Bacterial phosphoglycosyl transferases: initiators of glycan biosynthesis at the membrane interface

MraY–antibiotic complex reveals details of tunicamycin mode of action

(2017) Jonna K Hakulinen et al.   Nature Chemical Biology

Analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate

(2017) Debasis Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors

(2016) Katsuhiko Mitachi et al.   ANALYTICAL BIOCHEMISTRY

Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents

(2016) Daniel Wiegmann et al.   Beilstein Journal of Organic Chemistry

Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily

(2016) Bayan Al-Dabbagh et al.   BIOCHIMIE

Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays

(2016) Stephanie Wohnig et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Nucleoside Derived Antibiotics to Fight Microbial Drug Resistance: New Utilities for an Established Class of Drugs?

(2016) Michaela Serpi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stereocontrolled Total Synthesis of Muraymycin D1 Having a Dual Mode of Action against Mycobacterium tuberculosis

(2016) Katsuhiko Mitachi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

(2016) Ben C. Chung et al.   NATURE

A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes

(2016) Debasis Das et al.   Scientific Reports

A Modular Approach to the Total Synthesis of Tunicamycins

(2015) Jiakun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conservation and Covariance in Small Bacterial Phosphoglycosyltransferases Identify the Functional Catalytic Core

(2015) Vinita Lukose et al.   BIOCHEMISTRY

A comprehensive review of glycosylated bacterial natural products

(2015) Sherif I. Elshahawi et al.   CHEMICAL SOCIETY REVIEWS

A Modular Approach to Phosphoglycosyltransferase Inhibitors Inspired by Nucleoside Antibiotics

(2015) Marthe T. C. Walvoort et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antibacterial Nucleoside Natural Products Inhibiting Phospho-MurNAc-Pentapeptide Translocase; Chemistry and Structure-Activity Relationship.

(2015) S. Ichikawa et al.   CURRENT MEDICINAL CHEMISTRY

Lipid Requirements for the Enzymatic Activity of MraY Translocases andin VitroReconstitution of the Lipid II Synthesis Pathway

(2015) Erik Henrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5′-Methylene-triazole-substituted-aminoribosyl uridines as MraY inhibitors: synthesis, biological evaluation and molecular modeling

(2015) Mickaël J. Fer et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemoenzymatic syntheses of water-soluble lipid I fluorescent probes

(2015) Katsuhiko Mitachi et al.   TETRAHEDRON LETTERS

Nucleoside antibiotics: biosynthesis, regulation, and biotechnology

(2015) Guoqing Niu et al.   TRENDS IN MICROBIOLOGY

Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family

(2015) Sarah E. Furlong et al.   Scientific Reports

Lead Structures for New Antibacterials: Stereocontrolled Synthesis of a Bioactive Muraymycin Analogue

(2014) Anatol P. Spork et al.   CHEMISTRY-A EUROPEAN JOURNAL

Function-Oriented Synthesis of Liponucleoside Antibiotics

(2014) Tetsuya Tanino et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Sweet Tooth of Bacteria: Common Themes in Bacterial Glycoconjugates

(2014) H. L. P. Tytgat et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa

(2014) Yusuke Takeoka et al.   ACS Medicinal Chemistry Letters

Biosynthesis of UDP-N,N′-diacetylbacillosamine in Acinetobacter baumannii: Biochemical characterization and correlation to existing pathways

(2013) Michael J. Morrison et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibition of the First Step in Synthesis of the Mycobacterial Cell Wall Core, Catalyzed by the GlcNAc-1-phosphate Transferase WecA, by the Novel Caprazamycin Derivative CPZEN-45

(2013) Yoshimasa Ishizaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toward Analogues of MraY Natural Inhibitors: Synthesis of 5′-Triazole-Substituted-Aminoribosyl Uridines Through a Cu-Catalyzed Azide–Alkyne Cycloaddition

(2013) Mickaël J. Fer et al.   JOURNAL OF ORGANIC CHEMISTRY

Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis

(2013) Angelyn Larkin et al.   Nature Chemical Biology

Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis

(2013) B. C. Chung et al.   SCIENCE

Synthesis of pacidamycin analogues via an Ugi-multicomponent reaction

(2012) Kazuya Okamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl-phosphateN-acetylaminosugar-1-phosphate transferase

(2012) Sarah E. Furlong et al.   PROTEIN SCIENCE

At the membrane frontier: A prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates

(2011) Meredith D. Hartley et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biochemical Characterization of the O-Linked Glycosylation Pathway inNeisseria gonorrhoeaeResponsible for Biosynthesis of Protein Glycans ContainingN,N′-Diacetylbacillosamine

(2011) Meredith D. Hartley et al.   BIOCHEMISTRY

The C-terminal domain of the Salmonella enterica WbaP (UDP-galactose:Und-P galactose-1-phosphate transferase) is sufficient for catalytic activity and specificity for undecaprenyl monophosphate

(2011) K. B. Patel et al.   GLYCOBIOLOGY

Preparative Scale Cell-free Production and Quality Optimization of MraY Homologues in Different Expression Modes

(2011) Yi Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total Synthesis and Biological Evaluation of Pacidamycin D and Its 3′-Hydroxy Analogue

(2011) Kazuya Okamoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Comparative genomics analysis of completely sequenced microbial genomes reveals the ubiquity of N-linked glycosylation in prokaryotes

(2011) Manjeet Kumar et al.   Molecular BioSystems

Functional analysis of the C-terminal domain of the WbaP protein that mediates initiation of O antigen synthesis in Salmonella enterica

(2010) K. B. Patel et al.   GLYCOBIOLOGY

Analogies and homologies in lipopolysaccharide and glycoprotein biosynthesis in bacteria

(2010) I. Hug et al.   GLYCOBIOLOGY

AglJ Adds the First Sugar of the N-Linked Pentasaccharide Decorating the Haloferax volcanii S-Layer Glycoprotein

(2010) L. Kaminski et al.   JOURNAL OF BACTERIOLOGY

New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity

(2010) Amany E. Ragab et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Biological Evaluation of Muraymycin Analogues Active against Anti-Drug-Resistant Bacteria

(2010) Tetsuya Tanino et al.   ACS Medicinal Chemistry Letters

Structure and synthesis of polyisoprenoids used in N-glycosylation across the three domains of life

(2009) Meredith B. Jones et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

A general protocol for the crystallization of membrane proteins for X-ray structural investigation

(2009) Zachary E R Newby et al.   Nature Protocols

Chemoenzymatic synthesis of polyprenyl phosphates

(2008) Meredith D. Hartley et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Pacidamycin Antibiotics Through Precursor-Directed Biosynthesis

(2008) Sabine Grüschow et al.   CHEMBIOCHEM

Purification and Characterization of the Bacterial UDP-GlcNAc:Undecaprenyl-Phosphate GlcNAc-1-Phosphate Transferase WecA

(2008) B. Al-Dabbagh et al.   JOURNAL OF BACTERIOLOGY

Distinct functional domains of the Salmonella enterica WbaP transferase that is involved in the initiation reaction for synthesis of the O antigen subunit

(2008) M. S. Saldias et al.   MICROBIOLOGY-SGM