Molecular and Genetic Determinants of Glioma Cell Invasion

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

(2017) Yuchao Gu et al.   MOLECULAR CELL

Shifting the optimal stiffness for cell migration

(2017) Benjamin L. Bangasser et al.   Nature Communications

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling

(2016) Kenta Masui et al.   BIOESSAYS

Cancer metabolism as a central driving force of glioma pathogenesis

(2016) Kenta Masui et al.   Brain Tumor Pathology

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Resetting cancer stem cell regulatory nodes upon MYC inhibition

(2016) Silvia Galardi et al.   EMBO REPORTS

Glioblastoma: pathology, molecular mechanisms and markers

(2015) Kenneth Aldape et al.   ACTA NEUROPATHOLOGICA

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

(2015) Kensuke Tateishi et al.   CANCER CELL

Metabolic reprogramming supports the invasive phenotype in malignant melanoma

(2015) Ingrid J. Bettum et al.   CANCER LETTERS

Mechanisms regulating glioma invasion

(2015) Ivy Paw et al.   CANCER LETTERS

Constitutive Activation of Myosin-Dependent Contractility Sensitizes Glioma Tumor-Initiating Cells to Mechanical Inputs and Reduces Tissue Invasion

(2015) S. Y. Wong et al.   CANCER RESEARCH

Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion

(2015) Andrew S. Gilder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significance of filamin A in mTORC2 function in glioblastoma

(2015) Naphat Chantaravisoot et al.   Molecular Cancer

Insulator dysfunction and oncogene activation in IDH mutant gliomas

(2015) William A. Flavahan et al.   NATURE

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

(2015) Kenta Masui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma

(2015) Monica Venere et al.   Science Translational Medicine

CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion

(2015) Pengcheng Zhou et al.   Oncotarget

EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis

(2015) Zhaoyu Liu et al.   Oncotarget

Overexpression of miR-145 in U87 cells reduces glioma cell malignant phenotype and promotes survival after in vivo implantation

(2014) YONG LU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Glucose-6–phosphatase Is a Key Metabolic Regulator of Glioblastoma Invasion

(2014) Sara Abbadi et al.   MOLECULAR CANCER RESEARCH

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

Tumor cells in search for glutamate: an alternative explanation for increased invasiveness of IDH1 mutant gliomas

(2014) S. A. M. van Lith et al.   NEURO-ONCOLOGY

Invasion and proliferation kinetics in enhancing gliomas predict IDH1 mutation status

(2014) Anne L. Baldock et al.   NEURO-ONCOLOGY

mTORC2 in the center of cancer metabolic reprogramming

(2014) Kenta Masui et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis

(2013) Krishna M. Talasila et al.   ACTA NEUROPATHOLOGICA

ADAM17 promotes U87 glioblastoma stem cell migration and invasion

(2013) Xiangrong Chen et al.   BRAIN RESEARCH

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Intracellular NAD(H) levels control motility and invasion of glioma cells

(2013) Remco van Horssen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epidermal Growth Factor (EGF)-enhanced Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression Promotes Macrophage and Glioblastoma Cell Interaction and Tumor Cell Invasion

(2013) Yanhua Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma

(2013) Chunzhi Zhang et al.   NEURO-ONCOLOGY

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Glioma derived isocitrate dehydrogenase-2 mutations induced up-regulation of HIF-1α and β-catenin signaling: Possible impact on glioma cell metastasis and chemo-resistance

(2012) Yuejun Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma

(2012) D Kesanakurti et al.   Cell Death & Disease

Angiogenesis and invasion in glioma

(2011) Manabu Onishi et al.   Brain Tumor Pathology

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies

(2011) K. Masui et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion and metastasis

(2011) E K Kim et al.   ONCOGENE

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

(2010) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation

(2010) Kenta Masui et al.   GLIA

Epidermal Growth Factor Receptor-Mediated Regulation of Urokinase Plasminogen Activator Expression and Glioblastoma Invasion via C-SRC/MAPK/AP-1 Signaling Pathways

(2010) Samson Amos et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

(2010) Svetlana A Mikheeva et al.   Molecular Cancer

Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells

(2010) Gowry Das et al.   MOLECULAR CARCINOGENESIS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isoform-Specific Contributions of α-Actinin to Glioma Cell Mechanobiology

(2009) Shamik Sen et al.   PLoS One

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells

(2008) Kenta Masui et al.   Brain Tumor Pathology

The Role of Myosin II in Glioma Invasion of the Brain

(2008) Christopher Beadle et al.   MOLECULAR BIOLOGY OF THE CELL

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

AMPA receptors promote perivascular glioma invasion via β1 integrin–dependent adhesion to the extracellular matrix

(2008) Yuji Piao et al.   NEURO-ONCOLOGY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE