Review
Clinical Neurology
Shai David Ben-Shoshan, Sara Diana Lolansen, Tiit Illimar Mathiesen, Nanna Macaulay
Summary: This systematic review aims to explore the molecular mechanisms underlying posthemorrhagic hydrocephalus (PHH) by evaluating existing literature on increased CSF secretion and impaired CSF absorption. The results suggest that the pathological accumulation of cerebrospinal fluid in PHH may arise from a combination of increased secretion and impaired absorption, which may manifest at different time scales following a hemorrhagic event.
ACTA NEUROCHIRURGICA
(2023)
Review
Clinical Neurology
Camilla de Laurentis, Paola Cristaldi, Andrea Arighi, Clarissa Cavandoli, Andrea Trezza, Erik P. Sganzerla, Carlo G. Giussani, Andrea Di Cristofori
Summary: This systematic review explores the role of aquaporins (AQPs) in the pathophysiology of hydrocephalus, finding a general increase of AQPs in hydrocephalic patients but a tendency towards reduction in patients with idiopathic normal pressure hydrocephalus, suggesting AQPs may serve as diagnostic tools or therapeutic targets for hydrocephalus management.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Diana Lolansen, Nina Rostgaard, Tenna Capion, Nicolas H. Norager, Markus Harboe Olsen, Marianne Juhler, Tiit Illimar Mathiesen, Nanna MacAulay
Summary: The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain unclear, but elevated cerebrospinal fluid (CSF) osmolality is not the cause of PHH. The pathological CSF accumulation observed in these patients is instead attributed to other pathological alterations associated with the abnormal presence of blood within the CSF compartments following subarachnoid hemorrhage (SAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Timothy Wong, Justin Gold, Ryan Houser, Yehuda Herschman, Raja Jani, Ira Goldstein
Summary: Cerebrospinal fluid (CSF) diversion is a common neurosurgical procedure, with ventriculoperitoneal (VP) shunting being a widely used technique. In addition to VP shunting, ventriculopleural (VPL) shunting is also used in some patients, but can lead to complications such as pleural effusion and pneumothorax.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Leroy ten Dam, Diederik van de Beek, Matthijs C. Brouwer
Summary: In patients with neurosarcoidosis and hydrocephalus, female patients are more common with clinical symptoms such as headache and vertigo. Treatment involves glucocorticoids and neurosurgical intervention, with generally favorable outcomes.
JOURNAL OF NEUROLOGY
(2022)
Article
Cell Biology
Alexandra Gerasimov, Valery Golderman, Shany Guly Gofrit, Shay Anat Aharoni, Daniela Noa Zohar, Ze'ev Itsekson-Hayosh, Tsviya Fay-Karmon, Sharon Hassin-Baer, Joab Chapman, Nicola Maggio, Efrat Shavit-Stein
Summary: In this study, a specific and sensitive enzymatic assay was developed to measure thrombin and aPC activity in the cerebrospinal fluid (CSF). The activities of thrombin and aPC were found to be significantly higher in patients with central nervous system infections compared to normal pressure hydrocephalus controls, suggesting their involvement in neuro-inflammation. This method may be useful for assessing the degenerative and protective effects of coagulation on neurological disorders.
NEURAL REGENERATION RESEARCH
(2021)
Review
Neurosciences
Yijian Yang, Chuansen Wang, Rui Chen, Yuchang Wang, Changwu Tan, Jingping Liu, Qinghua Zhang, Gelei Xiao
Summary: In this review, we summarize the astrocyte reactivity induced by hydrocephalus and their corresponding functions. We also discuss the therapeutic effects of regulating astrocytes in hydrocephalus.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Immunology
Joanna Kaminska, Mateusz Maciejczyk, Agnieszka Cwiklinska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Summary: This study evaluated the concentration of pro-inflammatory and anti-inflammatory cytokines in CSF and serum of UIA patients, finding that in CSF, most proteins showed significantly higher concentration in UIA patients compared to the control group, while no significant difference was observed in serum. Furthermore, some inflammatory factors were positively or negatively correlated with the size and number of aneurysms.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Infectious Diseases
Antonia Diederichs, Evelyn Pawlik, Anke Barnbrock, Stefan Schoening, Juergen Konczalla, Tobias Finger, Thomas Lehrnbecher, Stephan Goettig, Konrad Bochennek
Summary: Infection of the cerebrospinal fluid system is a serious medical complication. The incidence of infection did not significantly differ between children with and without cancer, but was highest in children younger than one year. Infection occurred earlier in external ventricular drain (EVD) than ventriculoperitoneal (VP) shunt, and in children with cancer compared with patients without cancer. The isolated pathogens were mainly Gram-positive bacteria, particularly Staphylococcus spp.
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to investigate the potential of AQP1 and AQP4 proteins in CSF as biomarkers for iNPH, but ELISA analysis showed insufficient sensitivity to detect their presence. The study also revealed differences in vascular risk factors between patients with iNPH and AD.
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to analyze the presence of AQP1 and AQP4 in the CSF of iNPH and AD patients as potential biomarkers. However, ELISA analysis showed insufficient sensitivity to detect these proteins, ruling out their use as biomarkers for diagnosing iNPH.
Article
Biochemistry & Molecular Biology
Trine L. Toft-Bertelsen, Soren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Marianne Juhler, Nanna Macaulay
Summary: The lipidomic signature of CSF in patients with subarachnoid hemorrhage suggests dysregulation of lipids and potential biomarkers for future treatment options.
Article
Biochemistry & Molecular Biology
Jose Luis Trillo-Contreras, Juan Jose Toledo-Aral, Javier Villadiego, Miriam Echevarria
Summary: Aquaporin-4 (AQP4) is the principal water channel in the brain, playing a crucial role in cerebrospinal fluid (CSF) homeostasis and hydrocephalus. The study found that alterations associated with hydrocephalic state may not be permanent, as some symptoms can be reversed by reexposure to normoxia, but deficits in CSF outflow and ventricular distensibility persist.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kornelia Laichinger, Paula Bombach, Jutta Duenschede, Christoph Ruschil, Maria-Ioanna Stefanou, Evelyn Dubois, Sven Poli, Katharina Feil, Ulf Ziemann, Markus Kowarik, Annerose Mengel
Summary: In this study, the prevalence of intrathecal IgG synthesis and B cell activation in AIS patients was determined. It was found that 5.7% of patients had intrathecal IgG synthesis, and one third of these patients had concurrent chronic inflammatory CNS disease. No significant correlation was found with stroke characteristics.
Review
Immunology
Yijian Yang, Jian He, Yuchang Wang, Chuansen Wang, Changwu Tan, Junbo Liao, Lei Tong, Gelei Xiao
Summary: The choroid plexus, consisting mainly of choroid plexus epithelium cells, is located in the lateral ventricles of the brain. Its main function is thought to be the secretion and regulation of cerebrospinal fluid, with additional functions such as assisting in waste removal, participating in apoptosis, and aiding in brain repair and immune response. Abnormalities in choroid plexus epithelium cells, along with inflammation and changes in cilia, may lead to abnormal conditions in cerebrospinal fluid and the development of hydrocephalus. This review discusses the pathophysiological mechanism of hydrocephalus and explores the potential use of choroid plexus epithelium cells as a therapeutic target.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Henryk Jesko, Przemyslaw L. Wencel, Walter J. Lukiw, Robert P. Strosznajder
MOLECULAR NEUROBIOLOGY
(2019)
Review
Neurosciences
Henryk Jesko, Adam Stepien, Walter J. Lukiw, Robert P. Strosznajder
MOLECULAR NEUROBIOLOGY
(2019)
Review
Neurosciences
Kinga Czubowicz, Henryk Jesko, Przemyslaw Wencel, Walter J. Lukiw, Robert P. Strosznajder
MOLECULAR NEUROBIOLOGY
(2019)
Article
Immunology
Ewelina Kiernozek, Anna Bienkowska, Magdalena Markowska, Ewa Kozlowska, Nadzieja Drela
Letter
Immunology
Julian Swatler, Wioleta Dudka, Lukasz Bugajski, Marta Brewinska-Olchowik, Ewa Kozlowska, Katarzyna Piwocka
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Michal Janyst, Beata Kaleta, Karolina Janyst, Radoslaw Zagozdzon, Ewa Kozlowska, Witold Lasek
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2020)
Article
Medicine, Research & Experimental
Tomasz Skirecki, Patrycja Swacha, Grazyna Hoser, Jakub Golab, Dominika Nowis, Ewa Kozlowska
Review
Oncology
Julian Swatler, Laura Turos-Korgul, Ewa Kozlowska, Katarzyna Piwocka
Summary: Effector immune system cells have the ability to kill tumor cells, but they are inhibited and evaded as myeloid leukemias develop. Factors such as inhibitory receptors, enzymes and suppressive immune cells contribute to the immunosuppressive microenvironment. Changes in immunosuppressive features during therapy include modulation of cytotoxic cells, promotion of regulatory T cells and suppressive myeloid cells, and spreading of leukemic blasts. Treatment modalities such as tyrosine kinase inhibitors and chemotherapy aim to restore effector immunity in myeloid leukemias.
Article
Hematology
Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara De Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza, Katarzyna Piwocka
Summary: Leukemic extracellular vesicles play a role in stimulating immunosuppressive Tregs and promoting leukemia growth. The study identifies Rab27a-dependent secretion of leukemic EVs as a potential therapeutic target in myeloid neoplasms.
Article
Microbiology
Jagoda Placzkiewicz, Monika Adamczyk-Poplawska, Ewa Kozlowska, Agnieszka Kwiatek
Summary: Bacteria belonging to the Neisseria genus, including both pathogenic Neisseria gonorrhoeae and commensal Neisseria sicca, can induce the secretion of proinflammatory cytokines and chemokines by infected epithelial cells. However, the effect is greater for N. gonorrhoeae compared to N. sicca. Additionally, N. gonorrhoeae and N. sicca have distinct effects on the expression of genes encoding protein components of transcription factors. N. gonorrhoeae infection leads to significant overexpression of long non-coding RNAs, while this effect is not observed for N. sicca.
Article
Geriatrics & Gerontology
Agata Gluchowska, Dominik Cysewski, Monika Baj-Krzyworzeka, Rafal Szatanek, Kazimierz Weglarczyk, Paulina Podszywalow-Bartnicka, Piotr Sunderland, Ewa Kozlowska, Malgorzata A. Sliwinska, Michal Dabrowski, Ewa Sikora, Grazyna Mosieniak
Summary: Atherosclerosis is a common age-related disease characterized by intense immunological activity. Senescent vascular smooth muscle cells (VSMCs) secrete increased number of extracellular vesicles (senEVs) that modulate the cytokine milieu by influencing immune cell activity.
Article
Food Science & Technology
Ewelina Kiernozek, Piotr Maslak, Ewa Kozlowska, Ingeborga Jarzyna, Dominika Srednicka-Tober, Ewelina Hallmann, Renata Kazimierczak, Nadzieja Drela, Ewa Rembialkowska
Summary: Researchers compared blueberry fruit extracts from different cultivation systems and found that biodynamic cultivation had the strongest inhibitory activity against cell proliferation, while organic cultivation had the highest levels of induced apoptosis. However, the blueberry extracts did not affect the therapeutic efficacy of anticancer drugs, and the activity of blueberry fruit extracts varied in consecutive years of cultivation.
Letter
Hematology
Julian Swatler, Domenico Lo Tartaro, Rebecca Borella, Marta Brewinska-Olchowik, Annamaria Paolini, Anita Neroni, Laura Turos-Korgul, Milena Wiech, Ewa Kozlowska, Dominik Cysewski, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Rafael J. Argueello, Andrea Cossarizza, Sara De Biasi, Katarzyna Piwocka
Meeting Abstract
Biochemistry & Molecular Biology
A. Ciolko, L. Bugajski, P. Sunderland, M. Sliwinska, E. Kozlowska, E. Sikora, G. Mosieniak
Meeting Abstract
Critical Care Medicine
Tomasz Skirecki, Patrycja Swacha, Grazyna Hoser, Ewa Kozlowska
