Associations of Drug Lipophilicity and Extent of Metabolism with Drug-Induced Liver Injury

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

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RUCAM in Drug and Herb Induced Liver Injury: The Update

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Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications

(2015) Zuquan Weng et al.   Oncotarget

Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives

(2014) Robert J. Fontana   GASTROENTEROLOGY

Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data

(2014) Xiao Zhu et al.   TOXICOLOGY

Avoiding idiosyncratic DILI: Two is better than one

(2013) Neil Kaplowitz   HEPATOLOGY

Drug-Induced Liver Injury: The Role of Drug Metabolism and Transport

(2013) Alberto Corsini et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Serum acute phase reactants hallmark healthy individuals at risk for acetaminophen-induced liver injury

(2013) Jürgen Borlak et al.   Genome Medicine

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

(2012) Melanie Z. Sakatis et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury

(2012) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R

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Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

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Evaluation of Naranjo Adverse Drug Reactions Probability Scale in causality assessment of drug-induced liver injury

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Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase™

(2010) Ayako Suzuki et al.   DRUG SAFETY

Risk Factors for Idiosyncratic Drug-Induced Liver Injury

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

Phenotypic characterization of idiosyncratic drug-induced liver injury: The influence of age and sex

(2009) M. Isabel Lucena et al.   HEPATOLOGY

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES