Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia

A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification

(2012) Clara Bueno et al.   CELL RESEARCH

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia

(2011) R. Montes et al.   BLOOD

The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4

(2010) A. Bursen et al.   BLOOD

Long FLT3 internal tandem duplications and reduced PML-RAR  expression at diagnosis characterize a high-risk subgroup of acute promyelocytic leukemia patients

(2010) M. C. Chillon et al.   HAEMATOLOGICA

Implementation of array based whole-genome high-resolution technologies confirms the absence of secondary copy-number alterations in MLL-AF4-positive infant ALL patients

(2010) M Bardini et al.   LEUKEMIA

Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement

(2010) C Bueno et al.   LEUKEMIA

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL

(2010) Ashish R. Kumar et al.   LEUKEMIA RESEARCH

Molecular stratification model for prognosis in cytogenetically normal acute myeloid leukemia

(2009) C. M. Santamaria et al.   BLOOD

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

Etoposide induces MLL rearrangements and other chromosomal abnormalities in human embryonic stem cells

(2009) Clara Bueno et al.   CARCINOGENESIS

Multistep pathogenesis of leukemia via the MLL-AF4 chimeric gene/Flt3 gene tyrosine kinase domain (TKD) mutation-related enhancement of S100A6 expression

(2009) Hiroki Yamaguchi et al.   EXPERIMENTAL HEMATOLOGY

Bone marrow mesenchymal stem cells from infants with MLL-AF4+acute leukemia harbor and express the MLL-AF4 fusion gene

(2009) Pablo Menendez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4

(2009) M Bardini et al.   LEUKEMIA

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

(2008) M. G. Guenther et al.   GENES & DEVELOPMENT

NG2 antigen is expressed in CD34+ HPCs and plasmacytoid dendritic cell precursors: is NG2 expression in leukemia dependent on the target cell where leukemogenesis is triggered?

(2008) C Bueno et al.   LEUKEMIA

Clinical relevance ofFLT3gene abnormalities in Brazilian patients with infant leukemia

(2008) Mariana Emerenciano et al.   LEUKEMIA & LYMPHOMA