The role of the interleukin-1 family in trained immunity

Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism

(2017) Benjamin S. Durham et al.   JOURNAL OF NEUROCHEMISTRY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

(2016) Siroon Bekkering et al.   ATHEROSCLEROSIS

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

(2016) Janna A. van Diepen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In VitroExperimental Model of Trained Innate Immunity in Human Primary Monocytes

(2016) Siroon Bekkering et al.   Clinical and Vaccine Immunology

Suppression of innate inflammation and immunity by interleukin-37

(2016) Charles A. Dinarello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

Epigenetic drug discovery: breaking through the immune barrier

(2016) David F. Tough et al.   NATURE REVIEWS DRUG DISCOVERY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Immunometabolic circuits in trained immunity

(2016) Rob J.W. Arts et al.   SEMINARS IN IMMUNOLOGY

Immunometabolic Pathways in BCG-Induced Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Reports

Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs

(2016) Danielle M. Clancy et al.   FEBS Open Bio

An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism

(2015) Sanne P. Smeekens et al.   CYTOKINE

Role of IL-38 and Its Related Cytokines in Inflammation

(2015) Xianli Yuan et al.   MEDIATORS OF INFLAMMATION

IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

(2015) Claudia A Nold-Petry et al.   NATURE IMMUNOLOGY

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

(2015) Suzhao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of IL-33 and mast cells in allergy and inflammation

(2015) Rohit Saluja et al.   Clinical and Translational Allergy

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage activation syndrome and cytokine-directed therapies

(2014) Grant S. Schulert et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Preactivation with IL-12, IL-15, and IL-18 Induces CD25 and a Functional High-Affinity IL-2 Receptor on Human Cytokine-Induced Memory-like Natural Killer Cells

(2014) Jeffrey W. Leong et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

(2014) Johanneke Kleinnijenhuis et al.   CLINICAL IMMUNOLOGY

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection

(2014) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

(2014) Peter Aaby et al.   NATURE IMMUNOLOGY

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Trained innate immunity and atherosclerosis

(2013) Siroon Bekkering et al.   CURRENT OPINION IN LIPIDOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS

(2013) G. Ristori et al.   NEUROLOGY

Biology of IL-36 cytokines and their role in disease

(2013) Mark S. Gresnigt et al.   SEMINARS IN IMMUNOLOGY

A small jab – a big effect: nonspecific immunomodulation by vaccines

(2013) Christine S. Benn et al.   TRENDS IN IMMUNOLOGY

Interleukin-18 and IL-18 Binding Protein

(2013) Charles A. Dinarello et al.   Frontiers in Immunology

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

The IL-36 receptor pathway regulatesAspergillus fumigatus-induced Th1 and Th17 responses

(2012) Mark S. Gresnigt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages

(2012) Francesca Bellora et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

(2012) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity

(2011) Jennifer E. Towne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis

(2011) Yijun Carrier et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

The role of interleukin-18 in the metabolic syndrome

(2010) Marius Trøseid et al.   Cardiovascular Diabetology

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION