High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

(2014) Alys Peisley et al.   NATURE

Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors

(2014) Dahai Luo   RNA Biology

Structural basis for the prion-like MAVS filaments in antiviral innate immunity

(2014) Hui Xu et al.   eLife

Crystal and solution structure of the human RIG-I SF2 domain

(2014) Tobias Deimling et al.   Acta Crystallographica Section F-Structural Biology Communications

Defining the functional determinants for RNA surveillance by RIG-I

(2013) Andrew Kohlway et al.   EMBO REPORTS

Master sensors of pathogenic RNA – RIG-I like receptors

(2013) Martin Schlee   IMMUNOBIOLOGY

RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent, Ubiquitin-Independent Manner

(2013) Alys Peisley et al.   MOLECULAR CELL

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

(2013) Simone A. Beckham et al.   NUCLEIC ACIDS RESEARCH

Protein Conformation Ensembles Monitored by HDX Reveal a Structural Rationale for Abscisic Acid Signaling Protein Affinities and Activities

(2013) Graham M. West et al.   STRUCTURE

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Structural insights into RNA recognition and activation of RIG-I-like receptors

(2012) Daisy W Leung et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

(2012) Ian C Berke et al.   EMBO JOURNAL

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

HDX Workbench: Software for the Analysis of H/D Exchange MS Data

(2012) Bruce D. Pascal et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

MDA5 assembles into a polar helical filament on dsRNA

(2012) I. C. Berke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments

(2012) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Duplex RNA activated ATPases (DRAs)

(2012) Dahai Luo et al.   RNA Biology

A structure-based model of RIG-I activation

(2012) D. Kolakofsky et al.   RNA

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

(2012) Dahai Luo et al.   STRUCTURE

Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation

(2012) Fabien Ferrage et al.   STRUCTURE

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Escherichia coliProcessivity Clamp β from DNA Polymerase III Is Dynamic in Solution

(2011) Jing Fang et al.   BIOCHEMISTRY

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Activation of RIG-I-like receptor signal transduction

(2011) Annie M. Bruns et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

(2011) Filiz Civril et al.   EMBO REPORTS

Structural insights into the activation of RIG-I, a nanosensor for viral RNAs

(2011) Qiu-Xing Jiang et al.   EMBO REPORTS

Differential hydrogen/deuterium exchange mass spectrometry analysis of protein–ligand interactions

(2011) Michael J Chalmers et al.   Expert Review of Proteomics

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)

(2011) Marco Binder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential recognition of viral RNA by RIG-I

(2011) Alina Baum et al.   Virulence

RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity

(2011) Hilario J Ramos et al.   Current Opinion in Virology

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

(2010) Yanli Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate

(2010) Cheng Lu et al.   NUCLEIC ACIDS RESEARCH

Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer

(2010) Jun Zhang et al.   STRUCTURE

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

(2010) Cheng Lu et al.   STRUCTURE

Hydrogen/Deuterium Exchange Analysis of HIV-1 Capsid Assembly and Maturation

(2010) Eric B. Monroe et al.   STRUCTURE

Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

(2009) Xiaojun Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS