期刊
PEPTIDES
卷 29, 期 3, 页码 440-447出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2007.11.005
关键词
POMC; MSH; melanocortin 3-receptor; feeding
资金
- NIDDK NIH HHS [R01 DK017420, R01 DK017420-32, R01 DK057561, R01 DK057561-04, DK 57561, DK 17420] Funding Source: Medline
- NIMH NIH HHS [R01 MH055708-09, MH 55708, R01 MH055708] Funding Source: Medline
Hypothalamic POMC neurons regulate energy balance via interactions with brain melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can function as an inhibitory autoreceptor in vitro. We now demonstrate that central activation of MC3-R with ICV infusion of the specific MC3-R agonist, [D-Trp(8)]-gamma-MSH, transiently suppresses hypothalamic Pomc expression and stimulates food intake in rats. Conversely, we also show that ICV infusion of a low dose of a selective MC3-R antagonist causes a transient decrease in feeding and weight gain. These data support a functional inhibitory role for the MC3-R on POMC neurons that leads to changes in food intake. (c) 2007 Elsevier Inc. All rights reserved.
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