee Seo, Deanna L. Gibson, Sean A. Crowe, Marc S. Horwitz, Lisa C. Osborne
Summary: The study found that different sources of dietary fiber have different effects on the immune system. Guar gum can delay the progression of disease and neuroinflammation in a mouse model of multiple sclerosis. These effects are not related to fiber-induced changes in short-chain fatty acid levels or regulatory CD4(+) T cells, but are associated with reduced activation, proliferation, Th1 differentiation, and altered migratory potential of CD4(+) T cells.
Article
Biochemistry & Molecular Biology
Antti Pemmari, Tiina Leppanen, Mari Hamalainen, Teemu Moilanen, Eeva Moilanen
Summary: Chronic low-grade inflammation is central in the pathogenesis of osteoarthritis, and cytokines such as IFN gamma, IL-1 beta, IL-4 and IL-17 are associated with phenotypic changes in chondrocytes. The gene expression in OA chondrocytes is significantly altered by these cytokines, with distinct profiles observed for different cytokines, indicating potential phenotypic plasticity in arthritis pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Barbara Pesce, Carolina H. Ribeiro, Milton Larrondo, Veronica Ramos, Lilian Soto, Diego Catalan, Juan Carlos Aguillon
Summary: Tumor necrosis factor (TNF)-alpha regulates cytokine production by CD4+ T helper cells, and targeting TNFR2 may be an alternative strategy to normalize key cytokine levels that contribute to the pathogenesis of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Xuefei Wang, Chen Chen, Hongwei Sun, Kaiqiong Mao, Jiameng Yao, Weiqiao Zhang, Meixiao Zhan, Hua-Bing Li, Zhiren Zhang, Shu Zhu, Ligong Lu
Summary: N-6-methyladenosine (m(6)A) is an important epigenetic RNA modification that regulates mRNA metabolism and plays a role in cell differentiation, proliferation, and response to stimulation. In this study, the role of m(6)A methyltransferase METTL3 in T helper cells 17 (Th17) was investigated. The loss of METTL3 was found to impede Th17 cell differentiation and the development of experimental autoimmune encephalomyelitis (EAE), a Th17 cell-mediated autoimmune disease. Depletion of METTL3 attenuated IL-17A and CCR5 expression by stabilizing SOCS3 mRNA, leading to disrupted Th17 cell differentiation and infiltration and attenuating EAE process.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Parasitology
Yan Fang, Chenyun Wu, Qing Chen, Jianhua Wu, Yang Yang, Xiaokui Guo, Guangjie Chen, Zhaojun Wang
Article
Immunology
Thomas P. Porturas, Honghong Sun, George Buchlis, Yunwei Lou, Xiaohong Liang, Terry Cathopoulis, Svetlana Fayngerts, Derek S. Johnson, Zhaojun Wang, Youhai H. Chen
JOURNAL OF IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Xiaoyin Niu, Shaohua Deng, Shan Li, Yebin Xi, Chengzhen Li, Li Wang, Dongyi He, Zhaojun Wang, Guangjie Chen
MOLECULAR MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Yimin Lao, Kai Yang, Zhaojun Wang, Xueqing Sun, Qiang Zou, Xiaoyan Yu, Jinke Cheng, Xuemei Tong, Edward T. H. Yeh, Jie Yang, Jing Yi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Immunology
Cennan Yin, Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jianhua Wu, Lili Tang, Wei Zhao, Yongqiang Weng, Xiaokui Guo, Guangjie Chen, Zhaojun Wang
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xinyue Du, Yang Zhang, Xiao Li, Qi Li, Chenyun Wu, Guangjie Chen, XiaoKui Guo, Yongqiang Weng, Zhaojun Wang
CELL AND BIOSCIENCE
(2019)
Article
Immunology
Chenyun Wu, Xinyue Du, Lili Tang, Jianhua Wu, Wei Zhao, Xiaokui Guo, Dengyu Liu, Wei Hu, Helena Helmby, Guangjie Chen, Zhaojun Wang
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ting Wu, Yunxuan Lei, Shuxin Jin, Qing Zhao, Wenjing Cheng, Yebin Xi, Li Wang, Zhaojun Wang, Xiaoyin Niu, Guangjie Chen
Summary: This study demonstrated that miRNA-467b inhibits the differentiation and function of Th17 cells by targeting eIF4E, thereby alleviating the development of EAE.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Zhidan Li, Wei Zhang, Fang Luo, Jian Li, Wenbin Yang, Bingkuan Zhu, Qunfeng Wu, Xiaoling Wang, Chengsong Sun, Yuxiang Xie, Bin Xu, Zhaojun Wang, Feng Qian, Jiaxu Chen, Yanmin Wan, Wei Hu
Summary: Lung-stage Schistosoma japonicum infection protects against OVA-induced asthma by upregulating Treg cells in lung tissue to suppress IgE production.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Feiyang Cai, Sailiang Liu, Yunxuan Lei, Shuxin Jin, Zizhen Guo, Dehao Zhu, Xin Guo, Hanqing Zhao, Xiaoyin Niu, Yebin Xi, Zhaojun Wang, Guangjie Chen
Summary: The study demonstrates that EGCG can reduce the severity of EAE and macrophage inflammation in the CNS. Additionally, EGCG inhibits inflammation in M1 macrophages and promotes polarization of M2 macrophages.
CELLULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi Li, Tao Yue, Xinyue Du, Zaiming Tang, Jinjie Cui, Weifeng Wang, Wenjie Xia, Baiyang Ren, Shuo Kan, Chang Li, Chenyun Wu, Xiaoyin Niu, Bin Li, Kaili Lin, Jian Luo, Guangjie Chen, Zhaojun Wang
Summary: Inflammation leads to osteoporosis or bone destruction, and PRL2 is identified as a negative regulator involved in bone health by modulating osteoclast differentiation and bone resorption. The study reveals that during inflammation, oxidized PRL2 is rapidly degraded through autophagy, which exacerbates osteoclast numbers and bone damage. Additionally, decreased PRL2 levels are associated with bone destruction, and inhibition of autophagy can prevent bone damage. Therefore, PRL2 could be a potential target for treating inflammatory bone diseases.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Hanqing Zhao, Xin Guo, Yunxuan Lei, Wenjie Xia, Feiyang Cai, Dehao Zhu, Yang An, Yebin Xi, Xiaoyin Niu, Zhaojun Wang, Tao Yue, Guangjie Chen
Summary: This study demonstrated the inhibitory effects of gamma-Tocotrienol (GT3) on Th17 differentiation and function through the suppression of STAT3 signaling pathway both in vitro and in vivo. GT3 may have potential therapeutic effects in treating Th17-related diseases.
MOLECULAR IMMUNOLOGY
(2022)
Article
Infectious Diseases
Shuo Kan, Qi Li, Hong-Mei Li, Yan-Hua Yao, Xin-Yue Du, Chen-Yun Wu, Guang-Jie Chen, Xiao-Kui Guo, Men-Bao Qian, Zhao-Jun Wang
Summary: This study investigated the impact of Clonorchis sinensis infection on host immune response and found that infected individuals had higher levels of specific IgG and IgE. Females showed weaker IgE antibody enhancement compared to males. C. sinensis infection resulted in decreased levels of certain cytokines in sera, with more significant changes observed in females. These findings provide a better understanding of the long-term immune alteration caused by C. sinensis infection.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Svetlana A. Fayngerts, Zhaojun Wang, Ali Zamani, Honghong Sun, Amanda E. Boggs, Thomas P. Porturas, Weidong Xie, Mei Lin, Terry Cathopoulis, Jason R. Goldsmith, Anastassios Vourekas, Youhai H. Chen