Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

Outcome after first relapse in children with acute lymphoblastic leukemia: A report based on the Dutch Childhood Oncology Group (DCOG) relapse all 98 protocol

(2011) H. van den Berg et al.   PEDIATRIC BLOOD & CANCER

Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing

(2011) Zhifu Sun et al.   PLoS One

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis

(2011) I Ahmad et al.   Cell Death & Disease

BTG1 regulates glucocorticoid receptor autoinduction in acute lymphoblastic leukemia

(2010) J. C. van Galen et al.   BLOOD

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition

(2010) P. S. Bachmann et al.   BLOOD

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting

(2010) E. Schafer et al.   BLOOD

CharacterizationCSMD1in a large set of primary lung, head and neck, breast and skin cancer tissues

(2010) Changqing Ma et al.   CANCER BIOLOGY & THERAPY

DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia

(2010) Maria E. Figueroa et al.   CANCER CELL

Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?

(2010) F. Takahashi-Yanaga et al.   CLINICAL CANCER RESEARCH

Identification ofptproas a novel target gene of Wnt signaling and its potential role as a receptor for Wnt

(2010) Minseong Kim et al.   FEBS LETTERS

Integrative analysis of the melanoma transcriptome

(2010) M. F. Berger et al.   GENOME RESEARCH

Role of Wnt canonical pathway in hematological malignancies

(2010) Xueling GE et al.   Journal of Hematology & Oncology

Genome-wide expression analysis of paired diagnosis–relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype

(2010) F J T Staal et al.   LEUKEMIA

Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation

(2010) Elizabeth A. Griffiths et al.   LEUKEMIA & LYMPHOMA

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

(2009) D. J. P. M. Stumpel et al.   BLOOD

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

(2009) L. Milani et al.   BLOOD

Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study

(2009) Miyoung Kim et al.   CANCER GENETICS AND CYTOGENETICS

MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

(2009) S. Yip et al.   CLINICAL CANCER RESEARCH

The DNA methylome of pediatric acute lymphoblastic leukemia

(2009) Josef Davidsson et al.   HUMAN MOLECULAR GENETICS

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia

(2008) Deborah French et al.   BLOOD

Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia

(2008) J. J. Yang et al.   BLOOD

Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia

(2008) M. Case et al.   CANCER RESEARCH

PTPROt Inactivates the Oncogenic Fusion Protein BCR/ABL and Suppresses Transformation of K562 Cells

(2008) Tasneem Motiwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia

(2008) S-Q Kuang et al.   LEUKEMIA

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE