Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection

Hyperactivation of mammalian target of rapamycin complex 1 by HIV-1 is necessary for virion production and latent viral reactivation

(2017) Binod Kumar et al.   FASEB JOURNAL

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

(2017) Alyssa R. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses

(2017) Nikolaos Patsoukis et al.   Frontiers in Immunology

Immunometabolic and Lipidomic Markers Associated With the Frailty Index and Quality of Life in Aging HIV+ Men on Antiretroviral Therapy

(2017) Hui-Ling Yeoh et al.   EBioMedicine

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure

(2016) Clovis S. Palmer et al.   JOURNAL OF IMMUNOLOGY

Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis

(2016) Clovis S. Palmer et al.   EBioMedicine

Regulators of Glucose Metabolism in CD4+ and CD8+ T Cells

(2015) Clovis S. Palmer et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

(2015) Alonso Heredia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

(2015) Clovis S. Palmer et al.   Frontiers in Immunology

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells

(2014) Andrea Hegedus et al.   Retrovirology

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

(2013) Clovis S. Palmer et al.   AIDS

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

(2013) David G. Winkler et al.   CHEMISTRY & BIOLOGY

PI3Kγ kinase activity is required for optimal T-cell activation and differentiation

(2013) Nadia Ladygina et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

The Novel Therapeutic Effect of Phosphoinositide 3-Kinase-  Inhibitor AS605240 in Autoimmune Diabetes

(2012) J. Azzi et al.   DIABETES

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

(2012) D. C. Henstridge et al.   DIABETOLOGIA

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glut1-mediated glucose transport regulates HIV infection

(2012) S. Loisel-Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases

(2012) David K. Finlay   Frontiers in Immunology

mTOR as a multifunctional therapeutic target in HIV infection

(2011) Ferdinando Nicoletti et al.   DRUG DISCOVERY TODAY

OX40 Complexes with Phosphoinositide 3-Kinase and Protein Kinase B (PKB) To Augment TCR-Dependent PKB Signaling

(2011) T. So et al.   JOURNAL OF IMMUNOLOGY

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

(2011) N. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection

(2011) Yongjun Yu et al.   TRENDS IN MICROBIOLOGY

Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC–MS/MS analysis

(2011) Joseph A. Hollenbaugh et al.   VIROLOGY

Metabolism in T cell activation and differentiation

(2010) Erika L Pearce   CURRENT OPINION IN IMMUNOLOGY

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Glutamine Metabolism Is Essential for Human Cytomegalovirus Infection

(2009) J. W. Chambers et al.   JOURNAL OF VIROLOGY

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A novel role for adiponectin in regulating the immune responses in chronic hepatitis C virus infection

(2008) Clovis Palmer et al.   HEPATOLOGY

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

(2008) Nancie J. MacIver et al.   JOURNAL OF LEUKOCYTE BIOLOGY