Nordihydroguaiaretic Acid Extends the Lifespan ofDrosophilaand Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice

Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice

(2014) Stephen R. Spindler et al.   AGE

Longevity, aging and rapamycin

(2014) Dan Ehninger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Minimum Size Survival Analysis Sampling Plans for Comparing Multiple Treatment Groups to a Single Control Group

(2014) Daniel R. Jeske et al.   COMMUNICATIONS IN STATISTICS-THEORY AND METHODS

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

(2013) Stephen R. Spindler et al.   AGE

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

(2013) Stephen R. Spindler et al.   AGE

Longevity effect of IGF-1R+/−mutation depends on genetic background-specific receptor activation

(2013) Jie Xu et al.   AGING CELL

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

(2013) David E. Harrison et al.   AGING CELL

Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

(2013) C. Selman et al.   Biology Letters

Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells

(2013) Angel Mauricio Castro-Gamero et al.   INVESTIGATIONAL NEW DRUGS

Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span

(2013) A. Lorenzini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Influence on Longevity of Blueberry, Cinnamon, Green and Black Tea, Pomegranate, Sesame, Curcumin, Morin, Pycnogenol, Quercetin, and Taxifolin Fed Iso-Calorically to Long-Lived, F1 Hybrid Mice

(2013) Stephen R. Spindler et al.   REJUVENATION RESEARCH

mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo

(2012) Yue Zhang et al.   BREAST CANCER RESEARCH AND TREATMENT

Novel Protein Kinase Signaling Systems Regulating Lifespan Identified by Small Molecule Library Screening Using Drosophila

(2012) Stephen R. Spindler et al.   PLoS One

Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation

(2012) Stephen R. Spindler et al.   PLoS One

Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span

(2011) Stephen Richard Spindler   AGE

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer

(2010) Charles J. Ryan et al.   BJU INTERNATIONAL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice

(2010) K. Flurkey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Vitamin/mineral supplements: of questionable benefit for the general population

(2010) Donald B McCormick   NUTRITION REVIEWS

Caloric restriction: From soup to nuts

(2009) Stephen R. Spindler   AGEING RESEARCH REVIEWS

Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria

(2009) Diksha Dani et al.   BIOGERONTOLOGY

Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid

(2009) Ross O. Meyers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Update on the oxidative stress theory of aging: Does oxidative stress play a role in aging or healthy aging?

(2009) Adam B. Salmon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Testing for differences in distribution tails to test for differences in 'maximum' lifespan

(2008) Guimin Gao et al.   BMC Medical Research Methodology

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF‐1 receptor and androgen dependent growth of LAPC‐4 prostate cancer cells

(2008) Charles J. Ryan et al.   PROSTATE

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells

(2007) Marianna Zavodovskaya et al.   JOURNAL OF CELLULAR BIOCHEMISTRY