Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression
出版年份 2015 全文链接
标题
Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression
作者
关键词
<em class=EmphasisTypeItalic >IFIH1</em>/melanoma differentiation-associated protein 5/MDA5, rs1990760/A946T, rs3747517/R843H, rs35667974/I923V, Type I interferon
出版物
Current Diabetes Reports
Volume 15, Issue 11, Pages -
出版商
Springer Nature
发表日期
2015-09-18
DOI
10.1007/s11892-015-0656-8
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection
- (2015) Cherie T. Ng et al. Cell Host & Microbe
- Increased Levels of Type 1 Interferon in a Type 1 Diabetic Mouse Model Induce the Elimination of B Cells from the Periphery by Apoptosis and Increase their Retention in the Spleen
- (2015) Badr Mohamed Badr et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Viral RNA detection by RIG-I-like receptors
- (2015) Mitsutoshi Yoneyama et al. CURRENT OPINION IN IMMUNOLOGY
- Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?: Figure 1
- (2015) Teresa Rodriguez-Calvo et al. DIABETES
- Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
- (2015) David M. Blodgett et al. DIABETES
- Cumulative effect of IFIH1 variants and increased gene expression associated with type 1 diabetes
- (2015) Magdalena Zurawek et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- ATP-Dependent Effector-like Functions of RIG-I-like Receptors
- (2015) Hui Yao et al. MOLECULAR CELL
- Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility
- (2015) Xianyong Yin et al. Nature Communications
- A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
- (2014) R. C. Ferreira et al. DIABETES
- Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility
- (2014) H. Kallionpaa et al. DIABETES
- Increased IFN- -Producing Plasmacytoid Dendritic Cells (pDCs) in Human Th1-Mediated Type 1 Diabetes: pDCs Augment Th1 Responses through IFN- Production
- (2014) C.-Q. Xia et al. JOURNAL OF IMMUNOLOGY
- Interferon-λ in the Context of Viral Infections: Production, Response and Therapeutic Implications
- (2014) Pascale Hermant et al. Journal of Innate Immunity
- An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
- (2014) Faruk Sheikh et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Coxsackievirus can persist in murine pancreas by deletion of 5′ terminal genomic sequences
- (2014) Steven Tracy et al. JOURNAL OF MEDICAL VIROLOGY
- The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly
- (2014) Annie M. Bruns et al. MOLECULAR CELL
- Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
- (2014) Gillian I Rice et al. NATURE GENETICS
- Diverse intracellular pathogens activate type III interferon expression from peroxisomes
- (2014) Charlotte Odendall et al. NATURE IMMUNOLOGY
- High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5
- (2014) Jie Zheng et al. NUCLEIC ACIDS RESEARCH
- Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV
- (2014) Stephen M. Laidlaw et al. Frontiers in Immunology
- Functional characterization of the Thr946Ala SNP at the type 1 diabetesIFIH1locus
- (2013) Hana Zouk et al. AUTOIMMUNITY
- Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis
- (2013) I. Santin et al. DIABETES OBESITY & METABOLISM
- The diagnosis of insulitis in human type 1 diabetes
- (2013) M. L. Campbell-Thompson et al. DIABETOLOGIA
- Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling
- (2013) Effi Wies et al. IMMUNITY
- Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets
- (2013) K. Lind et al. JOURNAL OF VIROLOGY
- Type 1 diabetes
- (2013) Mark A Atkinson et al. LANCET
- Functional Characterization of Domains of IPS-1 Using an Inducible Oligomerization System
- (2013) Shiori Takamatsu et al. PLoS One
- Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production
- (2013) Julio E. Molineros et al. PLoS Genetics
- Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5
- (2012) Bin Wu et al. CELL
- Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction
- (2012) P. Ylipaasto et al. DIABETOLOGIA
- MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA
- (2012) Ian C Berke et al. EMBO JOURNAL
- Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response
- (2012) Xiaomo Jiang et al. IMMUNITY
- Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments
- (2012) A. Peisley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
- (2011) Fajian Hou et al. CELL
- An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes
- (2011) C. Winkler et al. DIABETES
- Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN- and Serologic Autoimmunity in Lupus Patients
- (2011) T. Robinson et al. JOURNAL OF IMMUNOLOGY
- Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
- (2011) A. Peisley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulitis in human type 1 diabetes
- (2011) Peter In't Veld Islets
- Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections
- (2010) Guanjun Cheng et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)–induced interferon-β production in peripheral blood mononuclear cells of type 1 diabetes patients
- (2010) Dimitry A. Chistiakov et al. HUMAN IMMUNOLOGY
- Etiology of Type 1 Diabetes
- (2010) John A. Todd IMMUNITY
- Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF- B than Type I IFNs
- (2010) M. B. Iversen et al. JOURNAL OF VIROLOGY
- Phosphorylation-Mediated Negative Regulation of RIG-I Antiviral Activity
- (2010) M. U. Gack et al. JOURNAL OF VIROLOGY
- MDA5 is SUMOylated by PIAS2β in the upregulation of Type I interferon signaling
- (2010) Jihuan Fu et al. MOLECULAR IMMUNOLOGY
- Study of Transcriptional Effects in Cis at the IFIH1 Locus
- (2010) Hana Zouk et al. PLoS One
- Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes
- (2010) Kate Downes et al. PLoS One
- Type I interferon in organ-targeted autoimmune and inflammatory diseases
- (2010) Mary K Crow ARTHRITIS RESEARCH & THERAPY
- The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations
- (2009) A. Jermendy et al. DIABETOLOGIA
- IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype–phenotype correlation in the Belgian population
- (2009) Folefac Aminkeng et al. HUMAN IMMUNOLOGY
- MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
- (2009) Maikel L. Colli et al. HUMAN MOLECULAR GENETICS
- Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2
- (2009) Darja Bamming et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5
- (2009) Taeko Shigemoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
- (2009) S. Nejentsev et al. SCIENCE
- A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
- (2008) P. Concannon et al. DIABETES
- The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes
- (2008) S. Fourlanos et al. DIABETES CARE
- IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells
- (2008) S. Liu et al. HUMAN MOLECULAR GENETICS
- Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
- (2008) Hiroki Kato et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Interferon-β Pretreatment of Conventional and Plasmacytoid Human Dendritic Cells Enhances Their Activation by Influenza Virus
- (2008) Hannah Phipps-Yonas et al. PLoS Pathogens
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