期刊
MOLECULAR CELL
卷 58, 期 3, 页码 541-548出版社
CELL PRESS
DOI: 10.1016/j.molcel.2015.03.014
关键词
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资金
- Chinese Scholarship Council
- Deutsche Forschungsgemeinschaft
- [AI106912]
- [AI111784]
- [AI091707]
The vertebrate antiviral innate immune system is often considered to consist of two distinct groups of proteins: pattern recognition receptors (PRRs) that detect viral infection and induce the interferon (IFN) signaling, and effectors that directly act against viral replication. Accordingly, previous studies on PRRs, such as RIG-I and MDA5, have primarily focused on their functions in viral double-stranded RNA (dsRNA) detection and consequent antiviral signaling. We report here that both RIG-I and MDA5 efficiently displace viral proteins pre-bound to dsRNA in a manner dependent on their ATP hydrolysis, and that this activity assists a dsRNA-dependent antiviral effector protein, PKR, and allows RIG-I to promote MDA5 signaling. Furthermore, truncated RIG-I/MDA5 lacking the signaling domain, and hence the IFN stimulatory activity, displaces viral proteins and suppresses replication of certain viruses in an ATP-dependent manner. Thus, this study reveals novel effector-like'' functions of RIG-I and MDA5 that challenge the conventional view of PRRs.
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